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1. Immunological and Clinical Effect of Long-Term Oral Treatment with RU 41740 in Patients with Chronic Bronchitis: Double-Blind Trial Long-Term versus Standard Dose Regimen

Author

M. Uccelli, Anna Fietta, C. Merlini, G. Gialdroni Grassi, and Carlo Grassi

Subjects
Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Chronic bronchitis, Time Factors, Phagocytosis, medicine.medical_treatment, Dose-Response Relationship, Immunologic, Administration, Oral, Gastroenterology, Drug Administration Schedule, law.invention, Bacterial Proteins, Double-Blind Method, Randomized controlled trial, law, Internal medicine, medicine, Humans, Bronchitis, Aged, Aged, 80 and over, Chemotherapy, business.industry, Respiratory disease, Middle Aged, medicine.disease, Surgery, Regimen, Tolerability, Chronic Disease, Female, business
Abstract

The immunological and clinical effects of two oral treatment schedules of RU 41740 (standard for 3 months vs. long-term for 6 months) were assessed in 40 patients with chronic bronchitis by a controlled, double-blind, randomized trial. Both treatments significantly improved phagocytosis index of both neutrophils and monocytes, and the phagocytosis frequency and the candidacidal activity of neutrophils, showing the maximum stimulation at the end of the third course of treatment. Both treatment schedules reduced the number and the duration of infectious exacerbations of chronic bronchitis with respect to those observed in the corresponding period of the previous year. However, no significant difference between standard and long-term treatment with RU 41740 was found with respect to the immunological and clinical effect and tolerability.

Published
1992
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6. Contents, vol. 50, Supplement 2, 1986

Author

M. Noto, S. Shimura, W. Shaqadan, M. Pasargiklian, G. Ciappi, P. Guerzoni, J.G. Widdicombe, A.W. Bodas, W. Fasano, S.M. Distefano, Helen Ramsdale, J.P. Delwiche, R. Carnimeo, A. Mistretta, Giorgio Segre, Virginia De Rose, C. Sena, Esko Huhti, Peter Sterk, C. Tantucci, Jorge Torres, N. Alessi, Patrizia Mangiarotti, G. Peralta, N. Del Bono, P. Carnicelli, L. Cervone, M.P. Foschino Barbaro, S. Bianco, P. Gaicomelli, Ulf Pipkorn, C. Vancheri, H. Inoue, V. Massei, Enrico Maggi, M. Robuschi, E. Angelici, P. Magnini, R. Barnabè, P. Hedqvist, A. Bisetti, G. Funaro, F. Cresci, Giuliana Gialdroni Grassi, J. Garcia Barbal, S. Valente, Y. Shimizu, G.E. Marlin, B. Jenner, W. Hida, A. Pesci, E. Fornai, F. Peccini, J. Prignot, N. Pulerà, O. Taguchi, Robert M. Naclerio, L. Marazzini, Y. Okazaki, R. Pinto, Peter J. Barnes, M. Scarpitta, Robert P. Schleimer, F.L. Dente, C. Cavalieri, G. Fontana, G. Bertorelli, W.T. Ulmer, P. Noceti, S. Sensi, J. Diaz, J.A. Nadel, J. Lulling, R. Pulejo, C. Serra, L. Toscano, G. Culla, V. Bellia, G. De Cataldis, Sven-Erik Dahlén, J. Crane, F. Madsen, S. Carlone, N. Crimi, L. Frølund, A.L. De Masi, M. Cervone, G. Virgili, A. Vaghi, Myrna Dolovich, H. Sasaki, P. Panuccio, K.B.P. Leung, A. Grieco, Kari Sahlström, M. Mugnai, F. Bergero, F. Bariffi, B. Cacopardo, T. Takishima, Pietro Zanon, Frederick E. Hargreave, F. Palermo, S. Mirabelli, G.H. Russo, H. Nogami, A. Santolicandro, M. Rossi, P.A. Frith, Gian Franco Del Prete, L. Del Bono, T. Sasaki, D. Pérez, P.E.P. Dubois, C. Giuntini, E Adelroth, L. Del Torre, Stephen C. Lazarus, M. Lelli, C.A. Bellía, S. De Luca, K.C. Flint, A. Sanduzzi, J. Brostoff, Juan Antonio Mazzei, Mario Ricci, A. Petraglia, L. Romano, N.McI. Johnson, Anna Fietta, R.C. Calvanese, C.M. Sanguinetti, E.R. McFadden, P. Palange, Stephen P. Peters, D. Ansalone, Elisabeth Granström, J.L. Calpe, U.G. Svendsen, B. Mastropasqua, Warren M. Gold, M. Bozzoni, B. Bruni, P. Simone, F. Patalano, D.C. Flenley, Risto Härkönen, P. Minette, B. Weeke, G. Garofalo, E. Longhini, A. Baronti, G.N. Colasurdo, V. Picca, Lawrence M. Lichtenstein, Kari Alanko, G. Bonsignore, A. Mori, M. Moretti, Sergio Romagnani, R. Aquilina, C. Ciccarello, L. Cecere, Paul M. O'Byrne, C.F. Marchioni, O. Resta, D. McIntosh, F.L. Pearce, G. Luciani, A. Giacopelli, P. Vergara, T. Todisco, E. Servera, M. Newhouse, J. Atkinson, P. Serra, S. Gasparini, G. De Matthaeis, John M. Shneerson, B.N. Hudspith, Maria Kumlin, M. Pirrelli, Donald W. MacGlashan, S. Macaluso, N. Carnimeo, F. De Benedetto, E. Marangio, G. Migliara, M.E. D’Amore, G.M Corbo, M. Marchioni, Carlo Grassi, J. Marín, Anneli Poukkula, and V. Grassi

Subjects
Pulmonary and Respiratory Medicine, Traditional medicine, business.industry, Medicine, business
Published
1986
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7. Evaluation of the Host Defense System in Asthmatic Patients

Author

Pietro Zanon, Carlo Grassi, Giuliana Gialdroni Grassi, Virginia De Rose, P. Mangiarotti, and Anna Fietta

Subjects
Adult, Male, Pulmonary and Respiratory Medicine, Adolescent, Neutrophils, T-Lymphocytes, Immunoglobulins, Normal values, Immunoglobulin E, T-Lymphocytes, Regulatory, Immunity, medicine, Humans, Distribution (pharmacology), Asthmatic patient, Asthma, biology, Host (biology), business.industry, Complement System Proteins, Middle Aged, medicine.disease, Immunology, biology.protein, Female, Antibody, business
Abstract

The efficiency of some components of the host defense system has been evaluated in 32 atopic patients with rhinitis, asthma or asthma and rhinitis. No alterations in components of complement (C3 and C4), serum immunoglobulins (IgG, IgA, and IgM) and neutrophil functional parameters were found. As expected, serum IgE values were higher than in controls. A decreased percentage of total circulating T lymphocytes, an increased percentage of Ia1-positive cells, but normal values of OKT4- and OKT8-positive T lymphocytes were demonstrated. However, a greater heterogeneity in the distribution of the suppressor-cytotoxic subset was shown in atopic patients.

Published
1986
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