1. Circulating biomarkers of oxidative stress in chronic obstructive pulmonary disease: a systematic review.
- Author
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Zinellu E, Zinellu A, Fois AG, Carru C, and Pirina P
- Subjects
- Animals, Cell-Free Nucleic Acids blood, DNA blood, DNA Damage, Humans, Lipid Peroxidation, Lipid Peroxides blood, Predictive Value of Tests, Prognosis, Protein Carbonylation, Pulmonary Disease, Chronic Obstructive diagnosis, Pulmonary Disease, Chronic Obstructive etiology, Pulmonary Disease, Chronic Obstructive therapy, Reactive Oxygen Species blood, Risk Factors, Smoking adverse effects, Smoking blood, Biomarkers blood, Oxidative Stress, Pulmonary Disease, Chronic Obstructive blood
- Abstract
Chronic obstructive pulmonary disease (COPD) is a progressive condition characterized by airflow limitation associated with an abnormal inflammatory response of the lungs to noxious particles and gases, caused primarily by cigarette smoking. Increased oxidative burden plays an important role in the pathogenesis of COPD. There is a delicate balance between the toxicity of oxidants and the protective function of the intracellular and extracellular antioxidant defense systems, which is critically important for the maintenance of normal pulmonary functions. Several biomarkers of oxidative stress are available and have been evaluated in COPD. In this review, we summarize the main literature findings about circulating oxidative stress biomarkers, grouped according to their method of detection, measured in COPD subjects.
- Published
- 2016
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