1. Clinical and laboratory diagnosis of congenital Zika virus syndrome and diaphragmatic unilateral palsy: case report
- Author
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Alex Sandro Rolland Souza, Marli Tenorio Cordeiro, Jucile do Amaral Meneses, Emanuele Honorato, Edward Araujo Júnior, Priscila Mayrelle da Silva Castanha, Bruna Varginha Ramos Caiado, Silvia de Lourdes Loreto Faquini, Orlando Gomes Santos Neto, Juliana Araújo de Carvalho Schettini, Luisa Medeiros de Mello, Ana Catarina Ishigami, and Rafael Dhalia
- Subjects
Microcefalia ,Infecções por arbovirus ,Artrogripose ,Ultrassonografia pré-natal ,Paralisia respiratória ,Gynecology and obstetrics ,RG1-991 - Abstract
Abstract Introduction: several birth defects associated to congenital Zika virus infection have been reported, although the clinical features have not been fully characterized. Description: this is the first case report on unilateral diaphragmatic paralysis diagnosed on a neonate with congenital Zika confirmed by the examination of the amniotic fluid through polymerase chain reaction (ZIKV RT-PCR) and the examination of cerebrospinal fluid by serological test (IgM ZIKV-ELISA) after birth. The main manifestations detected by intrauterine ultrasound were: microcephaly, ventriculomegaly, intracranial calcifications, enlarged cisterna magna, increased amniotic fluid index and fetal akinesia syndrome. The newborn had acute respiratory failure in the first hours of life, requiring mechanical ventila-tion. The X- ray of the chest showed unilateral diaphragmatic paralysis and cardiomegaly. Discussion: diaphragmatic palsy in congenital Zika has not been previously reported, the etiopathogenic mechanisms of this event in congenital Zika virus needs to be elucidated.
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