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Surface air temperature is a critical element in the surface–atmosphere interaction, energy exchange, and water cycle. Multi-source fusion reanalysis products (hereafter referred to as reanalysis) have spatiotemporal continuity and broad applicability that can provide key data support for various studies such as glacier melting, soil freeze-thaw and desertification, ecosystem, and climate change in the alpine region of the Qinghai–Tibet Plateau (QTP). Surface air temperature observations collected at 17 weather stations in the High-cold region Observation and Research Network for Land Surface Process and Environment of China (HORN) over the period of 2017–2018 are implemented to evaluate the advanced and widely used surface air temperature reanalysis datasets, which include the European Centre for Medium-Range Weather Forecasts (ECMWF) Fifth Generation Land Surface Reanalysis (ERA5L), the U.S. Global Land Data Assimilation System (GLDAS), and China Meteorological Administration Land Data Assimilation System (CLDAS). Results are as follows: (1) Evaluation results of temporal changes and spatial distribution characteristics indicate that the three reanalysis datasets are consistent with in-situ observations in the alpine region of the QTP. CLDAS is more consistent with observations and can better describe details of temperature distribution and variation than ERA5L and GLDAS. (2) For the evaluation period, CLDAS is 0.53 °C higher than the in-situ observation, while ERA5L and GLDAS are lower than the in-situ observation by −3.45 °C and −1.40 °C, respectively. (3) The accuracy of CLDAS is better than ERA5L and GLDAS under different elevations and land covers. We resampled three reanalysis datasets with a spatial resolution of 0.25° and used the two most common interpolation methods to analyze the impact of spatial resolution and different interpolation methods on the evaluation results. We found that the impact is small. In summary, the three reanalysis datasets all have certain applicability in the alpine region of the QTP, and the accuracy of CLDAS is significantly higher than ERA5L and GLDAS. The results of the present paper have important implications for the selection of reanalysis data in the studies of climate, ecosystem, and sustainable development in the QTP. [ABSTRACT FROM AUTHOR]