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A study conducted in France analyzed 1533 cases of drug overdose and drug abuse between 2010 and 2021. The study found that 12 patients died as a result of cardiorespiratory arrest or drug toxicity following suicide attempts or drug abuse involving fentanyl, sufentanil, or ocfentanil. Seven of the patients also died after receiving treatment with other drugs such as oxycodone, methadone, clomipramine, tramadol, or alcohol. Autopsies confirmed that all patients had toxic levels of fentanyl, sufentanil, or ocfentanil in their systems. The study highlights the dangers of drug abuse and overdose, particularly with these specific substances. [Extracted from the article]

A retrospective study described 11 patients, aged 9-74 years, who developed DRESS syndrome while being treated with various drugs including allopurinol, carbamazepine, leflunomide, sodium-valproate, and sulfasalazine. The patients experienced symptoms of DRESS syndrome 2-8 weeks after starting treatment. Laboratory tests showed abnormal leukocyte counts, eosinophil counts, AST, and ALT levels. Treatment with prednisolone or ciclosporin resulted in improvement, but unfortunately, two patients later died from sepsis-nosocomial infection or myocardial infarction and heart failure. [Extracted from the article]

A secondary analysis of the SENATOR trial, conducted in six large teaching hospitals in Europe, found that adverse drug reactions (ADRs) are more common in women than in men in older people in an acute hospital setting. This is due to potentially inappropriate medications (PIMs) or potential prescribing omissions (PPOs). The study included 1537 patients with at least three chronic medical conditions and polypharmacy. The prevalence of certain PIMs and PPOs was higher in female patients, while some ADRs were reported more frequently in women. The authors concluded that ADRs were detected more frequently in older women, along with certain PIMs and PPOs. [Extracted from the article]

A study of 38 patients conducted from January 2020 to December 2021 found that some patients, aged 1.1-19.6 years, developed urinary tract infections, acute kidney injury, or experienced a lack of efficacy while being treated for heart failure with various medications including dapagliflozin, digoxin, ivabradine, milrinone, sacubitril/valsartan, hydralazine/isosorbide dinitrate, mineralocorticoid-receptor-antagonists, diuretics, and beta-adrenergic-receptor-antagonists. Some patients also exhibited a lack of efficacy with these medications, leading to worsening of their heart condition. One patient died due to cardiac arrest, indicating a lack of efficacy. Urinary tract infection patients received unspecified antibiotics, and one patient discontinued dapagliflozin. [Extracted from the article]

This article discusses a retrospective review study of eight patients who developed aspirin-exacerbated respiratory disease or gastrointestinal adverse effects while being treated with aspirin. These patients also experienced lack of efficacy when treated with mepolizumab or unspecified corticosteroids for their respiratory disease. The article provides individual case summaries for each patient, detailing their treatment history and outcomes. Overall, the study suggests that mepolizumab may not be effective in treating aspirin-exacerbated respiratory disease in these patients. [Extracted from the article]

A retrospective study of 36 patients with urothelial carcinoma (UC) found that one patient experienced lack of efficacy during treatment with enfortumab vedotin and pembrolizumab, while another patient developed hypoesthesia during treatment with disitamab-vedotin. The female patient showed a partial response to disitamab-vedotin but developed grade 2 hypoesthesia, leading to the discontinuation of the treatment. The male patient initially received cisplatin and gemcitabine with symptom improvement, but experienced disease progression when treated with enfortumab-vedotin and pembrolizumab. He then received disitamab-vedotin and had a partial response. [Extracted from the article]

The Medicines and Healthcare products Regulatory Agency (MHRA) in the UK has introduced new safety and educational materials for patients and healthcare professionals regarding the use of valproate. These materials aim to reduce the risks associated with valproate use, such as congenital abnormalities during pregnancy and impaired fertility in males. Healthcare professionals are advised not to initiate valproate treatment in new male or female patients under 55 years of age unless there are no other effective or tolerated treatments. The Commission on Human Medicines is also considering data suggesting an increased risk of neurodevelopmental disorders in children whose fathers took valproate before conception. The new materials include updated guides for healthcare professionals and patients, an annual risk acknowledgement form, a patient card on contraception and pregnancy prevention, a pharmacy poster, and warning stickers for packaging. [Extracted from the article]

A retrospective study of 400 patients conducted between 2010 and 2019 found that six patients, aged 9 months to 5 years, developed various complications after receiving the BCG vaccine. These complications included skin lesions, skin ulcers, osteomyelitis, and Mycobacterium bovis generalized infection. The cases described in the study involved both male and female patients. Treatment with a combination of isoniazid, rifampicin, ethambutol, and moxifloxacin was administered to the patients, and most of them showed clinical improvement. However, one patient with underlying immunodeficiency died from multiorgan failure. [Extracted from the article]

In April 2023, the UK Medicines and Healthcare products Regulatory Agency (MHRA) introduced new safety measures aimed at strengthening the safety of isotretinoin treatment with regard to risks of psychiatric disorders and sexual dysfunction. Isotretinoin treatment for acne is associated with risks of psychiatric disorders and sexual dysfunction, advises the Malaysian National Pharmaceutical Regulatory Agency (NPRA). [Extracted from the article]

