6 results on '"Kronbichler, Andreas"'
Search Results
2. Association of venous thromboembolic events with skin, pulmonary and kidney involvement in ANCA-associated vasculitis: a multinational study.
- Author
-
Moiseev, Sergey, Kronbichler, Andreas, Makarov, Egor, Bulanov, Nikolay, Crnogorac, Matija, Direskeneli, Haner, Galesic, Kresimir, Gazel, Ummugulsum, Geetha, Duvuru, Guillevin, Loic, Hrušková, Zdenka, Little, Mark A, Ahmed, Adeel, McAdoo, Stephen P, Mohammad, Aladdin J, Moran, Sarah, Novikov, Pavel, Pusey, Charles D, Rahmattulla, Chinar, and Satrapová, Veronika
- Subjects
- *
THROMBOEMBOLISM risk factors , *SKIN diseases , *RESEARCH , *VEINS , *PULMONARY embolism , *CONFIDENCE intervals , *MULTIPLE regression analysis , *ANTINEUTROPHIL cytoplasmic antibodies , *MEDICAL cooperation , *TERTIARY care , *REGRESSION analysis , *RISK assessment , *KIDNEY diseases , *GRANULOMATOSIS with polyangiitis , *THROMBOEMBOLISM , *DESCRIPTIVE statistics , *STATISTICAL models , *ODDS ratio , *VASCULITIS , *MICROSCOPIC polyangiitis , *DISEASE complications - Abstract
Objective To investigate the occurrence of venous thromboembolic events (VTE) in a large cohort of patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) across the European Union, Turkey, Russia, UK and North America. Methods Patients with a definite diagnosis of AAV who were followed for at least 3 months and had sufficient documentation were included. Data on VTE, including either deep vein thrombosis or pulmonary embolism, were collected retrospectively from tertiary vasculitis centres. Univariate and multivariate regression models were used to estimate odds ratios (ORs) and 95% CIs. Results Over a median follow-up of 63 (interquartile range: 29, 101) months, VTE occurred in 278 (9.7%) of 2869 AAV patients with a similar frequency across different countries (from 6.3% to 13.7%), and AAV subtype [granulomatosis with polyangiitis: 9.8% (95% CI: 8.3, 11.6%); microscopic polyangiitis: 9.6% (95% CI: 7.9, 11.4%); and eosinophilic granulomatosis with polyangiitis: 9.8% (95% CI: 7.0, 13.3%)]. Most VTE (65.6%) were reported in the first-year post-diagnosis. Multiple factor logistic regression analysis adjusted for sex and age showed that skin (OR 1.71, 95% CI: 1.01, 2.92), pulmonary (OR 1.78, 95% CI: 1.04, 3.14) and kidney [eGFR 15–60 ml/min/1.73 m2, OR 2.86 (95% CI: 1.27, 6.47); eGFR <15 ml/min/1.73 m2, OR 6.71 (95% CI: 2.94, 15.33)] involvement were independent variables associated with a higher occurrence of VTE. Conclusion Two-thirds of VTE occurred during the initial phase of active disease. We confirmed previous findings from smaller studies that a decrease in kidney function, skin involvement and pulmonary disease are independently associated with VTE. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
3. Comorbidities in ANCA-associated vasculitis.
- Author
-
Kronbichler, Andreas, Leierer, Johannes, Gauckler, Philipp, and Shin, Jae Il
- Subjects
- *
ATHEROSCLEROSIS risk factors , *CARDIOVASCULAR disease prevention , *DIABETES risk factors , *HYPERTENSION risk factors , *THROMBOEMBOLISM risk factors , *COMORBIDITY , *AUTOIMMUNE diseases , *BLOOD coagulation disorders , *CARDIOVASCULAR diseases risk factors , *DIABETES , *HYPERCHOLESTEREMIA , *HYPERTENSION , *RISK assessment , *VASCULITIS , *DISEASE remission , *ANTINEUTROPHIL cytoplasmic antibodies , *DISEASE complications , *DISEASE risk factors ,THROMBOEMBOLISM prevention ,MORTALITY risk factors - Abstract
The prognosis of patients with ANCA-associated vasculitis has improved over the past decades, but overall survival rates are still unsatisfactory. Recent research has focused on complications of immunosuppressive measures and comorbidities of ANCA-associated vasculitis. This review focuses on thromboembolic and cardiovascular events. A considerably increased risk of thromboembolic events has been reported, which is associated with active disease and impaired coagulation factors. There is mounting evidence that a hypercoagulable state is present even in patients in remission, and studies investigating the impact of tailored anticoagulation are needed to reduce the burden of thromboembolism. Cardiovascular mortality is one of the leading causes of death and accelerated atherosclerosis is frequently observed in patients with ANCA-associated vasculitis. A high frequency of patients develops hypertension, diabetes mellitus and hypercholesterolaemia, either as a consequence of immunosuppression or associated with the underlying disease. The current control of modifiable cardiovascular risk factors is insufficient and thorough reviews should be performed periodically. Treatment of these risk factors should be adopted according to current recommendations related to individual cardiovascular risk prediction. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
