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1. The clinical outcomes and healthcare resource utilization in IgG4-related disease: a claims-based analysis of commercially insured adults in the United States.

Author

Wallace, Zachary S, Miles, Gandarvaka, Smolkina, Ekaterina, Petruski-Ivleva, Natalia, Madziva, Duane, Guzzo, Krishan, Cook, Claire, Fu, Xiaoqing, Zhang, Yuqing, Stone, John H, and Choi, Hyon K

Subjects
MEDICAL care use, DRUG toxicity, RESEARCH funding, IMMUNOGLOBULIN G, HEALTH insurance, SEX distribution, HOSPITAL care, TREATMENT effectiveness, AGE distribution, DESCRIPTIVE statistics, RETROSPECTIVE studies, LONGITUDINAL method, CHRONIC diseases, AUTOIMMUNE diseases, MEDICAL appointments, CONFIDENCE intervals, INSURANCE companies, COMORBIDITY, MEDICAL care costs, GLUCOCORTICOIDS, ALGORITHMS, ECONOMIC aspects of diseases
Abstract

Objectives IgG4-related disease (IgG4-RD) can affect nearly any organ and is often treated with glucocorticoids, which contribute to organ damage and toxicity. Comorbidities and healthcare utilization in IgG4-RD are poorly understood. Methods We conducted a cohort study using claims data from a US managed care organization. Incident IgG4-RD cases were identified using a validated algorithm; general population comparators were matched by age, sex, race/ethnicity and index date. The frequency of 21 expert-defined clinical outcomes associated with IgG4-RD or its treatment and healthcare-associated visits and costs were assessed 12 months before and 36 months after the index date (date of earliest IgG4-RD-related claim). Results There were 524 cases and 5240 comparators. Most cases received glucocorticoids prior to (64.0%) and after (85.1%) the index date. Nearly all outcomes, many being common glucocorticoid toxicities, occurred more frequently in cases vs comparators. During follow-up, the largest differences between cases and comparators were seen for gastroesophageal reflux disease (prevalence difference: +31.2%, P  < 0.001), infections (+17.3%, P  < 0.001), hypertension (+15.5%, P  < 0.01) and diabetes mellitus (+15.0%, P  < 0.001). The difference in malignancy increased during follow-up from +8.8% to +12.5% (P  < 0.001). Some 17.4% of cases used pancreatic enzyme replacement therapy during follow-up. Over follow-up, cases were more often hospitalized (57.3% vs 17.2%, P  < 0.01) and/or had an emergency room visit (72.0% vs 36.7%, P  < 0.01); all costs were greater in cases than comparators. Conclusions Patients with IgG4-RD are disproportionately affected by adverse outcomes, some of which may be preventable or modifiable with vigilant clinician monitoring. Glucocorticoid-sparing treatments may improve these outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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2. New-onset versus relapsing giant cell arteritis treated with tocilizumab: 3-year results from a randomized controlled trial and extension

Author

Stone, John H, primary, Spotswood, Helen, additional, Unizony, Sebastian H, additional, Aringer, Martin, additional, Blockmans, Daniel , additional, Brouwer, Elisabeth, additional, Cid, Maria C, additional, Dasgupta, Bhaskar, additional, Rech, Juergen, additional, Salvarani, Carlo, additional, Spiera, Robert, additional, and Bao, Min, additional

Published
2021
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4. Contributors

