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Introduction. Spinal Dysraphism is present in nearly 1,500 newborns each year in Mexico. Of these, 95% will show neurogenic urinary bladder, most frequent disease attended at CRIT Estado de Mexico Urology Service. Objective. To evaluate urinary bladder function alteration (urodynamics and cystography), and upper urinary tract deterioration (renal ultrasound and serum creatinine) in children with Spinal Dysraphism Material and methods. Observational, descriptive, retrospective and transversal study. Patients from 5 to 18 years old, with at least one urodynamic study, retrograde cystography, serum creatinine, and renal ultrasound. From January, 2005 to December, 2008. Statistical analysis: Mann-Whitney U Test, Kruskal-Wallis Test and linear association. Results. According to the anatomical level of presentation the patient distribution (n = 97) was lumbar 47% (46), thoracic 39% (38), thoracolumbar 12% (12), and cervical 1% (one). 93% received some form of treatment. Urodynamics showed normal findings in 5%, hyperactive bladder 68% and hypoactive bladder 27%. Hyperactive bladder presented significant lower bladder capacity. 22 patients showed vesicoureteral reflux, 10 of them of high grade (IV/V). 78 (80%) children had a normal renal ultrasound. The median serum creatinine was 0.57 mg/dL (± 0.25 SD). A positive but weak linear association between hydronephrosis and vesicoureteral reflux vs. creatinine level was shown (R2 = 0.051 y R2 = 0.024). Conclusions. A linear positive association between ultrasonographic findings, serum creatinine and vesicoureteral reflux was demonstrated (an increased upper urinary tract deterioration with higher levels of vesicoureteral reflux was observed). There were no associations between renal function deterioration and urodynamic bladder findings. [ABSTRACT FROM AUTHOR]