1. Which route of administration of acid tranexamic, intravenous or intra-articular, is more effective in the control of post-surgical bleeding after a total hip arthroplasty? A prospective, controlled and randomized study.
- Author
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Gómez Barbero P, Gómez Aparicio MS, Blas Dobón JA, Pelayo de Tomás JM, Morales Suárez-Varela M, and Rodrigo Pérez JL
- Subjects
- Administration, Intravenous, Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Injections, Intra-Articular, Male, Middle Aged, Prospective Studies, Young Adult, Antifibrinolytic Agents administration & dosage, Arthroplasty, Replacement, Hip, Postoperative Hemorrhage prevention & control, Tranexamic Acid administration & dosage
- Abstract
Introduction: One of the most frequent complications after a total hip arthroplasty (THA) is bleeding, intravenous tranexamic acid (TXA) is used to reduce it. We considered it necessary to carry out a study to clarify which administration route is superior., Material and Method: Prospective, controlled and randomized study in 2 arms carried out between February 2017 and February 2018. 15mg/kg of intravenous TXA were administered in group-A and 2gr of intra-articular TXA in group-B. The values of haemoglobin and haematocrit were evaluated at 24h-72h, blood loss volume, drained blood volume, transfusions and complications., Results: 78 patients were included, 31 with intravenous treatment and 47 with intra-articular. The decrease of haemoglobin in the intravenous group was 3.15±1.64g/dl in 24h and 3.75±1.56g/dl in 72h, the haematocrit decreased by 10.4±4.17% in 24h and 11.85±4.15% in 72h. In the intra-articular group there was a haemoglobin fall of 3.03±1.30g/dl in 24h and 3.22±1.2g/dl in 72h and the haematocrit fell by 10.66±3.6% and 12,11±3.29% in 24 and 72h (P>.05). The mean drainage in 24h was 195.80ml in group-A versus 253.93ml in group-B (P>.05) and in 48h it was 225.33ml in group-A and 328.19ml in group-B (P=.009). The intravenous group lost an average of 1,505ml of blood compared to the 11,280ml of the intra-articular group. In 5.1% of the cases, transfusions were necessary. We had no secondary complications., Conclusions: The different routes of administration of TXA in THA have a similar effect in the reduction of postoperative bleeding. There was no evidence of an increase in complications., (Publicado por Elsevier España, S.L.U.) more...
- Published
- 2019
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