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3. Relationship between clinical and radiological signs of bronchiectasis in COPD patients: Results from COSYCONET

Author

Stefan, Andreas, Robert, Bals, Jürgen, Behr, Kathrin, Kahnert, Burkhard, Bewig, Bahmer, Thomas, Roland, Buhl, Ralf, Ewert, Beate, Stubbe, Joachim H, Ficker, Manfred, Gogol, Christian, Grohé, Rainer, Hauck, Matthias, Held, Berthold, Jany, Markus, Henke, Felix, Herth, Gerd, Höffken, Hugo A, Katus, Anne-Marie, Kirsten, Henrik, Watz, Rembert, Koczulla, Klaus, Kenn, Juliane, Kronsbein, Cornelia, Kropf-Sanchen, Christoph, Lange, Peter, Zabel, Michael, Pfeifer, Winfried J, Randerath, Werner, Seeger, Michael, Studnicka, Christian, Taube, Helmut, Teschler, Hartmut, Timmermann, Christian, Virchow J., Claus, Vogelmeier, Ulrich, Wagner, Tobias, Welte, Hubert, Wirtz, Lehnert, Doris, Struck, Birte, Krabbe, Lenka, Arikan, Barbara, Tobias, Julia, Spangel, Gina, Teng, Julia, Essen, Ruhrlandklinik gGmbH., Pieper, Jeanette, Gleiniger, Margret, Markworth, Britta, Hinz, Zaklina, Hundack-Winter, Petra, Burmann, Ellen, Wons, Katrin, Rieber, Ulrike, Schaufler, Beate, Seibert, Martina, Schwedler, Katrin, Michalewski, Sabine, Rohweder, Sonja, Kiel, Campus, Berger, Patricia, Schottel, Diana, Klöser, Manuel, Janke, Vivien, Untsch, Rosalie, Graf, Jana, Reichel, Anita, Weiß, Gertraud, Traugott, Erich, Ziss, Barbara, Kietzmann, Ilona, Schrade-Illmann, Michaela, Polte, Beate, Böckmann, Cornelia, Hübner, Gudrun, Sterk, Lena, Wirz, Anne, Kahnert, Kathrin, Jörres, Rudolf A., Kauczor, Hans-Ulrich, Biederer, Jürgen, Jobst, Bertram, Alter, Peter, Biertz, Frank, Mertsch, Pontus, Lucke, Tanja, Lutter, Johanna I., Trudzinski, Franziska C., Behr, Jürgen, Bals, Robert, Watz, Henrik, Vogelmeier, Claus F., and Welte, Tobias

Published
2020
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4. CAT score single item analysis in patients with COPD: Results from COSYCONET

Author

Stefan, Andreas, Robert, Bals, Jürgen, Behr, Kathrin, Kahnert, Burkhard, Bewig, Roland, Buhl, Ralf, Ewert, Beate, Stubbe, Ficker, Joachim H., Manfred, Gogol, Christian, Grohé, Rainer, Hauck, Matthias, Held, Berthold, Jany, Markus, Henke, Felix, Herth, Gerd, Höffken, Katus Hugo, A., Anne-Marie, Kirsten, Henrik, Watz, Rembert, Koczulla, Klaus, Kenn, Juliane, Kronsbein, Cornelia, Kropf-Sanchen, Christoph, Lange, Peter, Zabel, Michael, Pfeifer, Randerath Winfried, J., Werner, Seeger, Michael, Studnicka, Christian, Taube, Helmut, Teschler, Hartmut, Timmermann, Christian, Virchow J., Claus, Vogelmeier, Ulrich, Wagner, Tobias, Welte, Hubert, Wirtz, Lehnert, Doris, Struck, Birte, Krabbe, Lenka, Arikan, Barbara, Tobias, Julia, Speth, Kornelia, Pieper, Jeanette, Gleiniger, Margret, Markworth, Britta, Hinz, Zaklina, Burmann, Ellen, Wons, Katrin, Rieber, Ulrike, Schaufler, Beate, Schwedler, Katrin, Michalewski, Sabine, Rohweder, Sonja, Berger, Patricia, Schottel, Diana, Janke, Vivien, Untsch, Rosalie, Graf, Jana, Reichel, Anita, Weiß, Gertraud, Traugott, Erich, Kietzmann, Ilona, Schrade-Illmann, Michaela, Polte, Beate, Hübner, Gudrun, Marietta von Siemens, Sarah, Alter, Peter, Lutter, Johanna I., Kauczor, Hans-Ulrich, Jobst, Bertram, Bals, Robert, Trudzinski, Franziska C., Söhler, Sandra, Behr, Jürgen, Watz, Henrik, Waschki, Benjamin, Bewig, Burkhard, Jones, Paul W., Welte, Tobias, Vogelmeier, Claus F., Jörres, Rudolf A., and Kahnert, Kathrin

