1. Preparation and characterization of copper nanoparticles of Schisandra chinensis and evaluation of its antiproliferative activity.
- Author
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Tinjacá, Dario A., Almanza, Ovidio A., Delgado, Felix, Morantes, Sandra Johana, Medina, María C., Torres, Paola, and Martinez, Estefanía
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SCHISANDRA chinensis , *COPPER , *NANOPARTICLES , *SCANNING electron microscopy , *CANCER cells - Abstract
Introduction: Schisandra chinensis is a plant species whose fruits have been well known for its multiple pharmacological effects. In the current work, aqueous extract of S. chinensis fruits is used to produce Copper nanoparticles (CuNPs) through green-synthesis method. Physical and biological essays characterized the nanoparticles obtained. Aim: To produce Copper nanoparticles through a greensynthesis method using the aqueous extract of S. chinensis fruits and to characterize this material using spectroscopic methods, including UV-Vis, FTIR (Fourier Transform Infrared Spectra), X-ray diffraction, and SEM (Scanning electron microscopy). Subsequently, the nanoparticulate material is evaluated against three tumor cell lines: A549 human lung cancer cell line (CRM-CCL-185TM), HT29 human colorectal adenocarcinoma cell line (ATCC® HTB-38TM) and MCF7 breast cancer cell line (ATCC® HTB-22TM). Results: Through a green synthesis method, Copper nanoparticles were synthesized from aqueous extract of S. chinensis fruits, demonstrating a spherical morphology with a size close to 26 nanometers by means of spectral methods. Furthermore, results suggest that the S. chinensis reduced CuNPs were able to induce mainly early apoptotic cell death in cancer cells in a concentration-dependent manner. Conclusions: The results proved that S. chinensis fruit aqueous extract could be applied for a greener synthesis of copper nanoparticles with potential anti-proliferative effect. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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