1. Live birth of twins after IVF of oocytes that were cryopreserved almost 12 years before
- Author
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Inés Carretero, M.J. Donaldson, Marcos Horton, R. Sergio Pasqualini, R Agustín Pasqualini, C.J. Quintans, and M. Fernanda Urquiza
- Subjects
medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,Intracytoplasmic sperm injection ,Cryopreservation ,Andrology ,Pregnancy ,medicine ,Humans ,Sperm Injections, Intracytoplasmic ,reproductive and urinary physiology ,Gynecology ,Slow freezing ,business.industry ,Term pregnancy ,Obstetrics and Gynecology ,Embryo ,Middle Aged ,Embryo Transfer ,Reproductive Medicine ,embryonic structures ,Oocytes ,Pregnancy, Twin ,Ectogenesis ,Female ,business ,Live birth ,Infertility, Female ,Live Birth ,Developmental Biology ,Low sodium - Abstract
A 45-year-old woman received embryos from IVF by intracytoplasmic sperm injection (ICSI) with her own oocytes that were cryopreserved (slow freezing in a low-sodium medium) 11 years and 7 and a half months before, when she was 33 years old. From seven metaphase-II oocytes thawed, five survived, four were fertilized after ICSI and two cleaving embryos were transferred on day 3. A diamniotic dichorionic term pregnancy was achieved, ending with the delivery of two healthy girls. As far as is known, this case represents, to date, the longest storage period of cryopreserved human oocytes resulting in a live birth.
- Published
- 2012