This report describes the 17-year-old female to male transgender patient (patient no. 4 from table 1 of the article): The patient underwent nipple-sparing mastectomy and received treatment with testosterone cipionate for 33 months. This report describes the 18-year-old female to male transgender patient (patient no. 14 from table 1 of the article): The patient underwent nipple-sparing mastectomy and received treatment with testosterone cipionate for 34 months. This report describes the 16-year-old female to male transgender patient (patient no. 3 from table 1 of the article): The patient underwent nipple-sparing mastectomy and received treatment with testosterone cipionate for 18 months. This report describes the 18-year-old female to male transgender patient (patient no. 12 from table 1 of the article): The patient underwent nipple-sparing mastectomy and received treatment with testosterone cipionate for 27 months. [Extracted from the article]

B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event In a single-centre retrospective study performed between January 2018 to May 2021 involving 486 brain dead liver donors; 9 donors (5 female patients and 4 male patients), aged 9-61 years were described, who exhibited lack of efficacy following administration of heparin to prevent donor hepatic artery thrombosis (dHAT) [ I routes not stated i ]. Case 5: A 44-year-old ischaemic stroke associated brain dead man was identified as a liver donor. Case 6: A 44-year-old ischaemic stroke associated brain dead man was identified as a liver donor. [Extracted from the article]

Presents information on several research regarding adverse drug reaction as of August 28, 2004. Incidence and characteristics of neurological complications associated with alemtuzumab-based reduced-intensity stem cell transplantation; Impact of tamoxifen on the adverse effects of antineoplastic therapy on serum lipid levels in premenopausal patients; Quality of life effect of antipsychotic therapy in patients who did or did not develop metabolic disturbances; Discontinuation rate of leflunomide in outpatients with rheumatoid arthritis receiving usual care.

Describes several case reports on the side effects of various drugs. Occurrence of uveities following ophthalmic administration of bimatropost in an elderly patient; Details of a case of a possible interaction between itraconazole and inhaled budesonide resulted in Cushing's syndrome in a 70-year old woman; Occurrence of aseptic meningitis in a 65-year old woman during treatment with celecoxib for osetoarthritis.

This section offers news briefs on adverse reaction research as of January 2010. A study revealed that peginterferon-α + ribavirin-induced bacterial infections are not related to neutropenia. Another research showed an increased risk of valproic acid-induced hepatotoxicity in genetic variation in mitochondrial DNA polymerase-ϒ. A study suggested that the combined ribavirin and interferon therapy may increase the risk of severe depression in patients with chronic hepatitis C.

Presents news briefs on public health as of August 28, 2004. Clinically important differences between levothyroxine products, according to the American Thyroid Association and the American Association of Clinical Endocrinologists. Association of leflunomide with an elevated incidence of peripheral neuropathy in patients with rheumatoid arthritis; Occurrence and characteristics of fat redistribution and dyslipidaemia associated with protease inhibitor use in children with HIV infection; Effectiveness of fluvastatin and pravastatin and their possible interactions with indinavir in HIV infected patients.

Presents information on several research regarding adverse drug reaction and public health as of July 10, 2004. Effect of didanosine in combination with tenofovir disoproxil fumarate on patients with HIV infection; Impact of folate therapy on patients after coronary stenting; Association of hormone replacement therapy with dementia; Cardiovascular effects of frovatriptan during a migraine attack.

Discusses several research on adverse drug reactions (ADR). Link between the use of antipsychotics and hyperlipidaemia; Side effects of abciximac on patients undergoing coronary stenting; Evaluation of the effect of ADR on hospital costs.

The article presents a retrospective study of patients who were treated with immunosuppressants for various diseases and eventually developed various toxicities and opportunistic infections. According to the author, strong use of immunosuppressants like etanercept, fludarabine and prednisolone can lead to opportunistic infections or patient death.

The article looks at the retrospective studies of patients diagnosed with cytomegalovirus infection in their upper gastrointestinal tract. Topics include the patients' treatment with mycophenolic acid and corticosteroid, patients with Epstein Barr virus infection and acute myeloid leukemia, and immunosuppressive treatments' impact on patients leading to cytomegalovirus viremia.

There several reasons for prescribing errors which place paediatric patients at risk of harm, according to findings of a scoping review published in I BMJ Open i . The results data were charted, collated and reported, and then presented to six prescribing stakeholders for consultation to establish the validity, relevance and mechanism of prescribing errors. [Extracted from the article]

The article presents a case study of three male patients between 20-34 years of age developing dependency on tapentadol due to depressive symptoms.

The article presents a case study of 13 patients undergoing treatment with palbociclib for metastatic breast cancer, developing febrile neutropenia and receiving treatment with oral palbociclib.

The article presents a case study of 134 patients developing sterile endophthalmitis during the treatment with intravitreal triamcinolone injection for diabetic retinopathy.

The article presents a case study of a 78 year-old man who has developed Kluyvera ascorbata biliary tract infection following chemotherapy with cisplatin and gemcitabine for cholangiocarcinoma.

The article presents a case study of a patient with Hodgkin's lymphoma who developed hyperglycaemia after treatment with multiple drugs, including bleomycin, etoposide, and doxorubic.

The article presents a case study of a 59-year-old man with osteomyelitis who developed reversible cerebellar neurotoxicity during metronidazole treatment.

The article presents case studies of patients with giant cell arteritis in which the first woman patient developed cataract while the other developed osteoporosis and diabetes mellitus during treatment with methylprednisolone.