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Introduccion El objetivo de neustro trabajo es analizar la seguridad, tolerabilidad, respuestas y supervivencia en pacientes con linfoma no Hodgkin agresivo administrando ciclofosfamida, doxorrubicina, vincristina y prednisona (CHOP) con intensificacion de dosis.

We detail time trends in the incidence of non-Hodgin’s lymphoma over the period 1980–1894 and analyze prognostic factors in a retrospective study. To that end, 587 patients were diagnosed of non-Hogdkin’s lymphoma from 1980 to 1994. Average annual incidence rate of non-Hodgkin’s lymphoma per 100,000 persons in our study has risen from 5.5 in 1981–1985 to 8.6 in 1991–1994. The incidence rate increased by almost 22% in males, and by 79% in females. In patients 75 years and older the incidence has increased 98%. The largest increases of incidence were observed in extranodal involvement (86%), stage IV (77%) and intermediate grade (53%). Prognostic factors for the overall survival in the multivariate analysis were: histology (p

El objetivo del estudio es el analisis de la supervivencia en el cancer colorrectal metastasico tras la cirugia de rescate. Entre 1991 y 1998 se diagnosticaron 498 pacientes con cancer colorrectal. En 10 pacientes se realizo cirugia de rescate de metastasis metacronicas hepaticas o pulmonares. Se analizaron las caracteristicas clinicas, el tratamiento realizado y la supervivencia. Siete fueron hombres y 3 mujeres con edades comprendidas entre 36–75 anos (mediana: 61 anos). La localizacion mas frecuente fue recto seguida de sigma. Solo 3 pacientes tenian afectacion ganglionar. La localizacion mas frecuente de las metastasis fue hepatica, seguida de pulmonar. El nUmero de metastasis fue 3 en un paciente, 2 en 3 pacientes y en el resto fue Unica. El tamano oscilo entre 2 y 6,5 cm. La mediana del intervalo libre de enfermedad hasta el diagnostico de la metastasis fue de 17 meses (rango: 8–48). El intervalo libre de enfermedad tras metastasectomia fue de 15,5 meses de mediana (rango: 3–72). La mediana del tiempo de seguimiento fue 47 meses (rango: 19–97). La cirugia de rescate de las metastasis hepaticas y pulmonares del cancer colorrectal puede ofrecerun aumento de la supervivencia en pacientes seleccionados. The aim of this research is the analysis of the survival after metastatic colorectal cancer resection. From 1991 to 1998 a total of 498 patients with colorectal cancer were diagnosed. This study reviewed 10 patients who underwent resection of both hepatic and pulmonary metastases from colorectal cancer. The clinical characteristics, the treatment and the survival were analysed. Seven of these patients were men and three women between 36–75 years old (median: 61 years). Rectum followed by sigma was the most frequent location. Only three patients presented nodal afection. The hepatic site was the most frequent, followed by the pulmonary. The number of metastases were three in one patient, two in three patients and one for the rest. The size varied between 2 and 6.5 cm. The median of the disease free interval after metastasectomy was 15.5 months (range: 3–72 months). The median follow-up was 47 months (range: 19–97). Resection of pulmonary and hepatic metastases in colorectal cancer can offer an increase of survival in selected patients.