10 results on '"Bosello, Silvia"'
Search Results
2. Tumour-associated antigens in systemic sclerosis patients with interstitial lung disease: association with lung involvement and cancer risk.
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De Luca, Giacomo, Bosello, Silvia L., Berardi, Giorgia, Rucco, Manuela, Canestrari, Giovanni, Correra, Miriam, Mirone, Luisa, Forni, Franca, Di Mario, Clara, Danza, Francesco M., Pirronti, Tommaso, and Ferraccioli, Gianfranco
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TUMOR risk factors , *TUMOR markers , *ACADEMIC medical centers , *BLOOD testing , *CONFIDENCE intervals , *ENZYME-linked immunosorbent assay , *INTERSTITIAL lung diseases , *LONGITUDINAL method , *MULTIVARIATE analysis , *PATIENT monitoring , *PUBLIC health surveillance , *PULMONARY function tests , *STATISTICS , *SYSTEMIC scleroderma , *LOGISTIC regression analysis , *DATA analysis , *RELATIVE medical risk , *SEVERITY of illness index , *DATA analysis software , *DESCRIPTIVE statistics , *ODDS ratio , *MANN Whitney U Test , *DISEASE complications , *THERAPEUTICS - Abstract
Objective. To evaluate the serum levels of tumour-associated antigens (TAAs) in patients with SSc and interstitial lung disease (ILD) and to define whether their levels mirror the severity and the progression of lung damage. Methods. Data from 80 SSc patients with ILD were collected at baseline and after 2 years as well as from 40 SSc controls without ILD. The occurrence of any malignancy was recorded. Results. At baseline, an increase of at least one TAA was present in 35 SSc patients with ILD compared with 6 SSc patients without ILD (P< 0.0001); this was associated with lower forced vital capacity (FVC) and higher interstitial and alveolar scores. Levels of carbohydrate antigen 15-3 and carcinoembryonic antigen inversely correlated with FVC and directly correlated with alveolar and interstitial scores and their levels were higher in patients who presented a progression of lung damage after 2 years. During 4 years of follow-up, a malignancy was detected in seven patients who already had an increase of at least one TAA. Values of TAAs increased over time in patients who developed cancer, while their trend remained stable in the others. At multivariate analysis, to have three or more TAAs emerged as a strong independent predictor of the development of malignancies [relative risk 24.1 (95% CI 1.8, 315.0), P = 0.02]. Conclusion. TAAs can be elevated in the sera of SSc patients and correlate with the degree of lung damage, suggesting a role as severity biomarkers. Close follow-up is necessary in SSc patients because of the increased cancer risk overall in patients with increased TAAs. [ABSTRACT FROM AUTHOR]
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- 2015
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3. Comment on: Skin improvement is a surrogate for favourable changes in other organ systems in early diffuse cutaneous systemic sclerosis.
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Bosello, Silvia, Gremese, Elisa, and Ferraccioli, Gianfranco
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BIOMARKERS , *RESPIRATORY measurements , *SKIN care , *SYSTEMIC scleroderma , *DISEASE relapse , *DISEASE progression - Published
- 2020
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4. Significant nailfold capillary loss and late capillaroscopic pattern are associated with pulmonary arterial hypertension in systemic sclerosis.
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Angelis, Rossella De, Riccieri, Valeria, Cipolletta, Edoardo, Papa, Nicoletta Del, Ingegnoli, Francesca, Bosello, Silvia, Spinella, Amelia, Pellegrino, Greta, Pinto, Marco de, Papa, Silvia, Armentaro, Giuseppe, and Giuggioli, Dilia
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PULMONARY hypertension diagnosis , *CAPILLARIES , *CROSS-sectional method , *ANGIOSCOPY , *NAILS (Anatomy) , *DESCRIPTIVE statistics , *CHI-squared test , *ODDS ratio , *SYSTEMIC scleroderma , *CASE-control method , *RESEARCH , *CARDIOVASCULAR system physiology , *CONFIDENCE intervals , *BIOMARKERS , *DISEASE complications - Abstract