Author

Abdellatif, Engy, primary, Abeles, Aryeh M., additional, Abelson, Abby G., additional, Abhishek, Abhishek, additional, Abramson, Steven B., additional, Adachi, Jonathan D., additional, Adams, Michael A., additional, Aigner, Thomas, additional, Akira, Shizuo, additional, Aletaha, Daniel, additional, Aliprantis, Antonios O., additional, Almeida de Jesus, Adriana, additional, Altman, Roy D., additional, Amigo, Mary-Carmen, additional, Aringer, Martin, additional, Ascherman, Dana P., additional, Assassi, Shervin, additional, Atamas, Sergei P., additional, Azevedo, Pedro Ming, additional, Baer, Alan N., additional, Baeten, Dominique, additional, Baines, Colin, additional, Baker, Nancy A., additional, Balogh, Emese, additional, Balsa, Alejandro, additional, Baraliakos, Xenofon, additional, Bardin, Thomas, additional, Barnsley, Les, additional, Bathon, Joan M., additional, Bauch, Angela, additional, Belch, Jill J.F., additional, Bellamy, Nicholas, additional, Bellido, Teresita, additional, Benjamin, Michael, additional, Beresford, Michael W., additional, Berman, Brian, additional, Bermas, Bonnie Lee, additional, Bertsias, George, additional, Bilezikian, John P., additional, Bilginer, Yelda, additional, Birnbaum, Julius, additional, Bishop, Felicity L., additional, Bleasel, Jane F., additional, Böhm, Markus, additional, Bolster, Marcy B., additional, Bombardieri, Stefano, additional, Bonelli, Michael, additional, Bonnick, Sydney L., additional, Boumpas, Dimitrios T., additional, Bozec, Aline, additional, Brasington, Richard D., additional, Braun, Juergen, additional, Brown, Matthew A., additional, Bruce, Ian N., additional, Bugbee, William D., additional, Bukhari, Marwan A.S., additional, Burgos-Vargas, Rubén, additional, Burmester, Gerd-Rüdiger, additional, Burns, Jane C., additional, Burr, David B., additional, Buttgereit, Frank, additional, Bykerk, Vivian P., additional, Calabrese, Leonard H., additional, Callen, Jeffrey P., additional, Cavallo, Sabrina, additional, Cawston, Tim E., additional, Chandran, Vinod, additional, Chard, Michael Denis, additional, Chaudhary, Prateek, additional, Chen, Lan X., additional, Choi, Hyon K., additional, Choy, Ernest H., additional, Christopher-Stine, Lisa, additional, Chu, Alvina D., additional, Clauw, Daniel J., additional, Clements, Philip J., additional, Clowse, Megan E.B., additional, Coghlan, J. Gerry, additional, Conaghan, Philip G., additional, Cooper, Cyrus, additional, Costenbader, Karen H., additional, Creamer, Paul, additional, Crispín, José C., additional, Cronstein, Bruce N., additional, Cross, Raymond, additional, Cusano, Natalie E., additional, Cutolo, Maurizio, additional, D'Adamo, Chris, additional, D'Agati, Vivette, additional, D'Cruz, David P., additional, Dagfinrud, Hanne, additional, Daikh, David I., additional, Dalbeth, Nicola, additional, Dalton, Seamus E., additional, Dass, Shouvik, additional, Davis, Aileen M., additional, De Ceulaer, Karel, additional, Deal, Chad L., additional, Deane, Kevin D., additional, Della Rossa, Alessandra, additional, Dellaripa, Paul F., additional, Dennison, Elaine, additional, Denton, Christopher P., additional, Dieppe, Paul, additional, Doherty, Michael, additional, Dolan, Patricia, additional, Donn, Rachelle, additional, Dvorkina, Olga, additional, Dyer, George S.M., additional, Eastell, Richard, additional, Edwards, N. Lawrence, additional, Emery, Paul, additional, Erturan, Gurhan, additional, Espinoza, Luis R., additional, Eyre, Steve, additional, Fanouriakis, Antonios C., additional, Farber, Joshua, additional, Farrokhi, Shawn, additional, Fasth, Anders, additional, Feist, Eugen, additional, Feldman, Debbie, additional, Felson, David T., additional, Fisk, John D., additional, Fitzgerald, G. Kelley, additional, Flores, Raymond H., additional, Fox, David A., additional, Francomano, Clair A., additional, Frangos, Jennifer, additional, Freemont, Anthony J., additional, Fricka, Kevin B., additional, Furst, Daniel E., additional, Gabay, Cem, additional, Gadina, Massimo, additional, Gaston, J.S. Hill, additional, Gay, Steffen, additional, Gensler, Lianne S., additional, Geraldino-Pardilla, Laura, additional, Gerlag, Danielle M., additional, Ginzler, Ellen M., additional, Gizinski, Alison M., additional, Gladman, Dafna D., additional, Gold, Garry E., additional, Goldbach-Mansky, Raphaela, additional, Goldingay, Sarah, additional, Gordon, Sharon M., additional, Gorodkin, Rachel, additional, Goronzy, Jörg J., additional, Görtz, Simon, additional, Grahame, Rodney, additional, Grainger, Andrew J., additional, Gravallese, Ellen M., additional, Greenberg, Jeffrey D., additional, Gujar, Bansari, additional, Hagan, Matilda, additional, Hagley, Karlene, additional, Hakim, Alan J., additional, Hall, John C., additional, Hamuryudan, Vedat, additional, Hanly, John G., additional, Hanson, Eric P., additional, Haraoui, Boulos, additional, Harley, John B., additional, Hashkes, Philip J., additional, Hawker, Gillian A., additional, Hawkins, Philip N., additional, Heiberg, Turid, additional, Heinegård, Dick, additional, Helfgott, Simon M., additional, Ho, Pauline Y.P., additional, Hochberg, Marc C., additional, Hochman, Jacqueline, additional, Hodgkiss-Harlow, Chelsea J., additional, Hoffman, Robert W., additional, Hoffmann, Markus, additional, Holers, V. Michael, additional, Holick, Michael F., additional, Holroyd, Christopher, additional, Hübscher, Osvaldo, additional, Hunter, David J., additional, Husni, M. Elaine, additional, Inman, Robert D., additional, Isaac, Zacharia, additional, Iversen, Maura D., additional, Jabs, Douglas A., additional, Jackson, William, additional, Jaimungal, Sarada, additional, James, Judith A., additional, Javier, Rose-Marie, additional, Johnsen, Alyssa K., additional, Jordan, Joanne M., additional, Kaisho, Tsuneyasu, additional, Kallenberg, Cees G.M., additional, Kane, David, additional, Kapoor, Mohit, additional, Karlson, Elizabeth