This article is on the “resistance to change" facing organizations in the West Central Region (WCR), defined here as Knowledge Needs (NC), which hinder their internal performance and eventual development and that of the region, given the conditions that are imposed by the neoliberal process of globalization. These were identified in 60 research papers from the National Reality Seminars which were held at the University of Costa Rica West headquarters for over seven years. The analysis of each project allowed establishing that, of the 8 possible KN, the priority is in knowing: how to eliminate obstacles for efficient work, how to better include and satisfy people´s needs, how to take advantage of abilities and competences for group work, and how to bring forward a unified strategy. It is argued that, in spite of the importance for organizational development, the KN oriented know how to improve the way people identify with the objectives from the organization identified in only one case, and seeking to establish how KN foster new forms of leadership, not found in any of the research projects analyzed. [ABSTRACT FROM AUTHOR]