Objective To evaluate differences in nailfold videocapillaroscopy (NVC) findings between SSc patients with and without a diagnosis of pulmonary arterial hypertension (PAH). Methods One hundred and ten SSc patients were enrolled in this cross-sectional, case–control, multicentre study. Patients were divided into cases (SSc-PAH confirmed by right heart catheterization) and controls (SSc-nonPAH with low probability of PAH). NVC patterns (early, active and late) and morphological parameters (microvascular density, non-specific abnormalities, giant capillaries, micro-haemorrhages, avascular areas) were considered using a semiquantitative scoring system. Results SSc-PAH patients showed higher frequencies of late pattern (P < 0.01), non-specific abnormalities (P < 0.01), lower capillary density (P < 0.01), higher avascular areas (P < 0.01) and a higher mean NVC score (P < 0.01). Contrarily, the early/active pattern (P < 0.01) and a higher rate of micro-haemorrhages (P = 0.04) were more frequent in non-PAH patients. By a multivariate analysis, SSc-PAH patients, compared with non-PAH, had more non-specific abnormalities [27/55, 49.1% vs 10/55, 18.2%; adjusted odd ratio (OR) 16.89; 95% CI: 3.06, 93.16], a lower capillary density (grade 3, 20/55, 36.4% vs 5/55, 9.1%; adjusted OR 38.33; 95% CI: 2.34, 367.80) and avascular areas (18/55, 32.7% vs 10/55, 18.2%; adjusted OR 16.90; 95% CI: 2.64, 44.35). A correlation was found between the mean pulmonary arterial pressure and avascular areas (P < 0.01), capillary density (P < 0.01) and non-specific abnormalities (P < 0.01). A clinical model including the NVC variables may be able to predict a diagnosis of PAH. Conclusion Our results indicate that the distinctive peripheral microcirculatory injury of SSc, i.e. capillary loss and morphological abnormalities, appear more severe and pronounced in patients with SSc-PAH. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Survival and prognostic factors from a multicentre large cohort of unselected Italian systemic sclerosis patients.
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Cacciapaglia, Fabio, Airò, Paolo, Fornaro, Marco, Trerotoli, Paolo, Lorenzis, Enrico De, Corrado, Addolorata, Lazzaroni, Maria Grazia, Natalello, Gerlando, Montini, Fabio, Altomare, Alberto, Urso, Livio, Verardi, Lucrezia, Bosello, Silvia Laura, Cantatore, Francesco Paolo, and Iannone, Florenzo
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SURVIVAL , *PULMONARY arterial hypertension , *CONFIDENCE intervals , *SYSTEMIC scleroderma , *INTERSTITIAL lung diseases , *DESCRIPTIVE statistics - Abstract
Objectives Survival and death prognostic factors of SSc patients varied during the past decades. We aimed to update the 5- and 10-year survival rates and identify prognostic factors in a multicentre cohort of Italian SSc patients diagnosed after 2009. Material and methods Patients who received a diagnosis of SSc after 1 January 2009 and were longitudinally followed up in four Italian rheumatologic centres were retrospectively assessed up to 31 December 2020. Overall survival of SSc patients was described using the Kaplan–Meier method. Predictors of mortality at 10-year follow-up were assessed by the Cox regression model. A comparison of our cohort with the Italian general population was performed by determining the standardized mortality ratio (SMR). Results A total of 912 patients (91.6% females, 20% dcSSc) were included. Overall survival rates at 5 and 10 years were 94.4% and 89.4%, respectively. The SMR was 0.96 (95% CI 0.81, 1.13), like that expected in the Italian general population. Pulmonary arterial hypertension (PAH) and interstitial lung disease (ILD) associated with pulmonary hypertension (PH) significantly reduced survival (P < 0.0001). Main death predictors were male gender (HR = 2.76), diffuse cutaneous involvement (HR = 3.14), older age at diagnosis (HR = 1.08), PAH (HR = 3.21), ILD-associated PH (HR = 4.11), comorbidities (HR = 3.53) and glucocorticoid treatment (HR= 2.02). Conclusions In the past decade, SSc patients have reached similar mortality of that expected in the Italian general population. Male gender, diffuse cutaneous involvement, comorbidities and PAH with or without ILD represent the main poor prognostic factors. [ABSTRACT FROM AUTHOR]
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- 2023
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6. Lung vascular changes as biomarkers of severity in systemic sclerosis–associated interstitial lung disease.