Published
2019
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11. Relationship between clinical and radiological signs of bronchiectasis in COPD patients: Results from COSYCONET

Author

Kirsten Anne-Marie, Anne Wirz, Erich Traugott, Ficker Joachim H, Bertram J. Jobst, Vivien Janke, Stubbe Beate, Johanna I. Lutter, Barbara Ziss, Franziska C. Trudzinski, Patricia Berger, Henrik Watz, Gogol Manfred, Thomas Bahmer, Beate Polte, Kronsbein Juliane, Campus Kiel, Lange Christoph, Martina Seibert, Rudolf A. Jörres, Pfeifer Michael, Timmermann Hartmut, Grohé Christian, Tobias Welte, Studnicka Michael, Petra Hundack-Winter, Jana Graf, Jürgen Behr, Diana Schottel, Buhl Roland, Virchow J. Christian, Bewig Burkhard, Ruhrlandklinik gGmbH. Essen, Wirtz Hubert, Rosalie Untsch, Birte Struck, Peter Alter, Kathrin Kahnert, Gudrun Hübner, Vogelmeier Claus, Sabine Michalewski, Kropf-Sanchen Cornelia, Kenn Klaus, Pontus Mertsch, Sonja Rohweder, Hauck Rainer, Andreas Stefan, Ilona Kietzmann, Zabel Peter, Michaela Schrade-Illmann, Höffken Gerd, Julia Tobias, Frank Biertz, Seeger Werner, Manuel Klöser, Kahnert Kathrin, Teschler Helmut, Anita Reichel, Gina Spangel, Ulrike Rieber, Randerath Winfried J, Julia Teng, Tanja Lucke, Herth Felix, Jeanette Pieper, Lenka Krabbe, Taube Christian, Jürgen Biederer, Wagner Ulrich, Doris Lehnert, Claus Vogelmeier, Katrin Schwedler, Henke Markus, Jany Berthold, Katus Hugo A, Bals Robert, Zaklina Hinz, Cornelia Böckmann, Ellen Burmann, Margret Gleiniger, Behr Jürgen, Britta Markworth, Ewert Ralf, Gertraud Weiß, Katrin Wons, Barbara Arikan, Watz Henrik, Beate Schaufler, Lena Sterk, Robert Bals, Hans-Ulrich Kauczor, Koczulla Rembert, Held Matthias, and Welte Tobias

Subjects
Pulmonary and Respiratory Medicine, Male, medicine.medical_specialty, Copd patients, Medizin, Comorbidity, Severity of Illness Index, Pulmonary Disease, Chronic Obstructive, Medicine, Humans, In patient, Lung, Aged, Aged, 80 and over, COPD, Bronchiectasis, business.industry, Phlegm, Middle Aged, medicine.disease, Radiological weapon, Clinical diagnosis, Cohort, Female, Radiography, Thoracic, Radiology, medicine.symptom, business, Tomography, X-Ray Computed
Abstract

