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CONVENTIONALLY, UC IS RECOGNIZED AS A DISEASE WITH CONTINUOUS MUCOSAL INFLAMMATION THAT EXTENDS FROM THE RECTUM TO THE PROXIMAL PART OF THE COLON, BUT DURING THE LAST DECADE, A PARTICULAR PATTERN OF COLITIS THAT INVOLVES THE DISTAL COLON WITH A NORMAL APPEARANCE MUCOSA INTERPOSED AND A WELL DEFINED AREA OF INFLAMMATION AROUND THE APPENDIX HAS BEEN HIGHLIGHTED. WE USED A TERTIARY CARE CENTER EVIDENCES TO ANALYZE THE CHARACTERISTICS OF UC PATIENTS WITH PARP. WE EVALUATED 76 PATIENTS WHO WENT TO OUR CLINIC FOR INVESTIGATING CHRONIC DIARRHEA SYNDROME BETWEEN JANUARY 2018-DECEMBER 2020 AND FOR WHOM A DIAGNOSIS OF ULCERATIVE COLITIS WAS ESTABLISHED. ONLY 7 PATIENTS HAD ENDOSCOPICALLY ASPECT OF PARP (THIS HAPPENED DURING FOLLOW-UP ENDOSCOPY), ASPECT SUPPORTED ALSO BY THE HISTOLOGICAL DESCRIPTION (NANCY INDEX SCORE). DURING FOLLOW-UP, MOST PATIENTS WITH PARP KEPT THE SAME EXTENT OF LESIONS. CONCLUSIONS: WE CONFIRM THE PRESENCE OF PARP AS A "SKIP LESION" IN DISTAL UC, DIAGNOSTIC SUPPORTED ALSO BY THE HISTOPATHOLOGIST, AND EVEN THOUGH WE ARE CONFIDENT IN THE DIAGNOSIS OF ULCERATIVE COLITIS, ONE PATIENT HAD A CROHN'S DISEASE PHENOTYPE SWITCH DURING THE EVOLUTION. NONETHELESS, WE CANNOT CONCLUDE THAT PARP HAS A ROLE IN THE EXTENSION OF LESIONS, REMISSION OR RELAPSE OF DISEASE, GIVEN THE FACT THAT WE DO NOT HAVE A SUFFICIENT GROUP OF ELIGIBLE PATIENTS, FOR WHICH REASON DETAILED STUDIES ARE NEEDED. [ABSTRACT FROM AUTHOR]

THE CORRECT EXAMINATION, BY AN ANATOMOPATHOLOGIST WITH EXPERTISE IN INFLAMMATORY BOWEL DISEASES, OF BIOPSIES OR RESECTION PIECES IS OF OVERWHELMING IMPORTANCE FOR ESTABLISHING THE DEFINITE DIAGNOSIS, BUT ALSO CONSIDERING MANAGEMENT STRATEGIES AND SUBSEQUENT SURVEILLANCE OF THE PATIENT, GIVEN THE FACT THAT THERE IS A POSSIBILITY OF PROGRESSION OF DYSPASTIC LESIONS TO ADENOCARCINOMA, IN THE LONGSTANDING DISEASE. THE RISK OF COLORECTAL CANCER IS CUMULATIVE, ESPECIALLY IN ULCERATIVE COLITIS, AS THE YEARS PASS, SO BIOPSIES FROM SUSPICIOUS AREA SHOULD BE TAKEN, WHENEVER NEEDED. REGULAR ENDOSCOPIC FOLLOW-UP IS RECCOMENDED BY THE NTERNATIONAL GUIDELINES AND SHOULD BE TAILORED TO EACH INDIVIDUAL, TAKING INTO ACCOUNT THE RISK FACTORS, THE DETECTION OF DYSPALSIA BEING THE MOST IMPORTANT GOAL OF SURVEILLANCE COLONOSCOPY. EARLY IDENTIFICATION OF DYSPLASIA (MACROSCOPICALLY VISIBLE OR NOT) IS THE CORNERSTONE OF REDUCING THE RISK OF COLORECTAL CANCER. IN RECENT YEARS, SEVERAL NEW TYPES OF UNCONVENTIONAL DYSPLASIA HAVE BEEN RECOGNIZED, BUT EXACT MORPHOLOGIC CRITERIA ARE REQUIRED. OF ALL PATTERNS ENCOUNTERED, THE HYPERMUCINOUS DYSPLASIA HAS BEEN THE MOST COMMONLY DETECTED AND DESCRIBED. THE ASSOCIATION WITH CLASSIC DYSPLASIA OR EVEN COLORECTAL CANCER IS STILL NOT ENOUGH STUDIED SO FAR. [ABSTRACT FROM AUTHOR]

