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Landslide classification and identification along Karakorum Highway (KKH) is still challenging due to constraints of proposed approaches, harsh environment, detail analysis, complicated natural landslide process due to tectonic activities, and data availability problems. A comprehensive landslide inventory and a landslide susceptibility mapping (LSM) along the Karakorum Highway were created in recent research. The extreme gradient boosting (XGBoost) and random forest (RF) models were used to compare and forecast the association between causative parameters and landslides. These advanced machine learning (ML) models can measure environmental issues and risks for any area on a regional scale. Initially, 74 landslide locations were determined along the KKH to prepare the landslide inventory map using different data. The landslides were randomly divided into two sets for training and validation at a proportion of 7/3. Fifteen landslide conditioning variables were produced for susceptibility mapping. The interferometric synthetic aperture radar persistent scatterer interferometry (PS-InSAR) technique investigated the deformation movement of extracted models in the susceptible zones. It revealed a high line of sight (LOS) deformation velocity in both models' sensitive zones. For accuracy comparison, the area under the curve (AUC) of the receiver operating characteristic (ROC) curve approach was used, which showed 93.44% and 92.22% accuracy for XGBoost and RF, respectively. The XGBoost method produced superior results, combined with PS-InSAR results to create a new LSM for the area. This improved susceptibility model will aid in mitigating the landslide disaster, and the results may assist in the safe operation of the highway in the research area. [ABSTRACT FROM AUTHOR]