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Exploring the evolution of vegetation cover and its drivers in the Ferghana Basin helps to understand the current ecological status of the Ferghana Basin and to analyze the vegetation changes and drivers, with a view to providing a scientific basis for regional ecological and environmental management and planning. Based on GIMMS NDVI3g and meteorological data, the spatial and temporal evolution characteristics of NDVI were analyzed from multiple perspectives with the help of linear trend and Mann–Kendall (MK) test methods using arcgis and the R language spatial analysis module, combined with partial correlation coefficients and residual analysis methods to analyze the impacts of climate change and human activities on the regional vegetation cover of the Ferghana Basin from 1982 to 2015. NDVI driving forces. The results showed the following: (1) The growing season of vegetation NDVI in the Ferghana Basin showed an increasing trend in the 34-year period, with an increase rate of 0.0044/10a, and the spatial distribution was significantly different, which was high in the central part of the country and low in the northern and southern parts of the country. (2) Temperature and precipitation simultaneously co-influenced the vegetation NDVI growth season, with most of the temperature and precipitation contributing in the spring, most of the temperature in the summer being negatively phased and the precipitation positively correlated, and most of the temperature and precipitation in the fall inhibiting vegetation NDVI growth. (3) The combined effect of climate change and human activities was the main reason for the overall rapid increase and great spatial variations in vegetation NDVI in China, and the spatial distribution of drivers, namely human activities and climate change, contributed 44.6% to vegetation NDVI in the growing season. The contribution of climate change and human activities to vegetation NDVI in the Ferghana Basin was 62.32% and 93.29%, respectively. The study suggests that more attention should be paid to the role of human activities and climate change in vegetation restoration to inform ecosystem management and green development. [ABSTRACT FROM AUTHOR]