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O presente protocolo aborda o tratamento da asma grave em crianças acima de seis anos de idade e adolescentes, alinhada à definição do “International European Respiratory Society/American Thoracic Society guidelines on definition, evaluation and treatment of severe asthma” (ERS/ATS) de 2014. Poderá ser utilizado por profissionais da saúde que tratam desses pacientes tais como pediatras, pneumologistas pediátricos e de adultos, clínicos gerais, médicos da atenção primária à saúde, assim como profissionais da enfermagem, fisioterapia, psicologia, nutrição, dentre outros. The present protocol addresses the treatment of severe asthma in children over six years of age and adolescents, in line with the definition of the “International European Respiratory Society/American Thoracic Society guidelines on definition, evaluation and treatment of severe asthma” (ERS/ATS) of 2014. It can be used by health professionals who treat these patients such as pediatricians, pediatric and adult pulmonologists, general practitioners, primary health care physicians, as well as professionals in nursing, physiotherapy, psychology, nutrition, among others.