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Start Over Author "Goldberg, M." Journal revue d'epidemiologie et de sante publique
79 results on '"Goldberg, M."'

21. [Selection effects in epidemiological cohorts: nature, causes and consequences]

Author

Goldberg M and Danièle Luce

Subjects
Adult, Cohort Studies, Odds Ratio, Humans, Longitudinal Studies, Middle Aged, Selection Bias, Aged, Follow-Up Studies, Healthy Worker Effect
Abstract

Selection effects in cohort studies occur when the population observed over time differs from the target population due to the inclusion or follow-up of the subjects. Selection effects may bias the estimation of the frequency of the disease and of the exposure of interest, or the estimation of the association between disease and exposure. In industrial cohorts, where subjects are not volunteers, the reasons why they were hired and they stay working in a company are often linked with lifestyle factors or health problems that can be associated with the diseases or the exposures of interest. This phenomenon is known as the "healthy worker effect". When the cohort includes volunteers, other selection effects associated with the reasons why the individuals participate in the study and stay in the cohort may occur. The time course of both exposure of interest and health status during follow-up may also be associated with the probability of staying in the cohort. We describe the main components of the various selection effects associated with inclusion of the subjects at baseline, with their follow-up during the observation of the cohort, and we examine the main components of the selection effects and their consequences.

Published
2002

22. [Regional differences in the compensation of pleural mesothelioma as occupational disease in France (1986-1993)]

Author

Goldberg M, Goldberg S, and Danièle Luce

Subjects
Male, Mesothelioma, Occupational Diseases, Pleural Neoplasms, Humans, Workers' Compensation, Female, France, Probability
Abstract

Occupational exposure to asbestos is responsible for 80% at least of all mesothelioma in developed countries. In France there are important regional differences in the rate of mesothelioma compensated as occupational diseases, without knowing if these differences could be explained by a real difference of risk. The objective here is to quantify these regional differences in relation with the differences of level of risk.The analysis compares, for each of the 16 regions of the national social security system, mortality for both genders and among men by pleural cancer (ICD 163) in the general population and mesothelioma compensated as occupational diseases during the 1986-1993 period. We computed for each region the number of expected compensated mesothelioma under the hypothesis where the regional distributions of compensated mesothelioma and mesothelioma deaths are the same; as well as the percentage of compensated mesothelioma compared to the deaths, and the variation from the national mean under two hypotheses, high and low; and the probability that a mesothelioma is compensated as an occupational disease taking as a reference the "best" region.The compensation rate differed significantly among regions (p0.05) and for men, the rate between observed and expected numbers of compensated mesothelioma varied from 0.15 (region of Montpellier) to 2.29 (region of Nantes), a ratio over 15. For all of France, the compensation rate was 25% under the best hypothesis. The region of Nantes compensated 61.5% of the male mesothelioma as occupational diseases, while the region of Montpellier and Clermont-Ferrand only around 5%. The probability for a mesothelioma to be compensated, compared to the region of Nantes, was 2.5 times less in national average, and about 10 times less in Montpellier and Clermont-Ferrand regions.In spite of limits linked to the imprecision of the available data, important regional differences in term of compensation of mesothelioma as occupational diseases clearly exist. Indications lead to think that their origin lies essentially in differences between physicians when considering the occupational etiology of mesothelioma, but differences within the system of compensation of occupational diseases can not be excluded. An improvement of the national statistical system concerning occupational diseases is highly recommendable.

Published
1999

26. [Cancer incidence among active male workers at Electricite de France-Gaz de France]

Author

Chevalier A, Goldberg M, Godard C, Guénel P, Callet B, Antonini B, Medard A, and Coing F

Subjects
Adult, Male, Fossil Fuels, Adolescent, Incidence, Middle Aged, Occupational Diseases, Electricity, Socioeconomic Factors, Neoplasms, Population Surveillance, Absenteeism, Humans, France, Longitudinal Studies, Registries
Abstract

The social security department of the French national electric and gas company has established a cancer register among a population of about 150,000 active employees based on sick leaves of both short and long duration as well as deaths recorded along with their medical cause. A first study conducted in male workers, aged 20-59, during the 1978-1989 period showed a lower cancer incidence for almost every site of cancer except for leukaemias and others reticuloses tumors of lymphoid and histiocyte tissues, compared with the French general population (SIR = 148 and 218 resp.). Between the 1978-1982 and 1983-1989 periods, a marked decrease (statistically significant) was observed in the incidence of larynx cancer and cancers of all sites usually related with excessive alcohol consumption. During the same period the incidence of pancreatic cancer has almost doubled. Large variations according to socio-economic status were observed for cancers of the lung, the pharynx, the oral cavity and the oesophagus and, also, to a lesser degree, for tumours of the testis and the bladder and leukaemias. The results suggest further studies of occupational factors. Interest and limits of such a compagny register are discussed.

Published
1996

30. [Potential role of environmental and domestic exposure to tremolite in pleural cancer in New Caledonia]

Author

Goldberg P, Danièle Luce, Ma, Billon-Galland, Quénel P, Salomon-Nekiriai C, Nicolau J, Brochard P, and Goldberg M

Subjects
Male, Air Pollutants, New Caledonia, Asbestos, Amphibole, Construction Materials, Risk Factors, Pleural Neoplasms, Population Surveillance, Housing, Humans, Female, Environmental Exposure, Middle Aged
Abstract

A previous study of respiratory cancers in New Caledonia (1978-1987) showed an excess risk of pleural cancer in this South Pacific French Territory, leading to the identification of an environmental pollution. In some villages, the residents use for their houses a whitewash made from a rock derived from local outcroppings. Analysis of samples of rock and whitewash showed that they consisted of tremolite asbestos. High levels of tremolite were detected in airborne samples collected in these villages and in biological specimens of patients with pulmonary cancer or mesothelioma; the concentrations of fibers are up to 78,000 fibers per litre of air and 44 millions of fibers per gramme of dry tissue. Besides the whitewash, the environmental exposure to tremolite fibers could also be associated with certain occupations. A case control study under process will allow the estimation of respiratory cancer risks associated with the exposure to tremolite.

Published
1995

41. Le Programme national de surveillance du mésothéliome

Author

Gilg Soit Ilg, A., primary, Imbernon, E., additional, Rolland, P., additional, Ducamp, S., additional, Chamming's, S., additional, de Quillacq, A., additional, Frenay, C., additional, Launoy, G., additional, Pairon, J.-C., additional, Astoul, P., additional, Galateau-Sallé, F., additional, Brochard, P., additional, and Goldberg, M., additional

Published
2008
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