1. Can intra-articular injection of freeze-dried platelet-derived factor concentrate regenerate articular cartilage in the knee joint?
- Author
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Yuki Kato and Tomohiko Shirata
- Subjects
0301 basic medicine ,Factor concentrate ,Biomedical Engineering ,Osteoarthritis ,Platelet-derived factor concentrate ,Knee Joint ,PRP, platelet-rich plasma ,Biomaterials ,03 medical and health sciences ,0302 clinical medicine ,Intra articular ,Platelet-rich plasma ,medicine ,Platelet ,lcsh:QH573-671 ,lcsh:R5-920 ,lcsh:Cytology ,business.industry ,PFC, platelet-derived factor concentrate ,Regeneration (biology) ,Cartilage ,medicine.disease ,030104 developmental biology ,medicine.anatomical_structure ,Intra-articular injection ,Anesthesia ,OA, osteoarthritis ,KOOS, Knee Injury and Osteoarthritis Outcome Score ,Original Article ,Knee osteoarthritis ,lcsh:Medicine (General) ,business ,human activities ,030217 neurology & neurosurgery ,Developmental Biology - Abstract
Freeze-drying methods not only enable the delivery of growth factors using platelets, but also extend the shelf-life of platelet concentrates. The present study shows the clinical results of treating knee osteoarthritis with freeze-dried platelet-derived factor concentrate (PFC). While it improved pain, activities of daily living, sports and recreational activities, and knee-related quality of life, it did not significantly improve symptoms other than pain, such as restricted range of motion and mechanical symptoms. As such, the treatment effect may be attributed to anti-inflammatory action rather than actual cartilage regeneration., Highlights • Intra-articular injection of freeze-dried PFC generally improved knee KOOS scores. • Pain, activities of daily living, sports and recreational activities, and knee-related quality of life improved. • However, symptoms other than pain, such as restricted range of motion and mechanical symptoms, did not improve.
- Published
- 2019