4. Clinical associations with venous thromboembolism in anti-neutrophil cytoplasm antibody-associated vasculitides.
- Author
-
Kronbichler, Andreas, Leierer, Johannes, Leierer, Gisela, Mayer, Gert, Casian, Alina, Höglund, Peter, Westman, Kerstin, and Jayne, David
- Subjects
- *
THROMBOEMBOLISM risk factors , *VEIN diseases , *AUTOIMMUNE diseases , *C-reactive protein , *CONFIDENCE intervals , *CREATININE , *EYE , *GASTROINTESTINAL system , *MUCOUS membranes , *MULTIVARIATE analysis , *SKIN , *STATISTICS , *THROMBOEMBOLISM , *TUMORS , *VASCULITIS , *VEINS , *DESCRIPTIVE statistics , *ODDS ratio , *ANTINEUTROPHIL cytoplasmic antibodies , *DISEASE risk factors - Abstract
Objective. To assess potential associations for the development of venous thromboembolic events in patients with ANCA-associated vasculitides (AAV). Methods. Four hundred and seventeen patients enrolled to participate in randomized controlled trials conducted by the European Vasculitis Society were identified. Univariate and multivariate analyses were performed to validate previously proposed and identify novel risks associated with venous thromboembol-ism (VTE) in AAV. Results. VTE occurred in 41 of 417 (9.8%) patients. Uncorrected univariate analysis identified BVAS (odds ratio, OR = 1.05, 95% CI: 1.01, 1.10; P = 0.013), subsequent development of malignancy (OR = 2.6, 95% CI: 1.19, 5.71; P = 0.017), mucous membrane or eye involvement (OR = 2.13, 95% CI: 1.10, 4.11; P = 0.024) and baseline creatinine (OR = 1.08, 95% CI: 0.99, 1.18; P = 0.037) as being associated with the development of VTE. Multivariate analysis highlighted CRP (per 10mg/l increase, OR = 1.05, 95% CI: 1.01, 1.09; P = 0.025), cutaneous involvement (OR = 4.83, 95% CI: 1.63, 14.38; P = 0.005) and gastrointestinal involvement (OR = 6.27, 95% CI: 1.34, 29.37; P = 0.02) among the BVAS items as well as baseline creatinine (per 100 mmol/l increase, OR = 1.17, 95% CI: 1.02, 1.35; P = 0.029) as being associated with VTEs. Conclusion. Our results highlight a role of CRP, baseline creatinine, and cutaneous and gastrointestinal involvement in the risk stratification as being associated with thromboembolic events. Moreover, there might be an association between VTEs and subsequent development of malignancy and disease activity in general. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
5. Nasal carriage of Staphylococcus pseudintermedius in patients with granulomatosis with polyangiitis.
- Author
-
Kronbichler, Andreas, Blane, Beth, Holmes, Mark A, Wagner, Josef, Parkhill, Julian, Peacock, Sharon J, Jayne, David R W, and Harrison, Ewan M
- Subjects
- *
GRANULOMATOSIS with polyangiitis diagnosis , *BACTERIAL growth , *CULTURE media (Biology) , *GENETIC polymorphisms , *GENOMES , *IMMUNOSUPPRESSION , *MASS spectrometry , *MICROBIOLOGICAL techniques , *NASAL cavity , *STAPHYLOCOCCUS , *GRANULOMATOSIS with polyangiitis , *SEQUENCE analysis , *INFECTIOUS disease transmission , *GENETICS - Abstract
The article presents a study which examined the bacterial species that colonize the noses of patients with granulomatosis with polyangiitis (GPA), formerly Wegener's granulomatosis. Also cited are the bacterium Staphylococcus aureus as independent risk factor for GPA relapse, and the detection of Staphylococcus pseudintermedius in the study.
- Published
- 2019
- Full Text
- View/download PDF
6. Extending the spectrum of a chameleon: IgG4-related disease appearing as interstitial nephritis and mimicking anti-neutrophil cytoplasmic antibodyassociated vasculitis.
- Author
-
Kronbichler, Andreas, Gut, Nadezda, Zwerina, Jochen, Neuwirt, Hannes, Rudnicki, Michael, and Mayer, Gert
- Subjects
- *
AUTOIMMUNE disease diagnosis , *AUTOANTIBODIES , *BIOPSY , *BLOOD testing , *DIFFERENTIAL diagnosis , *IMMUNOGLOBULINS , *POSITRON emission tomography , *INTERSTITIAL nephritis , *GRANULOMATOSIS with polyangiitis , *DIAGNOSIS - Abstract
The article discusses the case of a 54 year old female patient of Caucasian descent presented with a past medical history including Hashimoto thyroiditis diagnosed in 2006. Further investigations were initiated including ENT, ophthamological and neurological assessments due to a suspected diagnosis of granulomatosis with polyangiitis. The case is the first description of an IgG4-related tubulointerstitiial nephritis with concomitant positivity of cytoplasmic ANCA and PR3.
- Published
- 2015
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.