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Evaluating the efficacy of air pollution control policies is an essential part of the decision-making process to develop new policies and improve existing measures. Since 2005, Fujian Province of Mainland China and Taiwan across the Taiwan Strait have both implemented aggressive air pollution control policies designed based on different principles, but a comprehensive evaluation of these control policies on PM 2.5 pollution levels is still lacking. In the current study, we assessed the effects of these policies in the Taiwan Strait Region from 2005 to 2018 using full-coverage, high-resolution PM 2.5 generated by a satellite-driven machine learning model. A ten-fold cross-validation for our prediction model showed an R 2 value of 0.89, demonstrating that these predictions can be used for policy evaluation. During the 14-year period, PM 2.5 levels in all areas of Fujian and Taiwan underwent a significant decrease. Separate regression models for policy evaluation in Taiwan and Fujian showed that all considered policies have mitigated PM 2.5 pollution to various degrees. The Clean Air Action Plans (CAAP) is the most effective control policy in Taiwan, while the Action Plan of Air Pollution Prevention and Control (APPC-AP) and Three-year Action Plan for Blue Skies (3YAP-BS) as well as their provincial implementation plans are the most successful in Fujian. The effectiveness of control policies, however, varies by land-use types especially for Taiwan. • PM 2.5 levels were estimated in the Taiwan Strait Region at 1-km resolution from 2005 to 2018 • The most effective control policies to lower PM 2.5 levels in Taiwan and Fujian were analyzed • The effectiveness of control policies varies by land use type in Taiwan [ABSTRACT FROM AUTHOR]