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2. Upregulated expression of FFAR2 and SOC3 genes is associated with gout.

Author

Orji, Oliver C, López-Domínguez, Maria B, Sandoval-Plata, Gabriela, Guetta-Baranes, Tamar, Valdes, Ana M, Doherty, Michael, Morgan, Kevin, and Abhishek, Abhishek

Subjects
HYPERURICEMIA, ANALYSIS of variance, CROSS-sectional method, CELL receptors, GENE expression, CELLULAR signal transduction, DESCRIPTIVE statistics, URIC acid, DATA analysis software, GOUT, CARRIER proteins, CRYSTALLIZATION, LONGITUDINAL method
Abstract

Objective To examine the expression of Free fatty acid receptor 2 (FFAR2) and Suppressor of cytokine signalling 3 (SOCS3) genes in asymptomatic hyperuricaemia (AH), AH with MSU crystal deposition, inter-critical gout and gout flare. Methods Study participants (n  = 120) comprised 34 people with serum urate (SU) <360 μmol/l, 69 with AH ± MSU crystal deposition and 17 with a gout flare. Sixteen of the 17 patients with a gout flare attended a second visit 6–12 weeks later. Gene expression levels were assessed using RT-qPCR and results computed as fold changes (FC) after normalization to the reference gene. Results FFAR2 was significantly upregulated during gout flares (FC = 2.9) compared with normal SU, AH, and AH + MSU crystal deposition (FC = 1.1, P  < 0.0001 for each comparison). FFAR2 was also significantly upregulated during inter-critical gout (FC = 1.8) compared with normal SU, AH and AH + MSU (FC = 1.1, P  < 0.001 for each comparison). SOCS3 was significantly upregulated during gout flares (FC = 3.4) compared with normal SU, AH, and AH + MSU crystal deposition (FC = 1.1, 1.1 and 1.2, respectively, P  < 0.0001 for each comparison). SOCS3 was also upregulated during inter-critical gout (FC = 2.1) compared with normal SU (P  = 0.02) and AH (P  = 0.006) (FC = 1.1 and 1.2, respectively). FFAR2 expression was upregulated during gout flare compared with inter-critical gout and SOCS3 expression showed negative correlation with flare duration (r = –0.49, P  < 0.05). Conclusion FFAR2 upregulation is associated with gout and may trigger gout flares. SOCS3 may have a role in amelioration of gout flares. [ABSTRACT FROM AUTHOR]

Published
2023
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4. Contributors