W., additional, Kassimos, Dimitrios G., additional, Kastner, Daniel L., additional, Katz, Jeffrey N., additional, Kay, Jonathan, additional, Kelly, Jennifer A., additional, Keystone, Edward, additional, Khamashta, Munther A., additional, Khanna, Dinesh, additional, Kjeken, Ingvild, additional, Koch, Alisa E., additional, Koff, Matthew F., additional, Kottyan, Leah, additional, Koutsogeorgopoulou, Loukia A., additional, Kraus, Virginia Byers, additional, Kumar, Pradeep, additional, Kvien, Tore K., additional, Lafyatis, Robert, additional, Landewé, Robert B.M., additional, Langford, Carol A., additional, Lau, Arthur N., additional, Laxer, Ronald M., additional, Learch, Thomas J., additional, Lewith, George, additional, Li, Yi, additional, Liao, Katherine P., additional, Littlejohn, Geoffrey, additional, Lorenzo, Pilar, additional, Luger, Thomas A., additional, Lundberg, Ingrid E., additional, Lundberg, Karin, additional, Machold, Klaus P., additional, MacKenzie, C. Ronald, additional, Mahr, Alfred D., additional, Manheimer, Eric, additional, Marini, Joan C., additional, Marquez, Javier, additional, Marsden, Debbie, additional, Martel-Pelletier, Johanne, additional, Martín-Mola, Emilio, additional, Martínez-Lavín, Manuel, additional, Massarotti, Elena M., additional, Matteson, Eric L., additional, Matzat, Stephen J., additional, Mayahi, Reza, additional, Mayes, Maureen Davidica, additional, McAlindon, Timothy, additional, McBain, Hayley, additional, McCarberg, Bill, additional, McCarthy, Edward F., additional, McCarthy, Geraldine, additional, McDermott, Michael F., additional, McGonagle, Dennis, additional, McLean, Lachy, additional, Merkel, Peter A., additional, Mikdashi, Jamal A., additional, Miller, Frederick W., additional, Miller, Paul D., additional, Minden, Kirsten, additional, Monach, Paul A., additional, Mulligan, Kathleen, additional, Namur, Gauthier, additional, Naredo, Esperanza, additional, Naylor, Kim E., additional, Nelson, Amanda E., additional, Newman, Stanton P., additional, Nordal, Ellen, additional, Nöth, Ulrich, additional, Ntatsaki, Eleana, additional, O'Shea, John J., additional, Oddis, Chester V., additional, Olivé, Alejandro, additional, Omair, Mohammed A., additional, Ombrello, Michael J., additional, Omisade, Antonina, additional, Ong, Voon H., additional, Önnerfjord, Patrik, additional, Orcel, Philippe, additional, Ospelt, Caroline, additional, Ozen, Seza, additional, Paget, Stephen A., additional, Patel, Dipak R., additional, Patrono, Carlo, additional, Pelletier, Jean-Pierre, additional, Pereira, Rosa Maria Rodrigues, additional, Pilkington, Clarissa A., additional, Pillinger, Michael H., additional, Pineda, Carlos, additional, Plenge, Robert M., additional, Price, Andrew, additional, Pricop, Luminita, additional, Rackwitz, Lars, additional, Ravelli, Angelo, additional, Redmond, Anthony C., additional, Reeves, Westley H., additional, Remmers, Elaine F., additional, Requena, Luis, additional, Ribbens, Clio, additional, Richardson, Bruce C., additional, Riera Alonso, Elena, additional, Riley, Graham, additional, Ritchlin, Christopher, additional, Ritter, Susan Y., additional, Rosas, Ivan O., additional, Rowan, Drew D., additional, Rudwaleit, Martin, additional, Rull, Marina, additional, Rygg, Marite, additional, Saag, Kenneth G., additional, Salmon, Jane E., additional, Salter, Donald M., additional, Salzberg, Daniel J., additional, Sambrook, Philip N., additional, Saxne, Tore, additional, Schaible, Hans-Georg, additional, Scher, Jose U., additional, Schett, Georg, additional, Schmitz, Nicole, additional, Schreiber, Benjamin, additional, Schumacher, H. Ralph, additional, Schwartz, Daniella Muallem, additional, Scott, David G.I., additional, Seton, Margaret, additional, Shapiro, Lauren M., additional, Sharby, Nancy, additional, Siegel, Jeffrey, additional, Siegel, Richard M., additional, Sieper, Joachim, additional, Silver, Richard M., additional, Silverberg, Shonni J., additional, Simard, Julia F., additional, Simmons, Barry P., additional, Simms, Robert W., additional, Singer, Nora G., additional, Smith, Malcolm D., additional, Smith, Stacy E., additional, Smolen, Josef S., additional, Spector, Tim D., additional, Steen, Virginia D., additional, Steere, Allen C., additional, Steiner, Günter, additional, Steinert, Andre F., additional, Stojan, George, additional, Stone, John H., additional, Strand, Vibeke, additional, Straub, Rainer H., additional, Streeten, Elizabeth A., additional, Superti-Furga, Giulio, additional, Symmons, Deborah P.M., additional, Szekanecz, Zoltan, additional, Tak, Paul P., additional, Tavoni, Antonio, additional, Taylor, Peter C., additional, Terkeltaub, Robert, additional, Thomas, Sarah S., additional, Thorne, Jennifer E., additional, Tobias, Jonathan H., additional, Tremoulet, Adriana H., additional, Tsokos, George C., additional, Tuan, Rocky S., additional, Turesson, Carl, additional, Unizony, Sebastian H., additional, Valdes, Ana M., additional, van den Berg, Wim B., additional, van der Heijde, Désirée, additional, van Vollenhoven, Ronald Frits, additional, Varga, John, additional, Vassilopoulos, Dimitrios, additional, Vital, Edward M., additional, Walker-Bone, Karen, additional, Wallace, Daniel J., additional, Warburton, Gary, additional, Ward, Robert J., additional, Watts, Richard, additional, Wechalekar, Mihir D., additional, Wedderburn, Lucy R., additional, Weinblatt, Michael E., additional, Weir, Matthew R., additional, Wenham, Claire Y.J., additional, West, Sterling G., additional, Weyand, Cornelia M., additional, White, Kenneth E., additional, Winthrop, Kevin L., additional, Wong, John B., additional, Woolf, Anthony D., additional, Worthington, Jane, additional, Xu, Huji, additional, Yazici, Hasan, additional, Young, D.A., additional, Yurdakul, Sebahattin, additional, Zhang, Yuqing, additional, and Zhuang, Haoyang, additional