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Bruni, Cosimo, Occhipinti, Mariaelena, Pienn, Michael, Camiciottoli, Gianna, Bartolucci, Maurizio, Bosello, Silvia Laura, Payer, Christian, Bálint, Zoltán, Larici, Anna Rita, Tottoli, Alessandra, Tofani, Lorenzo, Lorenzis, Enrico De, Lepri, Gemma, Bellando-Randone, Silvia, Spinella, Amelia, Giuggioli, Dilia, Masini, Francesco, Cuomo, Giovanna, Lavorini, Federico, and Colagrande, Stefano
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BIOMARKERS , *DIGITAL image processing , *INTERSTITIAL lung diseases , *SYSTEMIC scleroderma , *RETROSPECTIVE studies , *ACQUISITION of data , *PULMONARY function tests , *MEDICAL records , *DESCRIPTIVE statistics , *RESEARCH funding , *COMPUTED tomography - Abstract
Objectives It has recently become possible to assess lung vascular and parenchymal changes quantitatively in thoracic CT images using automated software tools. We investigated the vessel parameters of patients with SSc, quantified by CT imaging, and correlated them with interstitial lung disease (ILD) features. Methods SSc patients undergoing standard of care pulmonary function testing and CT evaluation were retrospectively evaluated. CT images were analysed for ILD patterns and total pulmonary vascular volume (PVV) extents with Imbio lung texture analysis. Vascular analysis (volumes, numbers and densities of vessels, separating arteries and veins) was performed with an in-house developed software. A threshold of 5% ILD extent was chosen to define the presence of ILD, and commonly used cut-offs of lung function were adopted. Results A total of 79 patients [52 women, 40 ILD, mean age 56.2 (s. d. 14.2) years, total ILD extent 9.5 (10.7)%, PVV/lung volume % 2.8%] were enrolled. Vascular parameters for total and separated PVV significantly correlated with functional parameters and ILD pattern extents. SSc-associated ILD (SSc-ILD) patients presented with an increased number and volume of arterial vessels, in particular those between 2 and 4 mm of diameter, and with a higher density of arteries and veins of <6 mm in diameter. Considering radiological and functional criteria concomitantly, as well as the descriptive trends from the longitudinal evaluations, the normalized PVVs, vessel numbers and densities increased progressively with the increase/worsening of ILD extent and functional impairment. Conclusion In SSc patients CT vessel parameters increase in parallel with ILD extent and functional impairment, and may represent a biomarker of SSc-ILD severity. [ABSTRACT FROM AUTHOR]
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- 2023
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7. Safety and efficacy of rituximab biosimilar (CT-P10) in systemic sclerosis: an Italian multicentre study.
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Campochiaro, Corrado, Luca, Giacomo De, Lazzaroni, Maria Grazia, Zanatta, Elisabetta, Bosello, Silvia Laura, Santis, Maria De, Cariddi, Adriana, Bruni, Cosimo, Selmi, Carlo, Gremese, Elisa, Matucci-Cerinic, Marco, Doria, Andrea, Airò, Paolo, and Dagna, Lorenzo
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C-reactive protein , *IMMUNOSUPPRESSIVE agents , *INTERSTITIAL lung diseases , *MEDICAL cooperation , *NEUTROPENIA , *PATIENT safety , *RESEARCH , *SYSTEMIC scleroderma , *RITUXIMAB , *TREATMENT effectiveness , *BIOSIMILARS - Abstract
Objectives Recent data have shown a significant efficacy of rituximab (RTX) in SSc. An RTX biosimilar (RTX-B) is a more affordable option. We assessed the safety and efficacy of an RTX-B (CT-P10) in SSc. Methods SSc patients treated with RTX-B with at least 6 months of follow-up were retrospectively identified from six Italian referral centres. SSc patients naïve to RTX-B (RTX-Bn) or already treated with RTX originator and switched to an RTX-B (RTX-Bs) were evaluated. A comprehensive assessment of disease characteristics and organ involvement at baseline and after 6 months was obtained. Results Thirty-three SSc patients were selected: 29 (87.9%) females, mean age 51.6 years (s. d. 14.2), mean disease duration 9.8 years (s. d. 8.1); 21 (64.5%) with dcSSc, 20 (60.1%) anti-topoisomerase I, 7 (21.2%) anti-RNA polymerase III and 6 (18.2%) anti-centromere positive. Seventeen (51.5%) were RTX-Bn and 16 were on RTX-Bs (48.5%). RTX was introduced because of skin progression in 18 patients (54.5%), interstitial lung disease (ILD) worsening in 11 (33.3%) and arthritis in 12 (36.4%). All patients were previously treated with immunosuppressants. At RTX-B introduction, 21 (63.6%) patients were on concomitant immunosuppressants: 15 (71.4%) on MMF and 6 (28.6%) on MTX. Twenty-three (69.7%) were on low-dose steroids. After 6 months, a significant reduction of the modified Rodnan skin score (mRSS), 28-joint DAS and CRP was observed (P = 0.002, 0.005 and 0.008, respectively); the mRSS significantly improved both in RTX-Bn (P < 0.024) and RTX-Bs patients (P < 0.031). No significant changes were observed for lung function tests, either in the entire cohort or in the subgroup of ILD patients. Only one RTX-Bs patient experienced transient neutropenia. Conclusion Our data suggest that RTX-B can represent a cheaper option in SSc patients, as it is effective in improving skin and joint involvement and in stabilizing lung function. [ABSTRACT FROM AUTHOR]
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- 2020
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8. Systemic sclerosis myocarditis has unique clinical, histological and prognostic features: a comparative histological analysis.
