1. Catastrophic antiphospholipid syndrome in an immune thrombocytopenia patient treated with avatrombopag.
- Author
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Van de Vondel S, Vandenbriele C, Gheysens G, Verhamme P, and Janssens A
- Abstract
Background: Avatrombopag is an orally administered second-generation thrombopoietin receptor agonist (TPO-RA) approved for the treatment of chronic immune thrombocytopenia (ITP). However, increased thrombogenicity in patients with ITP after initiation of TPO-RA treatment has been reported., Key Clinical Question: We report a case of a patient with ITP who developed a catastrophic antiphospholipid antibody syndrome (CAPS), following treatment with avatrombopag., Clinical Approach: A20-year-old known chronic patient with ITP presented at the emergency department with a 2-week history of headache, nausea, and abdominal pain, 3 weeks after initiating avatrombopag. In-hospital diagnostic work-up revealed multiple microvascular thrombotic events, including myocardial, cerebrovascular, and pulmonary infarctions. Laboratory test results showed a triple-positive antiphospholipid antibodies serology., Conclusion: The diagnosis of probable avatrombopag-associated CAPS was made., (© 2023 The Authors.)
- Published
- 2023
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