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We investigated normalized difference vegetation index data from the NOAA series of Advanced Very High Resolution Radiometers and found regions in North America that experienced marked increases in annual photosynthetic capacity at various times from 1982 to 2005. Inspection of these anomalous areas with multi-resolution data from Landsat, Ikonos, aerial photography, and ancillary data revealed a range of causes for the NDVI increases: climatic influences; severe drought and subsequent recovery; irrigated agriculture expansion; insect outbreaks followed by logging and subsequent regeneration; and forest fires with subsequent regeneration. Vegetation in areas in the high Northern Latitudes appear to be solely impacted by climatic influences. In other areas examined, the impact of anthropogenic effects is more direct. The pattern of NDVI anomalies over longer time periods appear to be driven by long-term climate change but most appear to be associated with climate variability on decadal and shorter time scales along with direct anthropogenic land cover conversions. The local variability of drivers of change demonstrates the difficulty in interpreting changes in NDVI and indicates the complex nature of changes in the carbon cycle within North America. Coarse scale analysis of changes could well fail to identify the important local scale drivers controlling the carbon cycle and to identify the relative roles of disturbance and climate change. Our results document regional land cover land use change and climatic influences that have altered continental scale vegetation dynamics in North America. [Copyright &y& Elsevier]