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This document provides a list of drugs associated with non-serious adverse events identified in the scientific literature over the last week. The table includes the drug names, the adverse events reported, and the number of cases. Some of the adverse events mentioned include joint disorders, abdominal pain, alopecia, dizziness, fatigue, nausea, and skin disorders. It is important to note that this information is based on case reports and should be interpreted with caution. [Extracted from the article]

This document provides a list of drugs associated with non-serious adverse events identified in the scientific literature over the last week. The table includes the drug names, the adverse events reported, and the number of cases. Some of the adverse events mentioned include joint disorders, abdominal pain, alopecia, dizziness, fatigue, nausea, and skin disorders. It is important to note that this information is based on case reports and should be interpreted with caution. [Extracted from the article]

This article presents three case reports of drug intoxication and overdose in suicide attempts among adolescents. The first case involves a 17-year-old boy who intentionally took multiple medications prescribed to his parents, resulting in intoxication and eventual death. The second case involves a 14-year-old girl who overdosed on amlodipine, prescribed to her father, leading to multiorgan failure and death. The third case involves a 17-year-old girl who took doxepin, prescribed to her parents, resulting in intoxication and death. Autopsy findings confirmed the presence of the respective drugs in each case. [Extracted from the article]

A single-center retrospective cross-sectional study was conducted to examine cases of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) in 23 patients between January 2014 and September 2020. The study found that patients developed DRESS while being treated with various drugs, including amlodipine, carbamazepine, ciprofloxacin, diosmin/hesperidin, hydroxychloroquine, and lamotrigine. The study identified the causative drugs for DRESS in each case, with lamotrigine and carbamazepine being implicated in one case, hydroxychloroquine in another, ciprofloxacin in another, amlodipine in another, and diosmin/hesperidin in another. The study did not provide specific details about the patients' ages, sexes, treatment durations, or outcomes. [Extracted from the article]

This article describes four cases of patients, aged between 12-17 years, who experienced serious complications following an overdose of amlodipine or verapamil. Patient 1 and Patient 3 developed refractory vasodilatory shock after ingesting a large amount of amlodipine, while Patient 2 experienced refractory vasodilatory shock, junctional rhythm, and complete heart block after overdosing on verapamil. Patient 4 also developed refractory vasodilatory shock after ingesting amlodipine, along with symptoms such as nausea, vomiting, and abdominal pain. In all cases, the patients required intubation, mechanical ventilation, and central extracorporeal membrane oxygenation (ECMO) to stabilize their conditions. However, with the use of ECMO, all patients eventually recovered without any long-term complications. [Extracted from the article]

A 73-year-old woman experienced drug toxicity in the form of bradycardia and hypotension after accidentally overdosing on amlodipine. She had a weight of 69.9kg and had dementia and breast cancer. In addition to the amlodipine overdose, she also accidentally ingested a week's worth of other medications. Upon admission, she had a heart rate of 60 bpm and blood pressure of 105/39mm Hg, which decreased further due to the amlodipine overdose. The woman was treated with various medications and her condition stabilized. [Extracted from the article]

A 28-year-old man experienced severe toxic effects after intentionally overdosing on amlodipine, a medication prescribed to his mother. He presented to the emergency room with altered mental status, hypotension, hypothermia, and shock. Despite receiving fluids and vasopressors, his condition worsened, leading to vasoplegia and multi-organ dysfunction. He was treated with insulin and placed on venoarterial extracorporeal membrane oxygenation (ECMO). Eventually, his symptoms improved, and he was discharged home. The toxic effects were attributed to the intentional overdose of amlodipine. [Extracted from the article]

A case report published in Reactions Weekly describes the toxicities experienced by a 64-year-old man who intentionally overdosed on amlodipine/atenolol, a medication used to treat essential hypertension. The man had been taking the medication as prescribed but began taking higher doses due to concerns about his blood pressure. He developed extreme fatigue, pulmonary edema, hypotension, sinus bradycardia, metabolic acidosis, acute kidney injury, agitation, myocardial contractility impairment, and shock. He was treated with various medications and interventions, and ultimately recovered. The report concludes that the symptoms were a result of the overdose and misuse of amlodipine/atenolol. [Extracted from the article]

A 56-year-old man experienced angioedema while being treated with amlodipine for Raynaud's phenomenon and diltiazem for atrial flutter. The patient presented with tongue swelling and respiratory distress, and attempts to intubate him were unsuccessful due to the rigidity of his tongue. It was determined that the angioedema was caused by the recent use of amlodipine and compounded by diltiazem. The patient's condition improved after the medications were withheld and he was started on tranexamic acid, steroids, and antihistamines. [Extracted from the article]

