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Start Over Author "D, Royere" Journal reproductive biomedicine online
3 results on '"D, Royere"'

1. Efficacy of IVF using frozen donor semen in cases of previously failed DI cycles compared with tubal infertility: a cohort study

Author

F Guerif, MH Saussereau, C Barthelemy, ML Couet, O Gervereau, J Lansac, and D Royere

Subjects
Adult, Male, Infertility, medicine.medical_specialty, Donor insemination, Fertilization in Vitro, Cohort Studies, Donor semen, Pregnancy, medicine, Humans, reproductive and urinary physiology, Cryopreservation, Gynecology, urogenital system, Obstetrics, business.industry, Female infertility, Infant, Newborn, Obstetrics and Gynecology, Fallopian Tube Diseases, Successful pregnancy, medicine.disease, female genital diseases and pregnancy complications, Reproductive Medicine, Cohort, Insemination, Artificial, Heterologous, Female, Live birth, business, Infertility, Female, Follow-Up Studies, Semen Preservation, Developmental Biology, Cohort study
Abstract

A cohort follow-up study was designed to compare the efficacy of IVF using frozen donor semen (IVF-D) following previously failed DI cycles (unexplained female infertility) and direct IVF-D treatment because of tubal infertility (control group). The cohort comprised 189 couples initiating IVF-D after previously failed DI cycles (n = 126) or directly (n = 63). Couples were followed until completion (success or drop-out for personal or medical reasons). Live births and drop-out were expressed both as rate per cycle and crude cumulative rate. Characteristics of IVF-D cycles were similar between the two groups. Moreover, overall outcome was also similar in terms of crude cumulative live birth rate (54.0 versus 57.1% for failed DI cycles and tubal infertility groups respectively). This is the first report on crude cumulative live birth rate based on a cohort follow-up study in unexplained previously failed DI cycles and tubal infertility. Previously failed DI cycles did not impair the chances of achieving a successful pregnancy using IVF-D in this series. Slight oocyte dysfunction, which might underlie the failure of DI cycles, might be overcome using IVF-D.

Published
2004
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2. Does early morphology provide additional selection power to blastocyst selection for transfer?

Author

Guerif F, Lemseffer M, Leger J, Bidault R, Cadoret V, Chavez C, Gasnier O, Saussereau MH, and Royere D

Subjects
Birth Rate, Embryo Implantation, Female, Humans, Pregnancy, Prospective Studies, Blastocyst ultrastructure, Embryo Transfer methods, Embryonic Development
Abstract

Routine early developmental parameters are widely used in IVF centres to evaluate embryo development and fresh single-blastocyst transfer currently seems superior to single-embryo transfer. Would early morphological parameters help to choose the single blastocyst to be transferred, thereby improving the chances of implantation and live birth rate? This prospective observational study analysed the individual outcomes of 2617 embryos from 511 IVF couples scheduled for a single-blastocyst transfer. Embryo and blastocyst scores were constructed. There was a clear relationship between the kinetics and morphology of blastocysts and further implantation and live birth rate. There was a limited predictive value of embryo score with regard to blastocyst development and growth kinetics. Implanted and non-implanted blastocysts showed similar embryo scores. Thus usual morphological parameters on days 1 and 2 seem to have no additional value in indicating the right blastocyst to transfer. Non-invasive approaches might be helpful to increase the chances of implantation in the future., (Copyright © 2010 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.)

Published
2010
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3. Efficacy of blastocyst transfer after implantation failure.

Author

Guerif F, Bidault R, Gasnier O, Couet ML, Gervereau O, Lansac J, and Royere D

Subjects
Adult, Birth Rate, Embryo Culture Techniques, Embryo, Mammalian cytology, Female, Humans, Pregnancy, Pregnancy Rate, Retreatment, Sperm Injections, Intracytoplasmic, Time Factors, Treatment Failure, Treatment Outcome, Embryo Implantation, Embryo Transfer, Fertilization in Vitro
Abstract

Clinicians who treat unsuccessful couples despite repeated transfers of good quality embryos face a challenge. Among the various strategies that have been described, embryo transfer at the blastocyst stage has been postulated to improve implantation. A prospective non-randomized analysis was performed in 276 IVF patients who failed to conceive after at least two early embryo transfers of at least two grade 1-2 embryos per cycle. For the next attempt, couples chose between day 2 embryo transfer (D2 group; n = 147) and day 5/6 blastocyst transfer (D5/D6 group; n = 129) before starting the following attempt. Embryo quality was assessed and results were expressed as clinical pregnancy, live birth and implantation rates per cycle. Embryo grade 1 number was similar between both groups, whereas mean embryo score of the whole cohort was slightly higher in the D2 group. The live birth rates per cycle (27.9 versus 19.7%) and implantation rates per cycle (25.4 versus 12.4%) were higher in the D5/D6 group compared with the D2 group. Improved embryo selection and uterine receptivity may explain the additional benefit of embryo transfer at the blastocyst stage for couples with repeated implantation failures.

Published
2004
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