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A 36-year-old man developed various toxicities, including osteonecrosis, moon facies, truncal obesity, and hyperglycemia, due to steroid dependence and drug misuse of prednisone and methylprednisolone during treatment for lower back pain. He also experienced steroid withdrawal syndrome. The man, a truck driver with a history of anterior cervical discectomy and fusion, presented with symptoms consistent with cauda equina syndrome. Despite his steroid dependence, he agreed to an extended steroid taper and rehabilitation, ultimately being discharged to an acute rehabilitation facility. [Extracted from the article]

A 40-year-old man experienced spinal cord infarction and cauda equina syndrome after a drug administration error involving triamcinolone, dexamethasone, lidocaine, and sodium chloride during treatment for chronic back pain. The error occurred during a caudal epidural block at an orthopedic clinic, leading to tingling sensations, bilateral leg paralysis, and other severe symptoms. Despite treatment with methylprednisolone and rehabilitation therapy, the man's motor, sensory, and bowel/bladder functions did not fully recover, highlighting the serious consequences of medication errors in medical procedures. [Extracted from the article]

A case report published in Reactions Weekly describes a woman in her 70s who exhibited lack of efficacy while being treated with niraparib for high-grade serous ovarian cancer. The woman initially received carboplatin and paclitaxel treatment and showed improvement, but later developed brain and spinal metastases. Despite receiving niraparib, her disease progressed, leading to the discontinuation of the medication. The woman received dexamethasone and irradiation, and while she reported some improvement, she ultimately died at home. [Extracted from the article]

A man in his 50s developed glial fibrillary acidic protein astrocytopathy after receiving the NVX-CoV-2373 COVID-19 vaccine. He experienced symptoms such as migrainous headache, anorexia, nausea, night sweats, malaise, cauda equina syndrome, hiccups, encephalopathy, and cranial neuropathies. Neuroimaging revealed brain stem, spinal cord, and cauda equina involvement, and his anti-glial fibrillary acidic protein antibody levels were strongly positive. The man was treated with methylprednisolone, plasmapheresis, and rituximab, leading to significant improvement in his condition. [Extracted from the article]

An 80-year-old man experienced a spontaneous spinal epidural hematoma (SSEDH) after receiving the COVID-19 vaccine from the Gamaleya National Research Center of Epidemiology and Microbiology. The man had a history of chronic kidney disease and developed symptoms such as cough, fever, shortness of breath, and sweating three days after receiving the vaccine. He later experienced a decrease in sensation and muscle strength in his lower limbs, as well as urinary and fecal incontinence. The man tested positive for COVID-19 and underwent surgery to remove the hematoma. Although the hematoma resolved, there was no improvement in his motor or sphincter function. The conclusion was that the SSEDH and associated symptoms were a result of the COVID-19 vaccine. [Extracted from the article]

An 80-year-old man developed a spontaneous spinal epidural hematoma (SSEDH) after receiving the COVID-19 vaccine from the Gamaleya National Research Center of Epidemiology and Microbiology. The man experienced symptoms such as cough, fever, shortness of breath, and sweating after his first dose of the vaccine. He later developed decreased sensation and muscle strength in his lower limbs, as well as urinary and fecal incontinence. The man was admitted to the emergency department and underwent surgery to remove the hematoma. Although the hematoma resolved, there was no improvement in his motor or sphincter function. The SSEDH was believed to be a result of the vaccine, and the man also experienced acute flaccid paralysis. [Extracted from the article]

A 61-year-old man experienced sepsis while undergoing treatment for choriocarcinoma with the drugs etoposide, ifosfamide, and cisplatin. The patient had pre-existing conditions including hypertension, chronic hepatitis C, and chronic obstructive pulmonary disease. He initially presented with symptoms of cauda equina syndrome and was subsequently diagnosed with choriocarcinoma. Despite completing the first cycle of chemotherapy and receiving antibiotics, his condition worsened and he eventually transitioned to comfort care. [Extracted from the article]

In this case-series, two patients with metastatic renal clear cell carcinoma (ccRCC) were described. The first patient, a 41-year-old man, developed autoimmune hepatitis and myocarditis while being treated with ipilimumab and nivolumab. The second patient, a woman in her 60s, exhibited lack of efficacy with multiple treatments for metastatic ccRCC. Both patients were later treated with belzutifan and showed positive responses. These cases highlight the potential side effects and treatment challenges associated with antineoplastic therapies for ccRCC. [Extracted from the article]

Two case studies were presented involving women who developed ankle swelling and proteinuria while being treated with amlodipine or cabozantinib for metastatic follicular carcinoma with cauda equina syndrome. In the first case, an 80-year-old woman experienced ankle swelling, tiredness, and poor appetite while taking amlodipine. The ankle swelling was attributed to amlodipine, and discontinuation of the medication was recommended. In the second case, a 71-year-old woman developed proteinuria due to cabozantinib, and discontinuation of the medication was also suggested. Regular monitoring of urine for proteinuria levels and the use of an angiotensin converting enzyme inhibitor were advised. [Extracted from the article]

Based on the preoperative imaging findings of posterior vertebral scalloping and heterogeneous signal intensity on MRI, the space-occupying lesion in the spinal canal was initially suspected to be a benign epidural or cauda equina tumour (e.g., schwannoma). Good clinical outcomes were maintained at the final 2-year postoperative follow-up, with MRI confirming the disappearance of the epidural space-occupying lesion. MRI was performed, which revealed a space-occupying lesion that extended from the right intravertebral region to the intraspinal canal at the level of the L4 vertebra on the right side. [Extracted from the article]

B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event In a case report 2 patients (including a man and a woman) aged 59-61 years were described who developed cauda equina syndrome (CES) following administration of lidocaine or bupivacaine for anaesthesia [ I durations of treatments to reactions onset not clearly stated i ]. Patient 2: (A 61-year-old woman): The woman underwent a right total knee arthroplasty using a femoral nerve block and general anesthesia. Notably, prior to surgery, he received epidural 1% lidocaine 5mL for anesthesia through a catheter in sitting position. [Extracted from the article]

Extended spectrum beta lactamase, I Escherichia coli i bacteria, along with I Staphylococcus i epidermidis revealed in wound culture [ I aetiology not stated i ], so he was transferred to the ICU and he was then treated with unspecified antibacterials [antibiotics], and heparin was necessitated for a bridging therapy to warfarin treatment. B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A 44-year-old man developed spontaneous subdural bleed with haemorrhagic thrombus during anticoagulant treatment with warfarin. Additionally, during anticoagulant treatment with heparin as bridging therapy to warfarin he developed resistance to heparin [ I dosages and routes not stated i ]. [Extracted from the article]

B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A 63-year-old man developed Cauda equina syndrome during treatment with triamcinolone, bupivacaine and sodium chloride for lumbar stenosis. Hence, he received epidural caudal sacral injection consisting of sodium chloride [normal saline] 10mL, triamcinolone 40mg and bupivacaine 8mL of 0.25%. Additionally, the fluid volume from injection containing triamcinolone, bupivacaine and sodium chloride, was thought to contribute in the cauda equina syndrome owing to immediate onset. [Extracted from the article]