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Luca, Giacomo De, Campochiaro, Corrado, Santis, Maria De, Sartorelli, Silvia, Peretto, Giovanni, Sala, Simone, Canestrari, Giovanni, Lorenzis, Enrico De, Basso, Cristina, Rizzo, Stefania, Thiene, Gaetano, Palmisano, Anna, Esposito, Antonio, Selmi, Carlo, Gremese, Elisa, Bella, Paolo Della, Dagna, Lorenzo, and Bosello, Silvia Laura
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COMPARATIVE studies , *ECHOCARDIOGRAPHY , *HEART failure , *MAGNETIC resonance imaging , *CARDIOMYOPATHIES , *NONPARAMETRIC statistics , *SYSTEMIC scleroderma , *FIBROSIS , *RETROSPECTIVE studies , *DESCRIPTIVE statistics , *SYMPTOMS - Abstract
Objective To outline the clinical, histological and prognostic features of systemic sclerosis (SSc) endomyocardial biopsy-proven myocarditis with respect to those of diverse endomyocardial biopsy-proven virus-negative myocarditis (VNM). Methods We retrospectively analysed data from three cohorts of endomyocardial biopsy-proven myocarditis: SSc-related VNM (SSc-VNM); isolated VNM (i-VNM); and VNM related to other systemic autoimmune diseases (a-VNM). The degree of myocardial fibrosis was expressed as relative percentage and fibrotic score (0–3). Clinical data, cardiac enzymes, echocardiogram, 24 h ECG Holter and cardiac magnetic resonance were obtained at baseline and during follow-up. Non-parametric tests were used. Results We enrolled 12 SSc-VNM [11 females, mean age 49.3 (14.2) years; seven diffuse-SSc, five early-SSc], 12 i-VNM [12 females, mean age 47.7 (10.8) years] and 10 a-VNM [four females, mean age 48.4 (16.3) years] patients. SSc patients had higher degrees of myocardial fibrosis as assessed by both percentage [SSc-VNM: 44.8 (18.8)%; a-VNM: 28.6 (16.5)%; i-VNM: 24.9 (10.3)%; P = 0.019] and score [SSc-VNM: 2.3 (0.8); a-VNM: 1.4 (1.1); i-VNM: 1.2 (0.7); P = 0.002]. Myocardial fibrosis directly correlated with skin score (r = 0.625, P = 0.03) and number of ventricular ectopic beats on 24 h ECG Holter in SSc patients (r = 0.756, P = 0.01). Dyspnoea class was higher at presentation in SSc-VNM patients (P = 0.041) and we found heart failure only in SSc patients (25%) (P = 0.05). At cardiac magnetic resonance, myocardial oedema was nearly undetectable in SSc-VNM patients compared with others (P = 0.02). All patients received immunosuppressive treatment. The number of patients who died during follow-up due to cardiac complications was significantly higher in SSc-VNM patients (50%), as compared with a-VNM (0%) and i-VNM (8.3%) patients (P = 0.006). Patients who died during follow-up had higher degrees of myocardial fibrosis [52.2 (11.6)% vs 27.5 (12.9)%, P = 0.024; fibrotic score: 2.83 (0.41) vs 1.4 (0.9), P < 0.001]. Conclusion SSc has unique clinical and histological features, as it tends to present more frequently with heart failure and a higher dyspnoea class and to show higher degrees of myocardial fibrosis. These specific features are paralleled by a worse cardiac prognosis. [ABSTRACT FROM AUTHOR]
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- 2020
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9. European multicentre study validates enhanced liver fibrosis test as biomarker of fibrosis in systemic sclerosis.
