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We designed a workflow to investigate areas of potential neotectonic deformation, making use of well-developed techniques, but applied to a site characterized by low relief and low or moderate tectonic activity. In this pilot study, we targeted the Temiskaming Graben, in Eastern Canada, where recent and ongoing geophysical and sedimentological investigations have revealed recent activity along this ancient structure. The dataset compiled for this experimental study covers an area of nearly 147 square km across the provinces of Ontario and Quebec. For efficiency in terms of computational resources, we first performed cluster analysis on knickpoint location, identifying seven areas with a high density of disruptions along river profiles. We then performed more detailed morphometric analysis at 30 m resolution, identifying knickpoints along river profiles, calculating the hypsometric integral across the landscape with a moving window, and mapping and comparing lineaments with known structural features. The results of our workflow showed that these three techniques can be efficiently combined for neotectonic analysis, and the synergistic approach strengthens the reliability and accuracy of our results. Our research extends the application of morphometric analysis, commonly used for exploring areas with intense tectonism and high topography, to areas that are characterized by low relief and low or moderate tectonic activity. The new areas identified with the workflow proposed in this research require ground-truthing through mapping and shallow geophysical investigations. [ABSTRACT FROM AUTHOR]