Published
2015
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7. New-onset versus relapsing giant cell arteritis treated with tocilizumab: 3-year results from a randomized controlled trial and extension.

Author

Stone, John H, Spotswood, Helen, Unizony, Sebastian H, Aringer, Martin, Blockmans, Daniel, Brouwer, Elisabeth, Cid, Maria C, Dasgupta, Bhaskar, Rech, Juergen, Salvarani, Carlo, Spiera, Robert, and Bao, Min

Subjects
*THERAPEUTIC use of monoclonal antibodies, *GLUCOCORTICOIDS, *CONFIDENCE intervals, *INFLAMMATION, *GIANT cell arteritis, *DISEASE relapse, *RANDOMIZED controlled trials, *DESCRIPTIVE statistics
Abstract

Objective Tocilizumab plus prednisone induces sustained glucocorticoid-free remission in patients with GCA. However, its long-term benefits in new-onset vs relapsing disease are uncertain, and the value of weekly vs every-other-week dosing has not been evaluated. Methods In Giant-Cell Arteritis Actemra (GiACTA) part 1, patients with new-onset or relapsing GCA received blinded tocilizumab weekly (TCZ QW), tocilizumab every-other-week (TCZ Q2W) or placebo for 52 weeks, with a prednisone taper. In part 2 (open-label), patients were treated at investigator discretion for 104 weeks. In this analysis, patients were evaluated according to their original treatment assignments, and outcomes beyond 52 weeks were assessed. Outcomes of interest included time to first flare and cumulative glucocorticoid exposure over 3 years according to baseline disease status. Results Part 1 enrolled 250 patients; 215 entered part 2. At baseline, 48% had new-onset disease and 52% had relapsing disease. In patients with new-onset and relapsing disease, the median time to first flare in the TCZ QW group was 577 and 575 days, respectively, vs 479 and 428 days with TCZ Q2W and 179 and 224 days with placebo; the median cumulative glucocorticoid dose was 3068 mg and 2191 mg with TCZ QW, 4080 mg and 2353 mg with TCZ Q2W, and 4639 mg and 6178 mg with placebo. Conclusion TCZ QW delayed the time to flare and reduced the cumulative glucocorticoid dose in patients with relapsing GCA and new-onset GCA. These data support initiating TCZ QW as part of first-line therapy in all patients with active GCA. Trial registration ClinicalTrials.gov, https://clinicaltrials.gov , NCT01791153. [ABSTRACT FROM AUTHOR]

Published
2022
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9. Mer tyrosine kinase as a possible link between resolution of inflammation and tissue fibrosis in IgG4-related disease

