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In view of deficiencies of current column chromatography apparatus, the improvement was proposed correspondingly. The column chromatography apparatus can avoid phenomenon of dry column effectively and the requirements of purification for temperature can be satisfied by level alarm and chromatographic column with interlayer. The improved experimental device improves the efficiency of separation and purification. The practice shows that students can not only develop innovative consciousness on the common experiment for medicinal chemistry of natural products, but also set up protection consciousness of independent intellectual property during designing the device which greatly promote the organic combination of innovative experiment, design experiment and basic experiment. This pattern has certain enlightenment value for the cultivation of application and innovative pharmaceutical talents. The column chromatography device with temperature control and alarm function has characteristics of high efficiency and green, energy saving. The creation obtained the certificate of national utility model patent. [ABSTRACT FROM AUTHOR]