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Abignano, Giuseppina, Blagojevic, Jelena, Bissell, Lesley-Anne, Dumitru, Raluca B, Eng, Sookhoe, Allanore, Yannick, Avouac, Jerome, Bosello, Silvia, Denton, Christopher P, Distler, Oliver, Ferraccioli, Gianfranco, Jordan, Suzana, Matucci-Cerinic, Marco, Ong, Voon, Messenger, Michael, Hutchinson, Michelle, Buch, Maya H, Emery, Paul, and Galdo, Francesco Del
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CIRRHOSIS of the liver , *SYSTEMIC scleroderma , *RESEARCH , *ALGORITHMS , *BIOMARKERS , *COLLAGEN , *HYALURONIC acid , *LUNGS , *RESEARCH methodology , *MEDICAL cooperation , *MULTIVARIATE analysis , *RESPIRATORY measurements , *SEX distribution , *SYMPTOMS , *SEVERITY of illness index , *DATA analysis software , *MATRIX metalloproteinases , *DIAGNOSIS - Abstract
Objectives To validate enhanced liver fibrosis (ELF) test and its components—amino-terminal propeptide of procollagen type III (PIIINP), tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) and HA—as biomarkers of fibrosis in SSc in an independent, international, multicentre cohort. Methods Two hundred and fifty-four SSc patients from six Rheumatology Centres were included. Sera were collected and stored according to EUSTAR biobanking recommendations and analysed through automated high throughput diagnostics. Statistical analysis was performed with SPSS software. Results Two hundred and forty-seven SSc patients (mean age 55.7 ± 13.9 years, 202 F) were analysed. ELF score, TIMP-1 and PIIINP levels were higher in males (P = 0.0197, P = 0.0107, P = 0.0108 respectively) and in dcSSc (P = 0.001, P = 0.0008, P < 0.0001 respectively). ELF score and the single markers significantly correlated with modified Rodnan skin score (r = 0.37, P < 0.0001), disease activity and severity (P < 0.0001 for all markers, except for HA P = 0.0001) and inversely with forced vital capacity, (FVC) % (TIMP-1, r = −0.21, P = 0.0012; PIIINP, r = −0.26, P = 0.0001), TLC% (ELF score, r = −0.20, P = 0.0036; TIMP-1, r = −0.32, P < 0.0001; PIIINP, r = −0.28, P < 0.0001), diffusion capacity of the lung for carbon monoxide (DLCO) % (P < 0.0001 for all markers, except for HA P = 0.0115). Multivariate analysis indicated that age (P < 0.001), modified Rodnan skin score (P < 0.001) and DLCO% (P = 0.005) were independently associated with ELF score. Conclusion Between the first and this validation studies, the value of the ELF score as independent marker of skin and lung involvement in SSc is confirmed in 457 patients. A longitudinal study is on-going to identify an SSc specific algorithm with predictive value for skin and lung progression. [ABSTRACT FROM AUTHOR]
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- 2019
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10. Residual minimal disease activity in rheumatoid arthritis: a simple definition through an in-depth statistical analysis of the major outcome.
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Pietrapertosa, Donatello, Salaffi, Fausto, Peluso, Giusy, Bosello, Silvia L., Fedele, Anna L., Cuoghi, Ilaria, Michelutti, Alessandro, Gremese, Elisa, and Ferraccioli, Gianfranco F.
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MEDICAL research , *RHEUMATOID arthritis , *MEDICAL statistics , *HEALTH status indicators , *CLINICAL trials - Abstract
Objective. To obtain the simplest definition of minimal disease activity (MDA) and to compare it with published proposed definitions of MDA in patients with RA.Methods. Two hundred and fourteen patients with long-standing RA (LSRA) were evaluated for clinical and laboratory parameters. Factor analysis was performed to remove redundant variables included in the core set measure for MDA definition stated by the OMERACT. Receiver operating characteristic (ROC) curves analysis allowed to obtain optimal cut-off predictors of a 28-joint disease activity score (DAS28) ⩽2.85. These were tested in 112 LSRA and 95 early-onset RA (ERA) patients.Results. Factor and ROC curve analysis showed that the best predictors of a DAS28 ⩽ 2.85 in LSRA cohort were: (i) ESR <20 mm/h (sensitivity: 80%, specificity: 54%); (ii) swollen joint count (out of 28) ⩽2 (sensitivity: 95%, specificity: 74%); (iii) patient global assessment (0–100) ⩽15 (sensitivity: 78%, specificity: 78%); and (iv) HAQ (0–3) ⩽0.5 (sensitivity: 91%, specificity: 61%). To each of these four criteria we assigned a value of 1 when it was satisfied (score ranging: 0–4). The cut-off with the highest overall accuracy for identifying RA patients with DAS28 ⩽ 2.85 was a score ⩾3. We adopted these four parameters in order to define the residual MDA (RMDA). Comparing RMDA criteria, in distinct 112 LSRA and 95 ERA patients, with OMERACT, Simplified Disease Activity Index and Clinical Disease Activity Index definitions of MDA, we found a good agreement in the LSRA cohort and moderate agreement in the ERA cohort.Conclusions. HAQ, PaGA, SJC28 and ESR allow identification of RA patients with an RMDA. The RMDA criteria behaves similarly to OMERACT definitions, but appears more simple and feasible. [ABSTRACT FROM PUBLISHER]
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- 2009
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