Bronchiectasis (BE) might be frequently present in COPD but masked by COPD symptoms. We studied the relationship of clinical signs of bronchiectasis to the presence and extent of its radiological signs in patients of different COPD severity. Visit 4 data (GOLD grades 1-4) of the COSYCONET cohort was used. Chest CT scans were evaluated for bronchiectasis in 6 lobes using a 3-point scale (0: absence, 1: ≤50%, 2: >50% BE-involvement for each lobe). 1176 patients were included (61%male, age 67.3y), among them 38 (3.2%) with reported physicians' diagnosis of bronchiectasis and 76 (6.5%) with alpha1-antitrypsin deficiency (AA1D). CT scans were obtained in 429 patients. Within this group, any signs of bronchiectasis were found in 46.6% of patients, whereby ≤50% BE occurred in 18.6% in ≤2 lobes, in 10.0% in 3-4 lobes, in 15.9% in 5-6 lobes; >50% bronchiectasis in at least 1 lobe was observed in 2.1%. Scores ≥4 correlated with an elevated ratio FRC/RV. The clinical diagnosis of bronchiectasis correlated with phlegm and cough and with radiological scores of at least 3, optimally ≥5. In COPD patients, clinical diagnosis and radiological signs of BE showed only weak correlations. Correlations became significant with increasing BE-severity implying radiological alterations in several lobes. This indicates the importance of reporting both presence and extent of bronchiectasis on CT. Further research is warranted to refine the criteria for CT scoring of bronchiectasis and to determine the relevance of radiologically but not clinically detectible bronchiectasis and their possible implications for therapy in COPD patients.

Published
2020

12. Relationship between clinical and radiological signs of bronchiectasis in COPD patients: Results from COSYCONET

Author

Kahnert, Kathrin, primary, Jörres, Rudolf A., additional, Kauczor, Hans-Ulrich, additional, Biederer, Jürgen, additional, Jobst, Bertram, additional, Alter, Peter, additional, Biertz, Frank, additional, Mertsch, Pontus, additional, Lucke, Tanja, additional, Lutter, Johanna I., additional, Trudzinski, Franziska C., additional, Behr, Jürgen, additional, Bals, Robert, additional, Watz, Henrik, additional, Vogelmeier, Claus F., additional, Welte, Tobias, additional, Stefan, Andreas, additional, Robert, Bals, additional, Jürgen, Behr, additional, Kathrin, Kahnert, additional, Burkhard, Bewig, additional, Bahmer, Thomas, additional, Roland, Buhl, additional, Ralf, Ewert, additional, Beate, Stubbe, additional, Joachim H, Ficker, additional, Manfred, Gogol, additional, Christian, Grohé, additional, Rainer, Hauck, additional, Matthias, Held, additional, Berthold, Jany, additional, Markus, Henke, additional, Felix, Herth, additional, Gerd, Höffken, additional, Hugo A, Katus, additional, Anne-Marie, Kirsten, additional, Henrik, Watz, additional, Rembert, Koczulla, additional, Klaus, Kenn, additional, Juliane, Kronsbein, additional, Cornelia, Kropf-Sanchen, additional, Christoph, Lange, additional, Peter, Zabel, additional, Michael, Pfeifer, additional, Winfried J, Randerath, additional, Werner, Seeger, additional, Michael, Studnicka, additional, Christian, Taube, additional, Helmut, Teschler, additional, Hartmut, Timmermann, additional, Christian, Virchow J., additional, Claus, Vogelmeier, additional, Ulrich, Wagner, additional, Tobias, Welte, additional, Hubert, Wirtz, additional, Lehnert, Doris, additional, Struck, Birte, additional, Krabbe, Lenka, additional, Arikan, Barbara, additional, Tobias, Julia, additional, Spangel, Gina, additional, Teng, Julia, additional, Essen, Ruhrlandklinik gGmbH., additional, Pieper, Jeanette, additional, Gleiniger, Margret, additional, Markworth, Britta, additional, Hinz, Zaklina, additional, Hundack-Winter, Petra, additional, Burmann, Ellen, additional, Wons, Katrin, additional, Rieber, Ulrike, additional, Schaufler, Beate, additional, Seibert, Martina, additional, Schwedler, Katrin, additional, Michalewski, Sabine, additional, Rohweder, Sonja, additional, Kiel, Campus, additional, Berger, Patricia, additional, Schottel, Diana, additional, Klöser, Manuel, additional, Janke, Vivien, additional, Untsch, Rosalie, additional, Graf, Jana, additional, Reichel, Anita, additional, Weiß, Gertraud, additional, Traugott, Erich, additional, Ziss, Barbara, additional, Kietzmann, Ilona, additional, Schrade-Illmann, Michaela, additional, Polte, Beate, additional, Böckmann, Cornelia, additional, Hübner, Gudrun, additional, Sterk, Lena, additional, and Wirz, Anne, additional