A case study published in Reactions Weekly describes a man who experienced hypotension, bradycardia, and a fall in oxygen saturation as a result of an overdose of the medication amlodipine. The man presented with symptoms such as nausea, vomiting, and chest discomfort after taking 450mg of amlodipine. He was treated with inotropes, IV calcium, fluids, and oxygen supplementation, and underwent therapeutic plasma exchange. After two sessions of TPE, the man showed significant improvement and was discharged from the hospital within 10 days. [Extracted from the article]

A 17-year-old girl experienced shock after intentionally overdosing on amlodipine and misusing the drug. She also showed a lack of response to glucose treatment for hypoglycemia. The girl was admitted to the hospital and received various treatments, including epinephrine, norepinephrine, vasopressin, high-dose insulin therapy, methylthioninium-chloride, glucagon, and lipids. She required extracorporeal membrane oxygenation (ECMO) for hemodynamic support and experienced fluid overload, requiring additional interventions. After 2 months of hospitalization, her condition improved and she was discharged. [Extracted from the article]

The provided document is a list of drugs associated with non-serious adverse events found in scientific literature over the past week. The list includes the drug names, the adverse events, and the number of cases reported for each drug. Some examples of adverse events mentioned in the list include rosacea associated with Adalimumab, exanthema associated with Aprepitant, and periorbital edema associated with Belumosudil. This information can be useful for library patrons conducting research on specific drugs and their potential side effects. [Extracted from the article]

A 74-year-old woman experienced altered mental status, hypotension, hyperglycemia, and vasoplegic shock after overdosing on amlodipine for high blood pressure. She presented with symptoms of altered mental status and hypotension after taking an extra dose of amlodipine. She received various treatments, including calcium gluconate, glucagon, and multiple vasopressors. Her condition gradually improved over the course of several days and she was eventually discharged from the hospital. Her amlodipine levels were found to be significantly elevated during her hospital stay. [Extracted from the article]

A 74-year-old woman experienced altered mental status, hypotension, hyperglycemia, and vasoplegic shock after overdosing on amlodipine for high blood pressure. She presented with symptoms of altered mental status and hypotension after taking an extra dose of amlodipine. She received various treatments, including calcium gluconate, glucagon, and multiple vasopressors. Her condition gradually improved over the course of several days, and she was eventually discharged from the hospital. Her amlodipine levels were significantly elevated during her hospital stay. [Extracted from the article]

A descriptive retrospective study was conducted on 27 patients who developed epidermal necrolysis while receiving antibiotic therapy with azithromycin, benzathine-benzylpenicillin, or ciprofloxacin, hypertension treatment with amlodipine, or analgesic therapy with paracetamol. The patients were admitted to the hospital and their treatment with these drugs was discontinued. The study did not provide information on the patients' ages, sexes, dosages, routes, durations of treatments, or outcomes. [Extracted from the article]

A 74-year-old man intentionally overdosed on amlodipine, resulting in hypotension and hyperglycemia. The man had a history of hypertension and stroke and had taken 400mg of amlodipine in an act of self-harm. He was diagnosed with calcium channel blocker toxicity and admitted to the ICU. Treatment included continuous insulin infusion, calcium infusion, and vasopressors. His symptoms resolved after high dose insulin therapy. [Extracted from the article]

A descriptive retrospective study involving 27 patients was conducted to investigate cases of epidermal necrolysis during antibiotic and analgesic therapy. The patients were receiving various medications, including azithromycin, benzathine-benzylpenicillin, ciprofloxacin, amlodipine, and paracetamol. However, all of them developed epidermal necrolysis as a result of these medications and were subsequently admitted to the hospital. As a result, their treatment with these drugs was discontinued. [Extracted from the article]

A 74-year-old man intentionally overdosed on amlodipine, resulting in hypotension and hyperglycemia. The man had a history of hypertension and stroke and had taken 400mg of amlodipine in an act of self-harm. He was diagnosed with calcium channel blocker toxicity and admitted to the ICU. Treatment included continuous insulin infusion, calcium infusion, and vasopressors. His symptoms resolved after high dose insulin therapy. [Extracted from the article]

A 46-year-old man experienced drug-induced diffuse myocarditis after intentionally overdosing on amlodipine. He presented to the emergency department with mild abdominal pain and was discharged the next day. However, he returned two days later with worsening dyspnea and was diagnosed with myocarditis based on symptoms and investigative findings. He was treated with furosemide and showed improvement in left ventricular function upon discharge. Three months later, a follow-up cardiac MRI showed significant improvement in myocardial inflammation. [Extracted from the article]

