1. OA05-05. Impact of in vivo CD4 binding during HIV-1 Env trimer immunizations of rhesus macaques
- Author
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G. B. Karlsson Hedestam, Robert A. Seder, Karin Loré, Iyadh Douagi, Christopher Sundling, MM Forsell, Richard T. Wyatt, John R. Mascola, and Sijy O'Dell
- Subjects
lcsh:Immunologic diseases. Allergy ,chemistry.chemical_classification ,biology ,business.industry ,viruses ,Immunogenicity ,Wild type ,virus diseases ,Virology ,Vaccination ,Infectious Diseases ,chemistry ,Immunization ,In vivo ,Immunology ,biology.protein ,Oral Presentation ,Medicine ,Binding site ,Antibody ,lcsh:RC581-607 ,business ,Glycoprotein - Abstract
Background We recently reported that immunization with cleavagedefective soluble HIV-1 envelope glycoproteins (Env) trimers in monkeys, but not in rabbits, results in the elicitation of antibodies directed against the co-receptor binding site of gp120. This finding demonstrates that the high affinity interaction between Env and primate CD4 results in an alteration of Env immunogenicity. To further investigate the impact of Env-CD4 in vivo interactions during vaccination, we immunized rhesus macaques with wild type (wt) and CD4 binding defective Env trimers.
- Published
- 2009