1. Family-based analysis of INSR polymorphisms in Chinese PCOS.
- Author
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Jing Dua, Jianfeng Wang, Xuedong Sun, Xinghua Xu, Feng Zhang, Bin Wang, Yuhua Shi, and Zi-jiang Chen
- Subjects
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INSULIN receptors , *POLYCYSTIC ovary syndrome , *CHINESE people , *SINGLE nucleotide polymorphisms , *HIGH density lipoproteins , *DISEASES - Abstract
The insulin receptor (INSR), which is an indispensable component of the insulin-signalling pathway, could be a plausible candidate gene for polycystic ovary syndrome (PCOS). This study was designed to determine whether an association exists between three SNP variants (rs3786681, rs17253937 and rs2252673) of the INSR gene and PCOS in Han Chinese. A total of 224 family trios (672 participants in total) were enrolled in this family-based transmission disequilibrium test. Genotypes were obtained by sequencing. A weak association was detected in rs2252673 (P = 0.027), which indicated that INSR may confer an increased susceptibility to PCOS in Chinese. Additionally, the association between INSR gene variants and clinical and metabolic characteristics of women with PCOS was investigated. Carriers of the CG and GG genotypes in women with PCOS were slightly associated with higher cholesterol concentration (t = 2.072, P = 0.048) and lower high-density lipoprotein cholesterol concentration (t = 2.274, P = 0.026). The minor allele conferred increased odds of PCOS independently of body mass index. The present data may provide a basis for further studies of the role of the INSR in the aetiology of PCOS. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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