A 59-year-old woman with a history of hypertension and hypokalaemia was treated with amlodipine and losartan but exhibited a lack of efficacy. Despite receiving these medications, her hypertension and hypokalaemia remained uncontrolled. Further examinations revealed that she had primary hyperaldosteronism due to idiopathic hyperplasia. She was then started on spironolactone, which resulted in an improvement in her condition. [Extracted from the article]

An 11-year-old boy with type 1 diabetes mellitus exhibited lack of efficacy during treatment with lisinopril and amlodipine for hypertension. The boy had issues with compliance to insulin and post-hospital follow-up. Despite receiving lisinopril and amlodipine, his hypertension was difficult to control, leading to his admission to the hospital where he was diagnosed with Cushing's disease from a functional pituitary macroadenoma. [Extracted from the article]

A 25-year-old man with a history of cystic fibrosis and a double lung transplant experienced a lack of efficacy while being treated with amlodipine, doxazosin, and telmisartan for hypertension. He presented to the emergency department with symptoms of nausea, vomiting, and abdominal pain and was diagnosed with distal intestinal obstruction syndrome. Further imaging revealed a right adrenal lesion, and he was ultimately diagnosed with pheochromocytoma. After undergoing a right adrenalectomy, his blood pressure normalized and he was discharged home. This case highlights the lack of effectiveness of the medications in controlling the patient's hypertension. [Extracted from the article]

A 74-year-old man developed BRASH syndrome while being treated for hypertension with spironolactone, amlodipine/benazepril, and metoprolol. The man presented with symptoms of fatigue, diarrhea, and lower extremity myalgias. Lab tests revealed elevated potassium levels and decreased bicarbonate levels. The diagnosis of BRASH syndrome was made based on the presenting symptoms and investigative findings. The man's medications were discontinued, and his hyperkalemia was treated. Over the next four days, his condition improved with stable heart rate and normalized kidney and potassium levels. [Extracted from the article]

A 42-year-old woman developed buccal lichenoid lesions while taking amlodipine for hypertension. She experienced progressively worsening whitish streaks and painful ulcers in her mouth. Initially diagnosed with oral lichen planus, she was treated with antibiotics and corticosteroids. However, her lesions were later determined to be a result of amlodipine therapy, and the medication was discontinued. After switching to perindopril, her symptoms improved and the lesions began to resolve. It was discovered that the woman had not been taking the perindopril due to concerns about potential side effects, indicating intentional non-compliance with treatment. [Extracted from the article]

A 74-year-old man with a history of diabetes, hypertension, atrial fibrillation, and chronic kidney disease died from BRASH syndrome after overdosing on amlodipine/valsartan/hydrochlorothiazide, a medication used to treat hypertension. He presented to the emergency department with difficulty breathing and decreased urine output. Despite receiving various treatments, including cardiac pacing and angioplasty, the patient remained in shock and bradycardia and ultimately passed away. The overdose was confirmed through drug concentration analysis, which showed high levels of amlodipine and valsartan in the patient's blood. [Extracted from the article]

A 71-year-old woman experienced a lack of efficacy while being treated with amlodipine and hydralazine for high blood pressure. The woman had a history of coronary artery bypass grafting and myxedema. She presented to the emergency department with a syncopal episode and was admitted. Despite receiving various treatments, including dopamine, her blood pressure continued to increase, indicating a lack of efficacy of hydralazine and amlodipine. She was eventually discharged on a different medication regimen. [Extracted from the article]

This article from Reactions Weekly describes three cases of refractory shock following overdose of calcium channel blockers, specifically diltiazem and amlodipine. The first case involved a 51-year-old woman who was treated with high dose vasopressors and inotropic support, but unfortunately passed away. The second case involved a 65-year-old woman who also received similar treatment but was discharged from the hospital. The third case involved an 88-year-old woman who was successfully treated and discharged from the hospital. These cases highlight the potential complications and treatment options for calcium channel blocker overdose. [Extracted from the article]

A 20-year-old female experienced cardiotoxicity after overdosing on amlodipine, a medication used to treat high blood pressure. The woman was admitted to the hospital after consuming 58 tablets of amlodipine, totaling 290mg. She developed low blood pressure and heart failure, and was treated in the intensive care unit with mechanical ventilation and various medications. The patient was ultimately successfully managed and discharged from the hospital. [Extracted from the article]