Published
2020
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13. CAT score single item analysis in patients with COPD: Results from COSYCONET

Author

Marietta von Siemens, Sarah, primary, Alter, Peter, additional, Lutter, Johanna I., additional, Kauczor, Hans-Ulrich, additional, Jobst, Bertram, additional, Bals, Robert, additional, Trudzinski, Franziska C., additional, Söhler, Sandra, additional, Behr, Jürgen, additional, Watz, Henrik, additional, Waschki, Benjamin, additional, Bewig, Burkhard, additional, Jones, Paul W., additional, Welte, Tobias, additional, Vogelmeier, Claus F., additional, Jörres, Rudolf A., additional, Kahnert, Kathrin, additional, Stefan, Andreas, additional, Robert, Bals, additional, Jürgen, Behr, additional, Kathrin, Kahnert, additional, Burkhard, Bewig, additional, Roland, Buhl, additional, Ralf, Ewert, additional, Beate, Stubbe, additional, Ficker, Joachim H., additional, Manfred, Gogol, additional, Christian, Grohé, additional, Rainer, Hauck, additional, Matthias, Held, additional, Berthold, Jany, additional, Markus, Henke, additional, Felix, Herth, additional, Gerd, Höffken, additional, Katus Hugo, A., additional, Anne-Marie, Kirsten, additional, Henrik, Watz, additional, Rembert, Koczulla, additional, Klaus, Kenn, additional, Juliane, Kronsbein, additional, Cornelia, Kropf-Sanchen, additional, Christoph, Lange, additional, Peter, Zabel, additional, Michael, Pfeifer, additional, Randerath Winfried, J., additional, Werner, Seeger, additional, Michael, Studnicka, additional, Christian, Taube, additional, Helmut, Teschler, additional, Hartmut, Timmermann, additional, Christian, Virchow J., additional, Claus, Vogelmeier, additional, Ulrich, Wagner, additional, Tobias, Welte, additional, Hubert, Wirtz, additional, Lehnert, Doris, additional, Struck, Birte, additional, Krabbe, Lenka, additional, Arikan, Barbara, additional, Tobias, Julia, additional, Speth, Kornelia, additional, Pieper, Jeanette, additional, Gleiniger, Margret, additional, Markworth, Britta, additional, Hinz, Zaklina, additional, Burmann, Ellen, additional, Wons, Katrin, additional, Rieber, Ulrike, additional, Schaufler, Beate, additional, Schwedler, Katrin, additional, Michalewski, Sabine, additional, Rohweder, Sonja, additional, Berger, Patricia, additional, Schottel, Diana, additional, Janke, Vivien, additional, Untsch, Rosalie, additional, Graf, Jana, additional, Reichel, Anita, additional, Weiß, Gertraud, additional, Traugott, Erich, additional, Kietzmann, Ilona, additional, Schrade-Illmann, Michaela, additional, Polte, Beate, additional, and Hübner, Gudrun, additional

Published
2019
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14. Combined effects of lung function, blood gases and kidney function on the exacerbation risk in stable COPD: Results from the COSYCONET cohort