Author

Rovati, Lucrezia, primary, Kaneko, Naoki, additional, Pedica, Federica, additional, Monno, Antonella, additional, Maehara, Takashi, additional, Perugino, Cory, additional, Lanzillotta, Marco, additional, Pecetta, Simone, additional, Stone, John H, additional, Doglioni, Claudio, additional, Manfredi, Angelo A, additional, Pillai, Shiv, additional, and Della-Torre, Emanuel, additional

Published
2021
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12. Contributors

Author

Abeles, Aryeh M., primary, Abelson, Abby G., additional, Abhishek, Abhishek, additional, Abramson, Steven B., additional, Adams, Michael A., additional, Adlam, David M., additional, Aigner, Thomas, additional, Akira, Shizuo, additional, Aksentijevich, Ivona, additional, Aletaha, Daniel, additional, Aliprantis, Antonios O., additional, Allaart, Cornelia F., additional, Allen, Pamela G., additional, Altman, Roy D., additional, Aringer, Martin, additional, Ascherman, Dana P., additional, Assassi, Shervin, additional, Atamas, Sergei P., additional, Baer, Alan N., additional, Baeten, Dominique, additional, Baker, Nancy, additional, Balsa, Alejandro, additional, Barnsley, Les, additional, Bathon, Joan M., additional, Becker, Michael A., additional, Belch, Jill JF, additional, Bellamy, Nicholas, additional, Bellido, Teresita, additional, Benitez, R. Michael, additional, Benjamin, Michael, additional, Beresford, Michael W., additional, Berman, Brian M., additional, Bermas, Bonnie Lee, additional, Bertsias, George, additional, Bilezikian, John P., additional, Blazar, Philip E., additional, Bleasel, Jane F., additional, Böhm, Markus, additional, Boileau, Christelle, additional, Bolster, Marcy B., additional, Bombardieri, Stefano, additional, Bonnick, Sydney, additional, Boumpas, Dimitrios T., additional, Brasington, Richard D., additional, Breedveld, Ferdinand, additional, Brien, Earl W., additional, Brower, Anne C., additional, Brown, Matthew A., additional, Bruce, Ian N., additional, Bugbee, William D., additional, Bukhari, Marwan A.S., additional, Burgos-Vargas, Rubén, additional, Burns, Jane C., additional, Burr, David B., additional, Cagnoli, Patricia C., additional, Calabrese, Leonard H., additional, Callen, Jeffrey P., additional, Canoso, Juan J., additional, Cavallo, Sabrina, additional, Cawston, Tim E., additional, Chard, Michael Denis, additional, Chen, Lan X., additional, Choy, Ernest H.S., additional, Clauw, Daniel J., additional, Clements, Philip J., additional, Colburn, Nona T., additional, Coleman, Laura A., additional, Conaghan, Philip G., additional, Cooper, Cyrus, additional, Cosman, Felicia, additional, Costenbader, Karen H., additional, Creamer, Paul, additional, Crispin, José C., additional, Criswell, Lindsey A., additional, Cronstein, Bruce N., additional, Cross, Raymond, additional, Cusano, Natalie E., additional, Cush, John J., additional, Cutolo, Maurizio, additional, D’Agati, Vivette, additional, Dagfinrud, Hanne, additional, Daikh, David I., additional, Dalton, Seamus E., additional, Dass, Shouvik, additional, David, Jean-Pierre, additional, Davis, Aileen, additional, Deal, Chad L., additional, De Ceulaer, Karel, additional, Deighton, Chris, additional, Dellaripa, Paul F., additional, Rossa, Alessandra Della, additional, Dempster, David, additional, Dennison, Elaine, additional, Denton, Christopher P., additional, Denton, John, additional, Dhawale, Roshan, additional, Doherty, Michael, additional, Dolan, Patricia, additional, Donn, Rachelle, additional, Dooley, Mary Anne, additional, Dougados, Maxime, additional, Drummond, Michael F., additional, Dyer, George S.M., additional, Earp, Brandon E., additional, Edwards, N. Lawrence, additional, Ellender, Patrick, additional, Emery, Paul, additional, Espinoza, Luis R., additional, Farber, Joshua M., additional, Fasth, Anders, additional, Feldman, Debbie, additional, Felson, David T., additional, Fitzgerald, G. Kelley, additional, Flores, Raymond H., additional, Fox, David A., additional, Francomano, Clair A., additional, Freemont, Anthony J., additional, Fresko, Izzet, additional, Fricka, Kevin B., additional, Furst, Daniel E., additional, Gabay, Cem, additional, Gabriel, Sherine E., additional, Galarraga, Bernat, additional, Gäre, Boel Andersson, additional, Garnero, Patrick, additional, Gensler, Lianne S., additional, Gerlag, Danielle M., additional, Geusens, Piet P., additional, Giles, Jon T., additional, Ginzler, Ellen M., additional, Gizinski, Alison M., additional, Gold, Garry, additional, Gonzalez-Rivera, Tania, additional, Gordon, Caroline, additional, Gorodkin, Rachel, additional, Goronzy, Jorg J., additional, Görtz, Simon, additional, Gournelos, Elena, additional, Grahame, Rodney, additional, Grainger, Andrew J., additional, Gravallese, Ellen M., additional, Greenberg, Jeffrey D., additional, Hagley, Karlene, additional, Hakim, Alan J., additional, Hamuryudan, Vedat, additional, Haraoui, Boulos, additional, Harder, Adam, additional, Harley, John B., additional, Harris, E. Nigel, additional, Hashkes, Philip J., additional, Hawker, Gillian, additional, Hawkins, Philip N., additional, Heiberg, Turid, additional, Heinegård, Dick, additional, Helfgott, Simon M., additional, Heller, Jenny E., additional, Herrick, Ariane L., additional, Higgins, Laurence D., additional, Gaston, J. S. Hill, additional, Hochberg, Marc C., additional, Hoffmann, Markus, additional, Holers, V. Michael, additional, Holick, Michael F., additional, Holroyd, Christopher, additional, Hübscher, Osvaldo, additional, Huizinga, Tom W.J., additional, Hunter, David J., additional, Husni, M. Elaine, additional, Inman, Robert D., additional, Isaac, Zacharia, additional, Iversen, Maura D., additional, Jabs, Douglas A., additional, James, Hayley, additional, Javier, Rose-Marie, additional, Jayne, David, additional, Johnsen, Alyssa K., additional, Jordan, Joanne M., additional, Joy, Melanie S., additional, Kaisho, Tsuneyasu, additional, Kallenberg, Cees G.M., additional, Kanno, Yuka, additional, Karlson, Elizabeth W., additional, Kassimos, Dimitrios G., additional, Kastner, Daniel L., additional, Katz, Jeffrey N., additional, Kavanaugh, Arthur, additional, Kay, Jonathan, additional, Kelly, Jennifer A., additional, Keystone, Edward, additional, Khamashta, Munther A., additional, Khanna, Dinesh, additional, Kim, Peter W., additional, Kjeken, Ingvild, additional, Koch, Alisa E., additional, Koff, Matthew F., additional, Kraus, Virginia Byers, additional, Kremers, Hillal Maradit, additional, Krug, Hollis Elaine, additional, Kumar, Pradeep, additional, Kvien, Tore K., additional, Lafyatis, Robert, additional, Landau, Talia, additional, Landewé, Robert B.M., additional, Langford, Carol A., additional, Laxer, Ronald M., additional, Learch, Thomas J., additional, Leirisalo-Repo, Marjatta, additional, Lewith, George T., additional, Li, Yi, additional, Liao, Katherine P., additional, Littlejohn, Geoffrey, additional, Lockshin, Michael D., additional, Lorenzo, Pilar, additional, Luger, Thomas A., additional, Lundberg, Ingrid E., additional, Luthra, Harvinder S., additional, Machold, Klaus P., additional, Mackenzie, C. Ronald, additional, Mahowald, Maren Lawson, additional, Mahr, Alfred D., additional, Marini, Joan C., additional, Markalanda, Eresha, additional, Marquez, Javier, additional, Martel-Pelletier, Johanne, additional, Martin-Mola, Emilio, additional, Martinez-Lavin, Manuel, additional, Massarotti, Elena M., additional, Matteson, Eric L., additional, Mayes, Maureen, additional, Mayosi, Bongani M., additional, McAlindon, Timothy, additional, McCallum, Rex M., additional, McCarthy, Geraldine, additional, McCune, W. Joseph, additional, McGann, Stephany A., additional, McGonagle, Dennis, additional, McLean, Lachy, additional, Mease, Philip J., additional, Merkel, Peter A., additional, Mikdashi, Jamal A., additional, Miller, Frederick W., additional, Miller, Paul D., additional, Minden, Kirsten, additional, Mitsias, Dimitris I., additional, Mody, Girish M., additional, Monach, Paul A., additional, Moreland, Larry W., additional, Moutsopoulos, Haralampos M., additional, Namur, Gauthier, additional, Naredo, Esperanza, additional, Nashel, David J., additional, Nelson, Amanda E., additional, Newman, Stanton P., additional, Nossent, Johannes C., additional, Nöth, Ulrich, additional, O’Connor, Philip, additional, Oddis, Chester V., additional, Olsson, K. Sigvard, additional, Ombrello, Michael J., additional, Orcel, Philippe, additional, O'Shea, John J., additional, Paget, Stephen A., additional, Patrono, Carlo, additional, Pelletier, Jean-Pierre, additional, Pierangeli, Silvia, additional, Pierce, Heather, additional, Pilkington, Clarissa A., additional, Pillinger, Michael H., additional, Pineda, Carlos, additional, Plenge, Robert M., additional, Pricop, Luminita, additional, Rackwitz, Lars, additional, Ramani, Gautam, additional, Ravelli, Angelo, additional, Reeves, Westley H., additional, Remmers, Elaine F., additional, Repo, Heikki, additional, Requena, Luis, additional, Ribbens, Clio, additional, Riley, Graham, additional, Ritchlin, Christopher, additional, Rosas, Ivan O., additional, Roubenoff, Ronenn, additional, Rowan, A.D., additional, Rudwaleit, Martin, additional, Saag, Kenneth G., additional, Salmon, Jane E., additional, Salonen, David C., additional, Salter, Donald M., additional, Salzberg, Daniel J., additional, Sambrook, Philip N., additional, Sanofsky, Benjamin, additional, Saxne, Tore, additional, Schaible, Hans-Georg, additional, Schett, Georg, additional, Schmitz, Nicole, additional, Schon, Lew C., additional, Schumacher, H. Ralph, additional, Scott, David G.I., additional, Seidelmann, Brooke, additional, Sestak, Andrea L., additional, Seton, Margaret, additional, Shadick, Nancy A., additional, Shapiro, Lauren, additional, Shi, Lewis L., additional, Sidiropoulos, Prodromos, additional, Siegel, Richard M., additional, Sieper, Joachim, additional, Silver, Richard M., additional, Silverberg, Shonni J., additional, Simard, Julia F., additional, Simmons, Barry P., additional, Simms, Robert W., additional, Sims, John, additional, Singer, Nora G., additional, Smith, Malcolm D., additional, Smith, Stacy E., additional, Smolen, Josef S., additional, Spector, Tim D., additional, St. Clair, E. William, additional, Steen, Virginia D., additional, Steiner, Günter, additional, Steinert, Andre F., additional, Stone, John H., additional, Stone, Millicent A., additional, Straub, Rainer H., additional, Symmons, Deborah P.M., additional, Szekanecz, Zoltán, additional, Szer, Ilona S., additional, Tak, Paul P., additional, Tavoni, Antonio, additional, Taylor, Peter C., additional, Terkeltaub, Robert, additional, Thabet, Mohamed M., additional, Thorne, Jennifer E., additional, Tsokos, George C., additional, Tuan, Rocky S., additional, Turesson, Carl, additional, Tzioufas, Athanasios G., additional, Uber, Patricia A., additional, van den Berg, Wim B., additional, van der Heijde, Désirée, additional, van Gaalen, Floris A., additional, Varga, John, additional, Vassilopoulos, Dimitrios, additional, Vasudevan, Archana R., additional, Venables, Patrick J.W., additional, Vital, Edward M., additional, Wakefield, Richard J., additional, Walker, Jennifer G., additional, Ward, Robert J., additional, Watts, Richard, additional, Wedderburn, Lucy R., additional, Weinblatt, Michael E., additional, Weir, Matthew R., additional, Wenham, Claire Y.J., additional, West, Sterling G., additional, Weyand, Cornelia M., additional, White, Kenneth E., additional, Williams, Frances M.K., additional, Winthrop, Kevin L., additional, Woolf, Anthony D., additional, Worthington, Jane, additional, Wright, John, additional, Yazici, Hasan, additional, Yazici, Yusuf, additional, York, John R., additional, Young, D.A., additional, Yurdakul, Sebahattin, additional, Zhai, Guangju, additional, Zhang, Yuqing, additional, and Zhuang, Haoyang, additional

Published
2011
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14. association of smoking with immunoglobulin G4–related disease: a case–control study.