Two case studies were presented involving women who developed ankle swelling and proteinuria while being treated with amlodipine or cabozantinib for metastatic follicular carcinoma with cauda equina syndrome. In the first case, an 80-year-old woman experienced ankle swelling, tiredness, and poor appetite while taking amlodipine. The ankle swelling was attributed to amlodipine, and discontinuation of the medication was recommended. In the second case, a 71-year-old woman developed proteinuria due to cabozantinib, and discontinuation of the medication was also suggested. Regular monitoring of urine for proteinuria levels and the use of an angiotensin converting enzyme inhibitor were advised. [Extracted from the article]

An 82-year-old man developed food-dependent exercise-induced anaphylaxis while taking amlodipine for hypertension. He experienced a skin rash and dysphoria while playing tennis after breakfast, and later became unconscious. He was admitted to the hospital and treated with hydrocortisone, which resolved his anaphylaxis. Further investigation revealed that he had allergies to ω5-gliadin, wheat, and gluten, but not to other foods. The man was diagnosed with food-dependent exercise-induced anaphylaxis secondary to amlodipine and was instructed to avoid wheat. After receiving antihistamine treatment, he no longer experienced anaphylaxis. [Extracted from the article]

A 12-year-old girl experienced refractory vasodilatory shock and drug intoxication after intentionally misusing amlodipine, resulting in an overdose. She presented to the emergency room with abdominal pain, vomiting, hypotension, tachycardia, and hypoxemia. The girl was hospitalized and treated with fluid resuscitation, oxygen therapy, and various medications. She developed anuric renal failure, acute respiratory distress syndrome, and multi-organ failure, but her condition improved with treatment including extracorporeal membrane oxygenation. After 21 days in the hospital, she was discharged. [Extracted from the article]

Author InformationAn event is serious (based on the ICH definition) when the patient outcome is:• * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important eventA 58-year-old man developed drug-induced gingival overgrowth during treatment with phenytoin for post-stroke epilepsy and amlodipine for hypertension [routes and duration of treatments to reaction onset not stated]. [Extracted from the article]

Author InformationAn event is serious (based on the ICH definition) when the patient outcome is:• * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important eventA 6-month-old boy exhibited a lack of efficacy following treatment with amlodipine, prazosin and propranolol for hypertension [routes and dosages not stated]. [Extracted from the article]

This article from Reactions Weekly describes two case reports of patients who experienced hypotension after overdosing on amlodipine and atenolol. The patients, a 50-year-old woman and a 45-year-old man, were treated with high-dose insulin therapy. The article does not provide details about the routes, dosages, duration of treatments, or outcomes of the patients. [Extracted from the article]

A 56-year-old man developed thrombotic thrombocytopenic purpura (TTP) while undergoing treatment for metastatic adenocarcinoma of the lung, hypertension, and Clostridium difficile colitis. He was receiving pembrolizumab, pemetrexed, amlodipine, and vancomycin. The patient initially responded well to combination therapy, but in November 2020, he was admitted with altered mental status and a low platelet count, leading to a diagnosis of TTP. He was treated with corticosteroids, plasma exchange, dexamethasone, rituximab, and resumed his lung cancer treatment without further TTP recurrence. [Extracted from the article]

A case report published in Reactions Weekly describes a man in his 40s who developed diabetes mellitus and a lichenoid drug eruption while being treated with nivolumab for metastatic melanoma and amlodipine for hypertension. The man presented with a rash and high blood glucose levels, and further examination revealed a widespread rash and glycosuria. The rash was attributed to nivolumab, while the lichenoid drug eruption was attributed to amlodipine and nivolumab. The man's hypertension medication was switched, and he received insulin and other medications to manage his diabetes. The report does not provide information on the outcome of the treatment. [Extracted from the article]

Eventually, his clonidine therapy was discontinued and started treatment with lisinopril along with continuation of amlodipine. Despite clonidine and amlodipine therapies, his blood pressure remained elevated, indicating lack of efficacy. [Extracted from the article]

As a result, his serum sodium level was raised to 139 mmol/L. Thereafter, the serum sodium levels remained stable at 138 mmol/L indicating resolution of hyponatraemia. During admission, serum sodium, serum potassium and serum creatinine levels were found to be at 127 mmol/L, 4.5 mmol/L and 1.24 mg/dL, respectively. After 10 days of the reinitiating of the flecainide, the serum sodium level to 129 mmol/L. Based on clinical presentation and laboratory test findings, et al. diagnosis of hyponatraemia, secondary to the flecainide therapy was concluded. [Extracted from the article]