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Objectives To describe the methods of the Spanish Registry of patients with idiopathic inflammatory myopathy (IIM) (Myo-Spain), as well as its strengths and limitations. The main objective of the project is to analyse the evolution and clinical management of a cohort of patients with IIM. Methods Observational, longitudinal, ambispective and multicentre study of a cohort of patients with IIM seen in rheumatology units in Spain. All patients with a diagnosis of IMM will be included in the regular follow-up of the participating centres, regardless of age on initiation of the process. Incident cases will be all patients who at the beginning of the study have been diagnosed for less than 12 months and prevalent cases for more than 12 months. The registry will include data from the visit at baseline, one year and two years. Socio-demographic, clinical, analytical variables, complications, comorbidities, association with other rheumatic diseases, hospital admissions, mortality and treatments will be collected. In addition, indices, scales and questionnaires of activity, muscle involvement, damage, disability, and quality of life will be determined. The recruitment period will be 23 months. The purpose is to obtain a cohort of 400 patients with IMM. Conclusions Myo-Spain registry provides the opportunity to develop a cohort of incident and prevalent patients with IMM in Spain. Myo-Spain will be able to assess in detail the clinical characteristics of the disease at different times. The comprehensive information collected during the visits is expected to provide a broad source of data for future analysis.

Resumen El sindrome SAPHO (sinovitis, acne, pustulosis, hiperostosis y osteitis) comprende un conjunto de manifestaciones cutaneo-osteoarticulares. Se han descrito algunas complicaciones graves que pueden aparecer durante la evolucion de la enfermedad, como la trombosis venosa, principalmente en pacientes que desarrollan afectacion inflamatoria grave de la pared toracica anterior. El objetivo de la presente revision fue analizar los casos descritos en la literatura medica relacionados con la presencia de complicaciones tromboticas en pacientes diagnosticados de sindrome SAPHO e intentar establecer los probables factores de riesgo y su posible mecanismo patogenico. Se analizaron 11 articulos publicados de casos clinicos aislados o series de casos, con un total de 144 pacientes, que describen en total 15 casos de trombosis venosa. Se exponen las caracteristicas clinicas de estos pacientes, se evalua si cumplen los criterios de clasificacion ASAS para espondiloatritis axial y periferica, y se resalta la necesidad de realizar un diagnostico y tratamiento precoces.