Author

Wallwork, Rachel, Perugino, Cory A, Fu, Xiaoqing, Harkness, Tyler, Zhang, Yuqing, Choi, Hyon K, Stone, John H, and Wallace, Zachary S

Subjects
RESEARCH, CONFIDENCE intervals, CASE-control method, FIBROSIS, RISK assessment, MATHEMATICAL variables, SMOKING, LOGISTIC regression analysis, ODDS ratio
Abstract

Objective To evaluate the association between cigarette smoking and the odds of IgG4-related disease (IgG4-RD). Methods We performed a case–control study of patients with IgG4-RD compared in a 1:5 ratio with age-, race- and sex-matched controls. We included cases evaluated at the Massachusetts General Hospital, a hospital within the Mass General Brigham (MGB) System. Controls were identified from the MGB Biobank. Smoking status at the date of IgG4-RD diagnosis or corresponding index date was determined. Conditional logistic regression was used to estimate the association between cigarette smoking and the odds of having IgG4-RD. Results There were 234 IgG4-RD cases and 1170 controls. The mean age (59 years), sex (62% male) and race (75% white) were well balanced. IgG4-RD cases were more likely to be current smokers compared with controls [25 (11%) vs 70 (6%); odds ratio (OR) 1.79 (95% CI 1.08, 2.95)]. This association was strongest among female cases [13 (14%) vs 19 (4%);, OR 3.79 (95% CI 1.71, 8.39)] and those with retroperitoneal fibrosis [RPF; 13 (28%) vs 13 (6%);, OR 6.93 (95% CI 2.78, 17.26)] or normal IgG4 concentrations [21 (21%) vs 21 (4%); OR 6.22 (95% CI 3.09, 12.49)]. When RPF cases were excluded, there was no longer an association between current smoking and the odds of having IgG4-RD [12 (6%) vs 57 (6%); OR 0.95 (95% CI 0.49, 1.86)]. Conclusion Being a current smoker is associated with greater odds of having IgG4-RD, especially among women and those with RPF or normal IgG4 concentrations. Current smoking is the first recognized modifiable risk factor for IgG4-RD. [ABSTRACT FROM AUTHOR]

Published
2021
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15. O26 Effects of baseline prednisone dose on remission and disease flare in patients with giant cell arteritis treated with tocilizumab in the GiACTA trial

Author

Stone, John H, primary, Tuckwell, Katie, additional, Dimonaco, Sophie, additional, Klearman, Micki, additional, Aringer, Martin, additional, Blockmans, Daniel, additional, Brouwer, Elisabeth, additional, Cid, Maria C, additional, Dasgupta, Bhaskar, additional, Rech, Juergen, additional, Salvarani, Carlo, additional, Schulze-Koops, Hendrik, additional, Schett, Georg, additional, Spiera, Robert F, additional, Unizony, Sebastian H, additional, and Collinson, Neil, additional

Published
2019
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16. 272 Acute phase reactant levels and prednisone doses at disease flare in patients with giant cell arteritis: prospective data from the GiACTA trial

Author

Stone, John H, primary, Tuckwell, Katie, additional, Dimonaco, Sophie, additional, Klearman, Micki, additional, Aringer, Martin, additional, Blockmans, Daniel, additional, Brouwer, Elisabeth, additional, Cid, Maria C, additional, Dasgupta, Bhaskar, additional, Rech, Juergen, additional, Salvarani, Carlo, additional, Schulze-Koops, Hendrik, additional, Schett, Georg, additional, Spiera, Robert, additional, Unizony, Sebastian H, additional, and Collinson, Neil, additional

Published
2019
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18. 172. THE ASSOCIATION OF DIFFERENCES IN LIPID PARAMETERS WITH DISEASE ACTIVITY IN ANCA-ASSOCIATED VASCULITIS (AAV)

Author

Wallace, Zachary, primary, Fu, Serena, additional, Liao, Katherine, additional, Zhang, Yuqing, additional, Kallenberg, Cees G.M, additional, Langford, Carol A, additional, Merkel, Peter A, additional, Seo, Philip, additional, Specks, Ulrich, additional, Spiera, Robert, additional, St. Clair, E. William, additional, Choi, Hyon, additional, and Stone, John H, additional

Published
2019
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19. All-cause and cause-specific mortality in ANCA-associated vasculitis: overall and according to ANCA type.

Author

Wallace, Zachary S, Fu, Xiaoqing, Harkness, Tyler, Stone, John H, Zhang, Yuqing, and Choi, Hyon

Subjects
CARDIOVASCULAR diseases, CAUSES of death, INFECTION, RESPIRATORY diseases, TUMORS, VASCULITIS, PROPORTIONAL hazards models, ANTINEUTROPHIL cytoplasmic antibodies
Abstract

Objective The objective of this study was to evaluate causes of death in a contemporary inception cohort of ANCA-associated vasculitis patients, stratifying the analysis according to ANCA type. Methods We identified a consecutive inception cohort of patients newly diagnosed with ANCA-associated vasculitis from 2002 to 2017 in the Partners HealthCare System and determined vital status through the National Death Index. We determined cumulative mortality incidence and standardized mortality ratios (SMRs) compared with the general population. We compared MPO- and PR3-ANCA+ cases using Cox regression models. Results The cohort included 484 patients with a mean diagnosis age of 58 years; 40% were male, 65% were MPO-ANCA+, and 65% had renal involvement. During 3385 person-years (PY) of follow-up, 130 patients died, yielding a mortality rate of 38.4/1000 PY and a SMR of 2.3 (95% CI: 1.9, 2.8). The most common causes of death were cardiovascular disease (CVD; cumulative incidence 7.1%), malignancy (5.9%) and infection (4.1%). The SMR for infection was greatest for both MPO- and PR3-ANCA+ patients (16.4 and 6.5). MPO-ANCA+ patients had an elevated SMR for CVD (3.0), respiratory disease (2.4) and renal disease (4.5). PR3- and MPO-ANCA+ patients had an elevated SMR for malignancy (3.7 and 2.7). Compared with PR3-ANCA+ patients, MPO-ANCA+ patients had a higher risk of CVD death [hazard ratio 5.0 (95% CI: 1.2, 21.2]; P = 0.03]. Conclusion Premature ANCA-associated vasculitis mortality is explained by CVD, infection, malignancy, and renal death. CVD is the most common cause of death, but the largest excess mortality risk in PR3- and MPO-ANCA+ patients is associated with infection. MPO-ANCA+ patients are at higher risk of CVD death than PR3-ANCA+ patients. [ABSTRACT FROM AUTHOR]

