1. Pharmacological, but not genetic, alteration of neural Epo modifies the CO
- Author
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Sofien, Laouafa, Anne-Sophie, Perrin-Terrin, Florine, Jeton, Elizabeth, Elliot-Portal, Rose, Tam, Laurence, Bodineau, Nicolas, Voituron, and Jorge, Soliz
- Subjects
Male ,Respiration ,Mice, Transgenic ,Carbon Dioxide ,Mice, Inbred C57BL ,Tissue Culture Techniques ,Animals, Newborn ,Spinal Cord ,Receptors, Erythropoietin ,Animals ,Protons ,Acidosis ,Extracellular Signal-Regulated MAP Kinases ,Erythropoietin ,Proto-Oncogene Proteins c-akt ,Brain Stem - Abstract
Cerebral erythropoietin (Epo) plays a crucial role for respiratory control in newborn rodents. We showed previously that soluble Epo receptor (sEpoR: an Epo antagonist) reduces basal ventilation and hypoxic hyperventilation at postnatal day 10 (P10) and in adult mice. However, at these ages (P10 and adulthood), Epo had no effect on central chemosensitivity. Nevertheless, it is known that the sensitivity to CO
- Published
- 2016