1. [Clinical and biochemical characterization of isoniazid-induced auto-antibodies]
- Author
-
C de B, Granja, M B, Santiago, V S, Viana, C, Bueno, C A, Kumeda, R M, de Oliveira, and W, Cossermelli
- Subjects
Adult ,Male ,Adolescent ,Blotting, Western ,Enzyme-Linked Immunosorbent Assay ,Middle Aged ,Histones ,Immunoglobulin M ,Antibodies, Antinuclear ,Isoniazid ,Humans ,Tuberculosis ,Female ,Longitudinal Studies ,Child ,Tuberculosis, Pulmonary ,Aged - Abstract
Isoniazid (INH) is one among many drugs capable of inducing autoantibodies and, in some cases, a lupus-like syndrome (LE). A longitudinal study was performed in 24 tuberculosis patients treated with INH to detect antibodies (A-AH) to total histones and fractions. Antinuclear antibodies were observed in two patients after treatment. Higher frequency of IgM-AH was also observed. IgM-AH binding to all fractions were observed in those serum samples exhibiting stronger ELISA reactivity. Conversely, binding to only H1 occurred when lower IgM-AH activity was tested. Correlations with clinical expressions of LE were not observed in the present study.
- Published
- 1990