PREVIOUS STUDIES HAVE SHOWN A VARIETY OF RISK FACTORS THAT MAY BE INVOLVED IN THE AETIOLOGY OF PANCREATIC NEOPLASIA. WE EXAMINED RISK FACTORS FOR PANCREATIC CANCER IN A CASE-CONTROL STUDY CONDUCTED IN FUNDENI CLINICAL INSTITUTE BETWEEN SEPTEMBER 2016 AND SEPTEMBER 2018, THAT INCLUDED 74 INCIDENT CASES AND 74 CONTROLS ADMITTED FOR NONNEOPLASTIC DISEASES, FREQUENCY-MATCHED TO CASES BY SEX AND AGE. LOGISTIC REGRESSION MODELS WERE USED FOR MULTIVARIATE OR SUCH AS SEX, AGE, DIABETES, VIRAL HEPATITIS, SMOKING AND ALCOHOL CONSUMPTION STATUS, AND OTHER PERSONAL AND FAMILIAL HISTORY. OUR FINDINGS SUPPORT PREVIOUS STUDIES INDICATING THAT DIABETES IS A RISK FACTOR FOR PANCREATIC CANCER (OR 4.8, P<0.05). CHOLECYSTECTOMY ALSO APPEARED TO BE A RISK FACTOR, SUBJECTS WITH A CHOLECYSTECTOMY AT LEAST 20 YEARS PRIOR TO THE DIAGNOSIS OF PANCREATIC CANCER EXPERIENCED AN INCREASED RISK, WHICH WAS MARGINALLY SIGNIFICANT. IN CONTRAST, SIGNIFICANT 2- FOLD (P<0.05) REDUCED RISK WAS ASSOCIATED WITH ALLERGIES. IN ADDITION, WE OBSERVED SIGNIFICANTLY INCREASED RISKS FOR SUBJECTS WHO SMOKED OR ARE CURRENTLY SMOKING. THIS STUDY DEMONSTRATES THE ROLE AS RISK FACTORS OF SOME ENVIRONMENTAL FACTORS, PERSONAL AND FAMILIAL HISTORY, BUT THESE ASSOCIATIONS, HOWEVER, MAY BE DUE TO CHANCE SINCE THE NUMBER OF INDIVIDUALS INCLUDED IN THE STUDY IS REDUCED. [ABSTRACT FROM AUTHOR]

PREVIOUS STUDIES HAVE SHOWN A VARIETY OF RISK FACTORS THAT MAY BE INVOLVED IN THE AETIOLOGY OF PANCREATIC NEOPLASIA. WE EXAMINED RISK FACTORS FOR PANCREATIC CANCER IN A CASE-CONTROL STUDY CONDUCTED IN FUNDENI CLINICAL INSTITUTE BETWEEN SEPTEMBER 2016 AND SEPTEMBER 2018, THAT INCLUDED 74 INCIDENT CASES AND 74 CONTROLS ADMITTED FOR NONNEOPLASTIC DISEASES, FREQUENCY-MATCHED TO CASES BY SEX AND AGE. LOGISTIC REGRESSION MODELS WERE USED FOR MULTIVARIATE OR SUCH AS SEX, AGE, DIABETES, VIRAL HEPATITIS, SMOKING AND ALCOHOL CONSUMPTION STATUS, AND OTHER PERSONAL AND FAMILIAL HISTORY. OUR FINDINGS SUPPORT PREVIOUS STUDIES INDICATING THAT DIABETES IS A RISK FACTOR FOR PANCREATIC CANCER (OR 4.8, P<0.05). CHOLECYSTECTOMY ALSO APPEARED TO BE A RISK FACTOR, SUBJECTS WITH A CHOLECYSTECTOMY AT LEAST 20 YEARS PRIOR TO THE DIAGNOSIS OF PANCREATIC CANCER EXPERIENCED AN INCREASED RISK, WHICH WAS MARGINALLY SIGNIFICANT. IN CONTRAST, SIGNIFICANT 2- FOLD (P<0.05) REDUCED RISK WAS ASSOCIATED WITH ALLERGIES. IN ADDITION, WE OBSERVED SIGNIFICANTLY INCREASED RISKS FOR SUBJECTS WHO SMOKED OR ARE CURRENTLY SMOKING. THIS STUDY DEMONSTRATES THE ROLE AS RISK FACTORS OF SOME ENVIRONMENTAL FACTORS, PERSONAL AND FAMILIAL HISTORY, BUT THESE ASSOCIATIONS, HOWEVER, MAY BE DUE TO CHANCE SINCE THE NUMBER OF INDIVIDUALS INCLUDED IN THE STUDY IS REDUCED. [ABSTRACT FROM AUTHOR]

