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1. HIV integration and T cell death: additional commentary.

Author

Cooper, Arik, García, Mayra, Petrovas, Constantinos, Takuya Yamamoto, Koup, Richard A., and Nabel, Gary J.

Subjects
*HIV infections, *T cells, *CELL death, *LYMPHOCYTES, *PHOSPHORYLATION
Abstract

Estaquier et al. provide commentary on our paper that elucidated the mechanism by which HIV-1 causes cell death in activated CD4 T lymphocytes. We showed that proviral DNA integration triggers DNA-PK dependent death signaling, leading to p53 phosphorylation and cell demise (Cooper A et al. Nature 498:376-379, 2013). They have raised several hypothetical points that we further clarify here. [ABSTRACT FROM AUTHOR]

Published
2013
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