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High Mountain Asia (HMA), with its high altitude, widely distributed snow and frozen soil, influences the climate of the northern hemisphere and even the world through thermal balance and the water vapor cycle and is also an indicator of global climate change. The influence of HMA snow cover on its surrounding areas has always been a research hotspot. Taking the Yangtze River Basin (YRB) of China as an example, this paper analyzes the relationship between winter snow depth in HMA and drought and flood in spring and summer in the YRB in the recent 40 years by using Singular Value Decomposition (SVD). The results show that the influence of snow cover on drought and flood in spring is inversely different between eastern and western parts of HMA, while the effect in summer is consistent. When the snow depth is larger (smaller) in the east and smaller (larger) in the west in winter, the YRB is drier (wetter) in spring. When the overall snow depth in HMA is larger (smaller) in winter, the northern part of the middle and lower reaches of the YRB is drier (wetter) in summer. The results provide support for understanding the impact of HMA snow cover on the surrounding climate and some important indicators for drought and flood prediction in the YRB. [ABSTRACT FROM AUTHOR]