CANCER OF THE EXOCRINE PANCREAS IS A HIGHLY LETHAL MALIGNANCY. SURGICAL RESECTION IS THE ONLY POTENTIALLY CURATIVE TREATMENT. UNFORTUNATELY, BECAUSE OF THE LATE PRESENTATION, ONLY 15 TO 20 PERCENT OF PATIENTS ARE CANDIDATES FOR PANCREATECTOMY. THE AIM OF OUR STUDY WAS TO REVIEW THE RISK FACTORS, CLINICAL PRESENTATION, DIAGNOSTIC TOOLS AND THERAPEUTIC APPROACH OF PATIENTS WITH PANCREATIC CANCER, ADMITTED TO OUR CLINIC BETWEEN JANUARY 1ST AND DECEMBER 31ST OF 2016. WE ENROLLED TWO HUNDRED AND SIXTY EIGHT CONSECUTIVE PATIENTS. WE FOUND THAT MOST PATIENTS PRESENTED AT LEAST ONE RISK FACTOR FOR PANCREATIC NEOPLASIA, ESPECIALLY CIGARETTE SMOKING AND ALCOHOL DRINKING. MANY PATIENTS WERE DIAGNOSED IN ADVANCED STAGES OF THE DISEASE, WHEN THE TUMOR WAS LOCALLY INVASIVE OR HAD DISTANT METASTASES. THE MOST FREQUENT HISTOLOGICAL TYPE WAS ADENOCARCINOMA, FOLLOWED BY NEUROENDOCRINE TUMORS (13.36%). PATIENTS BENEFITED FROM SURGICAL, ONCOLOGICAL, AND/OR ENDOSCOPIC TREATMENT. THE MEDIAN SURVIVAL TIME WAS 8.83 MONTHS FOR ADENOCARCINOMA AND 66.34 MONTHS FOR NEUROENDOCRINE TUMORS. WE NOTED A LONGER MEDIAN SURVIVAL TIME FOR ADENOCACINOMA THAN THE EUROPEAN AVERAGE OF 4.6 MONTHS, PROBABLY DUE TO THE FACT THAN PATIENTS WERE DIAGNOSED AND TREATED BY A MULTIDISCIPLINARY TEAM, IN A TERTIARY CARE FACILITY. HOWEVER WE NEED TO DO A BETTER JOB IN IDENTIFYING HIGH RISK INDIVIDUALS AND THEN OFFERING THEM A PERSONALISED SCREENING PROGRAM, IN ORDER TO DIAGNOSE MORE PATIENTS IN POTENTIALLY CURATIVE STAGES. [ABSTRACT FROM AUTHOR]

THE PURPOSE OF THIS PAPER IS TO CLARIFY THE PARAMETERS USED FOR A DIFFERENTIAL DIAGNOSIS BETWEEN CROHN`S COLITIS AND ULCERATIVE PANCOLITIS AND TO IDENTIFY THOSE WITH THE HIGHEST DIAGNOSTIC VALUE. THE IMPORTANCE OF THE STUDY WILL BE REFLECTED IN LOWER RATES OF DIAGNOSIS DELAY, LOWER RATE OF LONGTERM COMPLICATIONS AND INTO A BETTER THERAPEUTIC APPROACH. THIS IS A RETROSPECTIVE STUDY, WHICH WAS PERFORMED ON 54 PATIENTS DIAGNOSED WITH CROHN`S COLITIS OR ULCERATIVE PANCOLITIS, WHO WERE ANALYZED EPIDEMIOLOGICALLY AND PHENOTYPICALLY. THEY WERE DIVIDED IN 2 GROUPS AND COMPARED BASED ON THE ENDOSCOPICAL AND HISTOLOGICAL CHARACTERISTICS. THE ENDOSCOPIC LESIONS WITH THE HIGHEST DIAGNOSTIC VALUE FOR CROHN`S WERE FOUND TO BE THE LONGITUDINAL AND DEEP ULCERS, AND ALSO, HIGHER SEVERITY OF LESIONS THE ON THE RIGHT COLON. AS FOR ULCERATIVE PANCOLITIS HISTOPATHOLOGICAL CHARACTERISTICS WITH THE HIGHEST DIAGNOSTIC VALUE WERE FOUND TO BE THE ASSIMTERICAL AN DIFFUSE DISTRIBUTION OF ARCHITECTURAL CHANGES, CRIPTITIS AND CRYPTIC ABSCESSES. THE EPITHELIOID GRANULOMA, ONCE CONSIDERED GOLD STANDARD FOR A DIAGNOSIS OF CROHN`S DISEASE IS RARELY ENCOUNTERED ON THE TISSUE SAMPLES FROM COLONIC BIOPSIES. BASAL PLASMOCITOSIS IS PRESENT IN BOTH DISEASES, BEING A MARKER OF CHRONIC COLITIS AND HAVING NO SPECIFICITY FOR CROHN`S OR ULCERATIVE COLITIS. [ABSTRACT FROM AUTHOR]