Search

Dendrobium officinableKimura et Migo is a famous traditional herb medicine and is wildly used in folk as a tonic herb. Its endophytic fungi play prominent part in the function ofD.officinableKimura et Migo. In this study we first report the co-production of trichosetin (1), beauvericin (2), beauvericin A (3), enniatin B (4), enniatin H (5), enniatin I (6), enniatin MK1688 (7), fusaric acid (8) and dehydrofusaric acid (9) by the endophytic fungusFusariumsp. TP-G1 deriving from the root ofD.officinablekimura et Migo. These isolates’ reported bioactivities and the tested biological activities in this paper consisted with the functions ofD.officinableKimura et Migo. We found the MICs value of compounds1−7againstStaphylococcus aureusand MRSA showed nearly no difference, while compounds8−9were first found to have the antimicrobial activities againstAcinetobacter baumanniiwith a MIC value of 64 μg/mL and 128 μg/mL respectively. Compounds2,4,5and6were first found to show moderate anti-tumor activities against BL16F10; and compounds4and5were first found to show moderate anti-tumor activities against MCF-7. Furthermore, we report first here the isoleucine (Ile) replacement in beauvericin and enniatin will influence their antibacterial and brine shrimp lethality activities.

The ether extract ofArtemisia integrifoliawas separated by chromatography and afforded a new iridoid, arteintegin A (6), together with five known compounds, namely chamazulene (1) , acetylenes (E)-2, (E)-3, (Z)-4, eugenol (5). The structure elucidation of the new compound was carried out by 1D ( 1H NMR and 13C NMR) and 2D-NMR (COSY, HSQC and NOESY) spectral analysis .