Published
2020
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22. Pharmacokinetics of rituximab and clinical outcomes in patients with anti-neutrophil cytoplasmic antibody associated vasculitis

Author

Cornec, Divi, primary, Kabat, Brian F, additional, Mills, John R, additional, Cheu, Melissa, additional, Hummel, Amber M, additional, Schroeder, Darrell R, additional, Cascino, Matthew D, additional, Brunetta, Paul, additional, Murray, David L, additional, Snyder, Melissa R, additional, Fervenza, Fernando, additional, Hoffman, Gary S, additional, Kallenberg, Cees G M, additional, Langford, Carol A, additional, Merkel, Peter A, additional, Monach, Paul A, additional, Seo, Philip, additional, Spiera, Robert F, additional, St Clair, E William, additional, Stone, John H, additional, Barnidge, David R, additional, and Specks, Ulrich, additional

Published
2018
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24. P2_19 High Bartonella Seroprevalence in Proteinase 3-Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis

Author

Mahr, Alfred, primary, Edouard, Sophie, additional, Cornec, Divi, additional, Guilpain, Philippe, additional, Hoffman, Gary S., additional, Kallenberg, Cees G.M., additional, Karnell, Fredrick, additional, Langford, Carol A., additional, Merkel, Peter A., additional, Monach, Paul A., additional, Pichon, Maud, additional, St. Clair, E. William, additional, Seo, Philip, additional, Spiera, Robert F., additional, Ytterberg, Steven R., additional, Stone, John H., additional, Raoult, Didier, additional, and Specks, Ulrich, additional

Published
2017
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26. IgG4-related disease of the mitral and aortic valves presenting as rapid, recurrent prosthetic valve failure.

Author

Katz, Guy, Victor, Brett, Binder, Adam, Bhattacharyya, Siddharth, and Stone, John H

Subjects
AORTIC valve diseases, AORTIC stenosis, BIOPSY, DEATH, ECHOCARDIOGRAPHY, PROSTHETIC heart valves, LUNGS, MITRAL stenosis, MITRAL valve diseases, COMPLICATIONS of prosthesis
Abstract

The article describes the case of a 78-year-old male with severe valvular heart disease requiring multiple valve replacements and repairs. Topics discussed include findings on transesophageal echocardiogram, his treatment of prednisone followed by rituximab following a lung biopsy showing chronic pneumonitis and interstitial fibrosis with dense IgG4-positive plasmacytic infiltration, and clinical characteristics of IgG4-related disease.

Published
2021
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28. Contributors