Author

F.C. Trudzinski, K. Kahnert, C.F. Vogelmeier, P. Alter, F. Seiler, S. Fähndrich, H. Watz, T. Welte, T. Speer, S. Zewinger, F. Biertz, H.-U. Kauczor, R.A. Jörres, R. Bals, Andreas Stefan, Bals Robert, Behr Jürgen, Kahnert Kathrin, Bewig Burkhard, Buhl Roland, Ewert Ralf, Stubbe Beate, Ficker Joachim H, Gogol Manfred, Grohé Christian, Hauck Rainer, Held Matthias, Jany Berthold, Henke Markus, Herth Felix, Höffken Gerd, Katus Hugo A, Kirsten Anne-Marie, Watz Henrik, Koczulla Rembert, Kenn Klaus, Kronsbein Juliane, Kropf-Sanchen Cornelia, Lange Christoph, Zabel Peter, Pfeifer Michael, Randerath Winfried J, null eeger Werner, Studnicka Michael, Taube Christian, Teschler Helmut, Timmermann Hartmut, Virchow J. Christian, Vogelmeier Claus, Wagner Ulrich, Welte Tobias, and Wirtz Hubert

Subjects
Pulmonary and Respiratory Medicine, Male, medicine.medical_specialty, Exacerbation, Partial Pressure, Medizin, Renal function, Comorbidity, Acid-Base Imbalance, Kidney Function Tests, Risk Assessment, Cohort Studies, 03 medical and health sciences, Pulmonary Disease, Chronic Obstructive, 0302 clinical medicine, DLCO, Diffusing capacity, Internal medicine, Forced Expiratory Volume, medicine, Humans, Respiratory function, 030212 general & internal medicine, Aged, COPD, Carbon Monoxide, business.industry, Middle Aged, medicine.disease, respiratory tract diseases, Respiratory Function Tests, Cross-Sectional Studies, 030228 respiratory system, Cohort, Cardiology, Disease Progression, Pulmonary Diffusing Capacity, Female, Blood Gas Analysis, Risk assessment, business, Glomerular Filtration Rate
Abstract

Rationale Alterations of acid-base metabolism are an important outcome predictor in acute exacerbations of COPD, whereas sufficient metabolic compensation and adequate renal function are associated with decreased mortality. In stable COPD there is, however, only limited information on the combined role of acid-base balance, blood gases, renal and respiratory function on exacerbation risk grading. Methods We used baseline data of the COPD cohort COSYCONET, applying linear and logistic regression analyses, the results of which were implemented into a comprehensive structural equation model. As most informative parameters it comprised the estimated glomerular filtration rate (eGFR), lung function defined via forced expiratory volume in 1 s (FEV1), intrathoracic gas volume (ITGV) and (diffusing capacity for carbon monoxide (DLCO), moreover arterial oxygen content (CaO2), partial pressure of oxygen (PaCO2), base exess (BE) and exacerbation risk according to GOLD criteria. All measures were adjusted for age, gender, body-mass index, the current smoking status and pack years. Results 1506 patients with stable COPD (GOLD grade 1–4; mean age 64.5 ± 8.1 y; mean FEV1 54 ± 18 %predicted, mean eGFR 82.3 ± 16.9 mL/min/1.73 m2) were included. BE was linked to eGFR, lung function and PaCO2 and played a role as indirect predictor of exacerbation risk via these measures; moreover, eGFR was directly linked to exacerbation risk. These associations remained significant after taking into account medication (diuretics, oral and inhaled corticosteroids), whereby corticosteroids had effects on exacerbation risk and lung function, diuretics on eGFR, BE and lung function. Conclusion Even in stable COPD acid-base metabolism plays a key integrative role in COPD risk assessment despite rather small deviations from normality. It partially mediates the effects of impairments in kidney function, which are also directly linked to exacerbation risk.

Published
2019

15. Exhaled nitric oxide and influencing factors in a random population sample

Author

Karrasch, Stefan, primary, Ernst, Kathrin, additional, Behr, Jürgen, additional, Heinrich, Joachim, additional, Huber, Rudolf M., additional, Nowak, Dennis, additional, Wichmann, H.-Erich, additional, Baumeister, Sebastian E., additional, Meisinger, Christa, additional, Ladwig, Karl-Heinz, additional, Holle, Rolf, additional, Jörres, Rudolf A., additional, and Schulz, Holger, additional

Published
2011
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