Author

Abeles, Aryeh M., Abelson, Abby G., Abhishek, Abhishek, Abramson, Steven B., Adams, Michael A., Adlam, David M., Aigner, Thomas, Akira, Shizuo, Aksentijevich, Ivona, Aletaha, Daniel, Aliprantis, Antonios O., Allaart, Cornelia F., Allen, Pamela G., Altman, Roy D., Aringer, Martin, Ascherman, Dana P., Assassi, Shervin, Atamas, Sergei P., Baer, Alan N., Baeten, Dominique, Baker, Nancy, Balsa, Alejandro, Barnsley, Les, Bathon, Joan M., Becker, Michael A., Belch, Jill JF, Bellamy, Nicholas, Bellido, Teresita, Benitez, R. Michael, Benjamin, Michael, Beresford, Michael W., Berman, Brian M., Bermas, Bonnie Lee, Bertsias, George, Bilezikian, John P., Blazar, Philip E., Bleasel, Jane F., Böhm, Markus, Boileau, Christelle, Bolster, Marcy B., Bombardieri, Stefano, Bonnick, Sydney, Boumpas, Dimitrios T., Brasington, Richard D., Jr., Breedveld, Ferdinand, Brien, Earl W., Brower, Anne C., Brown, Matthew A., Bruce, Ian N., Bugbee, William D., Bukhari, Marwan A.S., Burgos-Vargas, Rubén, Burns, Jane C., Burr, David B., Cagnoli, Patricia C., Calabrese, Leonard H., Callen, Jeffrey P., Canoso, Juan J., Cavallo, Sabrina, Cawston, Tim E., Chard, Michael Denis, Chen, Lan X., Choy, Ernest H.S., Clauw, Daniel J., Clements, Philip J., Colburn, Nona T., Coleman, Laura A., Conaghan, Philip G., Cooper, Cyrus, Cosman, Felicia, Costenbader, Karen H., Creamer, Paul, Crispin, José C., Criswell, Lindsey A., Cronstein, Bruce N., Cross, Raymond, Cusano, Natalie E., Cush, John J., Cutolo, Maurizio, D’Agati, Vivette, Dagfinrud, Hanne, Daikh, David I., Dalton, Seamus E., Dass, Shouvik, David, Jean-Pierre, Davis, Aileen, Deal, Chad L., De Ceulaer, Karel, Deighton, Chris, Dellaripa, Paul F., Rossa, Alessandra Della, Dempster, David, Dennison, Elaine, Denton, Christopher P., Denton, John, Dhawale, Roshan, Doherty, Michael, Dolan, Patricia, Donn, Rachelle, Dooley, Mary Anne, Dougados, Maxime, Drummond, Michael F., Dyer, George S.M., Earp, Brandon E., Edwards, N. Lawrence, Ellender, Patrick, Emery, Paul, Espinoza, Luis R., Farber, Joshua M., Fasth, Anders, Feldman, Debbie, Felson, David T., Fitzgerald, G. Kelley, Flores, Raymond H., Fox, David A., Francomano, Clair A., Freemont, Anthony J., Fresko, Izzet, Fricka, Kevin B., Furst, Daniel E., Gabay, Cem, Gabriel, Sherine E., Galarraga, Bernat, Gäre, Boel Andersson, Garnero, Patrick, Gensler, Lianne S., Gerlag, Danielle M., Geusens, Piet P., Giles, Jon T., Ginzler, Ellen M., Gizinski, Alison M., Gold, Garry, Gonzalez-Rivera, Tania, Gordon, Caroline, Gorodkin, Rachel, Goronzy, Jorg J., Görtz, Simon, Gournelos, Elena, Grahame, Rodney, Grainger, Andrew J., Gravallese, Ellen M., Greenberg, Jeffrey D., Hagley, Karlene, Hakim, Alan J., Hamuryudan, Vedat, Haraoui, Boulos, Harder, Adam, Harley, John B., Harris, E. Nigel, Hashkes, Philip J., Hawker, Gillian, Hawkins, Philip N., Heiberg, Turid, Heinegård, Dick, Helfgott, Simon M., Heller, Jenny E., Herrick, Ariane L., Higgins, Laurence D., Gaston, J. S. Hill, Hochberg, Marc C., Hoffmann, Markus, Holers, V. Michael, Holick, Michael F., Holroyd, Christopher, Hübscher, Osvaldo, Huizinga, Tom W.J., Hunter, David J., Husni, M. Elaine, Inman, Robert D., Isaac, Zacharia, Iversen, Maura D., Jabs, Douglas A., James, Hayley, Javier, Rose-Marie, Jayne, David, Johnsen, Alyssa K., Jordan, Joanne M., Joy, Melanie S., Kaisho, Tsuneyasu, Kallenberg, Cees G.M., Kanno, Yuka, Karlson, Elizabeth W., Kassimos, Dimitrios G., Kastner, Daniel L., Katz, Jeffrey N., Kavanaugh, Arthur, Kay, Jonathan, Kelly, Jennifer A., Keystone, Edward, Khamashta, Munther A., Khanna, Dinesh, Kim, Peter W., Kjeken, Ingvild, Koch, Alisa E., Koff, Matthew F., Kraus, Virginia Byers, Kremers, Hillal Maradit, Krug, Hollis Elaine, Kumar, Pradeep, Kvien, Tore K., Lafyatis, Robert, Landau, Talia, Landewé, Robert B.M., Langford, Carol A., Laxer, Ronald M., Learch, Thomas J., Leirisalo-Repo, Marjatta, Lewith, George T., Li, Yi, Liao, Katherine P., Littlejohn, Geoffrey, Lockshin, Michael D., Lorenzo, Pilar, Luger, Thomas A., Lundberg, Ingrid E., Luthra, Harvinder S., Machold, Klaus P., Mackenzie, C. Ronald, Mahowald, Maren Lawson, Mahr, Alfred D., Marini, Joan C., Markalanda, Eresha, Marquez, Javier, Martel-Pelletier, Johanne, Martin-Mola, Emilio, Martinez-Lavin, Manuel, Massarotti, Elena M., Matteson, Eric L., Mayes, Maureen, Mayosi, Bongani M., McAlindon, Timothy, McCallum, Rex M., McCarthy, Geraldine, McCune, W. Joseph, McGann, Stephany A., McGonagle, Dennis, McLean, Lachy, Mease, Philip J., Merkel, Peter A., Mikdashi, Jamal A., Miller, Frederick W., Miller, Paul D., Minden, Kirsten, Mitsias, Dimitris I., Mody, Girish M., Monach, Paul A., Moreland, Larry W., Moutsopoulos, Haralampos M., Namur, Gauthier, Naredo, Esperanza, Nashel, David J., Nelson, Amanda E., Newman, Stanton P., Nossent, Johannes C., Nöth, Ulrich, O’Connor, Philip, Oddis, Chester V., Olsson, K. Sigvard, Ombrello, Michael J., Orcel, Philippe, O'Shea, John J., Paget, Stephen A., Patrono, Carlo, Pelletier, Jean-Pierre, Pierangeli, Silvia, Pierce, Heather, Pilkington, Clarissa A., Pillinger, Michael H., Pineda, Carlos, Plenge, Robert M., Pricop, Luminita, Rackwitz, Lars, Ramani, Gautam, Ravelli, Angelo, Reeves, Westley H., Remmers, Elaine F., Repo, Heikki, Requena, Luis, Ribbens, Clio, Riley, Graham, Ritchlin, Christopher, Rosas, Ivan O., Roubenoff, Ronenn, Rowan, A.D., Rudwaleit, Martin, Saag, Kenneth G., Salmon, Jane E., Salonen, David C., Salter, Donald M., Salzberg, Daniel J., Sambrook, Philip N., Sanofsky, Benjamin, Saxne, Tore, Schaible, Hans-Georg, Schett, Georg, Schmitz, Nicole, Schon, Lew C., Schumacher, H. Ralph, Jr., Scott, David G.I., Seidelmann, Brooke, Sestak, Andrea L., Seton, Margaret, Shadick, Nancy A., Shapiro, Lauren, Shi, Lewis L., Sidiropoulos, Prodromos, Siegel, Richard M., Sieper, Joachim, Silver, Richard M., Silverberg, Shonni J., Simard, Julia F., Simmons, Barry P., Simms, Robert W., Sims, John, Singer, Nora G., Smith, Malcolm D., Smith, Stacy E., Smolen, Josef S., Spector, Tim D., St. Clair, E. William, Steen, Virginia D., Steiner, Günter, Steinert, Andre F., Stone, John H., Stone, Millicent A., Straub, Rainer H., Symmons, Deborah P.M., Szekanecz, Zoltán, Szer, Ilona S., Tak, Paul P., Tavoni, Antonio, Taylor, Peter C., Terkeltaub, Robert, Thabet, Mohamed M., Thorne, Jennifer E., Tsokos, George C., Tuan, Rocky S., Turesson, Carl, Tzioufas, Athanasios G., Uber, Patricia A., van den Berg, Wim B., van der Heijde, Désirée, van Gaalen, Floris A., Varga, John, Vassilopoulos, Dimitrios, Vasudevan, Archana R., Venables, Patrick J.W., Vital, Edward M., Wakefield, Richard J., Walker, Jennifer G., Ward, Robert J., Watts, Richard, Wedderburn, Lucy R., Weinblatt, Michael E., Weir, Matthew R., Wenham, Claire Y.J., West, Sterling G., Weyand, Cornelia M., White, Kenneth E., Williams, Frances M.K., Winthrop, Kevin L., Woolf, Anthony D., Worthington, Jane, Wright, John, Yazici, Hasan, Yazici, Yusuf, York, John R., Young, D.A., Yurdakul, Sebahattin, Zhai, Guangju, Zhang, Yuqing, and Zhuang, Haoyang

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