Author

Abdellatif, Engy, primary, Abeles, Aryeh M., additional, Abelson, Abby G., additional, Abhishek, Abhishek, additional, Abramson, Steven B., additional, Adachi, Jonathan D., additional, Adams, Michael A., additional, Aigner, Thomas, additional, Akira, Shizuo, additional, Aletaha, Daniel, additional, Aliprantis, Antonios O., additional, Almeida de Jesus, Adriana, additional, Altman, Roy D., additional, Amigo, Mary-Carmen, additional, Aringer, Martin, additional, Ascherman, Dana P., additional, Assassi, Shervin, additional, Atamas, Sergei P., additional, Azevedo, Pedro Ming, additional, Baer, Alan N., additional, Baeten, Dominique, additional, Baines, Colin, additional, Baker, Nancy A., additional, Balogh, Emese, additional, Balsa, Alejandro, additional, Baraliakos, Xenofon, additional, Bardin, Thomas, additional, Barnsley, Les, additional, Bathon, Joan M., additional, Bauch, Angela, additional, Belch, Jill J.F., additional, Bellamy, Nicholas, additional, Bellido, Teresita, additional, Benjamin, Michael, additional, Beresford, Michael W., additional, Berman, Brian, additional, Bermas, Bonnie Lee, additional, Bertsias, George, additional, Bilezikian, John P., additional, Bilginer, Yelda, additional, Birnbaum, Julius, additional, Bishop, Felicity L., additional, Bleasel, Jane F., additional, Böhm, Markus, additional, Bolster, Marcy B., additional, Bombardieri, Stefano, additional, Bonelli, Michael, additional, Bonnick, Sydney L., additional, Boumpas, Dimitrios T., additional, Bozec, Aline, additional, Brasington, Richard D., additional, Braun, Juergen, additional, Brown, Matthew A., additional, Bruce, Ian N., additional, Bugbee, William D., additional, Bukhari, Marwan A.S., additional, Burgos-Vargas, Rubén, additional, Burmester, Gerd-Rüdiger, additional, Burns, Jane C., additional, Burr, David B., additional, Buttgereit, Frank, additional, Bykerk, Vivian P., additional, Calabrese, Leonard H., additional, Callen, Jeffrey P., additional, Cavallo, Sabrina, additional, Cawston, Tim E., additional, Chandran, Vinod, additional, Chard, Michael Denis, additional, Chaudhary, Prateek, additional, Chen, Lan X., additional, Choi, Hyon K., additional, Choy, Ernest H., additional, Christopher-Stine, Lisa, additional, Chu, Alvina D., additional, Clauw, Daniel J., additional, Clements, Philip J., additional, Clowse, Megan E.B., additional, Coghlan, J. Gerry, additional, Conaghan, Philip G., additional, Cooper, Cyrus, additional, Costenbader, Karen H., additional, Creamer, Paul, additional, Crispín, José C., additional, Cronstein, Bruce N., additional, Cross, Raymond, additional, Cusano, Natalie E., additional, Cutolo, Maurizio, additional, D'Adamo, Chris, additional, D'Agati, Vivette, additional, D'Cruz, David P., additional, Dagfinrud, Hanne, additional, Daikh, David I., additional, Dalbeth, Nicola, additional, Dalton, Seamus E., additional, Dass, Shouvik, additional, Davis, Aileen M., additional, De Ceulaer, Karel, additional, Deal, Chad L., additional, Deane, Kevin D., additional, Della Rossa, Alessandra, additional, Dellaripa, Paul F., additional, Dennison, Elaine, additional, Denton, Christopher P., additional, Dieppe, Paul, additional, Doherty, Michael, additional, Dolan, Patricia, additional, Donn, Rachelle, additional, Dvorkina, Olga, additional, Dyer, George S.M., additional, Eastell, Richard, additional, Edwards, N. Lawrence, additional, Emery, Paul, additional, Erturan, Gurhan, additional, Espinoza, Luis R., additional, Eyre, Steve, additional, Fanouriakis, Antonios C., additional, Farber, Joshua, additional, Farrokhi, Shawn, additional, Fasth, Anders, additional, Feist, Eugen, additional, Feldman, Debbie, additional, Felson, David T., additional, Fisk, John D., additional, Fitzgerald, G. Kelley, additional, Flores, Raymond H., additional, Fox, David A., additional, Francomano, Clair A., additional, Frangos, Jennifer, additional, Freemont, Anthony J., additional, Fricka, Kevin B., additional, Furst, Daniel E., additional, Gabay, Cem, additional, Gadina, Massimo, additional, Gaston, J.S. Hill, additional, Gay, Steffen, additional, Gensler, Lianne S., additional, Geraldino-Pardilla, Laura, additional, Gerlag, Danielle M., additional, Ginzler, Ellen M., additional, Gizinski, Alison M., additional, Gladman, Dafna D., additional, Gold, Garry E., additional, Goldbach-Mansky, Raphaela, additional, Goldingay, Sarah, additional, Gordon, Sharon M., additional, Gorodkin, Rachel, additional, Goronzy, Jörg J., additional, Görtz, Simon, additional, Grahame, Rodney, additional, Grainger, Andrew J., additional, Gravallese, Ellen M., additional, Greenberg, Jeffrey D., additional, Gujar, Bansari, additional, Hagan, Matilda, additional, Hagley, Karlene, additional, Hakim, Alan J., additional, Hall, John C., additional, Hamuryudan, Vedat, additional, Hanly, John G., additional, Hanson, Eric P., additional, Haraoui, Boulos, additional, Harley, John B., additional, Hashkes, Philip J., additional, Hawker, Gillian A., additional, Hawkins, Philip N., additional, Heiberg, Turid, additional, Heinegård, Dick, additional, Helfgott, Simon M., additional, Ho, Pauline Y.P., additional, Hochberg, Marc C., additional, Hochman, Jacqueline, additional, Hodgkiss-Harlow, Chelsea J., additional, Hoffman, Robert W., additional, Hoffmann, Markus, additional, Holers, V. Michael, additional, Holick, Michael F., additional, Holroyd, Christopher, additional, Hübscher, Osvaldo, additional, Hunter, David J., additional, Husni, M. Elaine, additional, Inman, Robert D., additional, Isaac, Zacharia, additional, Iversen, Maura D., additional, Jabs, Douglas A., additional, Jackson, William, additional, Jaimungal, Sarada, additional, James, Judith A., additional, Javier, Rose-Marie, additional, Johnsen, Alyssa K., additional, Jordan, Joanne M., additional, Kaisho, Tsuneyasu, additional, Kallenberg, Cees G.M., additional, Kane, David, additional, Kapoor, Mohit, additional, Karlson, Elizabeth W., additional, Kassimos, Dimitrios G., additional, Kastner, Daniel L., additional, Katz, Jeffrey N., additional, Kay, Jonathan, additional, Kelly, Jennifer A., additional, Keystone, Edward, additional, Khamashta, Munther A., additional, Khanna, Dinesh, additional, Kjeken, Ingvild, additional, Koch, Alisa E., additional, Koff, Matthew F., additional, Kottyan, Leah, additional, Koutsogeorgopoulou, Loukia A., additional, Kraus, Virginia Byers, additional, Kumar, Pradeep, additional, Kvien, Tore K., additional, Lafyatis, Robert, additional, Landewé, Robert B.M., additional, Langford, Carol A., additional, Lau, Arthur N., additional, Laxer, Ronald M., additional, Learch, Thomas J., additional, Lewith, George, additional, Li, Yi, additional, Liao, Katherine P., additional, Littlejohn, Geoffrey, additional, Lorenzo, Pilar, additional, Luger, Thomas A., additional, Lundberg, Ingrid E., additional, Lundberg, Karin, additional, Machold, Klaus P., additional, MacKenzie, C. Ronald, additional, Mahr, Alfred D., additional, Manheimer, Eric, additional, Marini, Joan C., additional, Marquez, Javier, additional, Marsden, Debbie, additional, Martel-Pelletier, Johanne, additional, Martín-Mola, Emilio, additional, Martínez-Lavín, Manuel, additional, Massarotti, Elena M., additional, Matteson, Eric L., additional, Matzat, Stephen J., additional, Mayahi, Reza, additional, Mayes, Maureen Davidica, additional, McAlindon, Timothy, additional, McBain, Hayley, additional, McCarberg, Bill, additional, McCarthy, Edward F., additional, McCarthy, Geraldine, additional, McDermott, Michael F., additional, McGonagle, Dennis, additional, McLean, Lachy, additional, Merkel, Peter A., additional, Mikdashi, Jamal A., additional, Miller, Frederick W., additional, Miller, Paul D., additional, Minden, Kirsten, additional, Monach, Paul A., additional, Mulligan, Kathleen, additional, Namur, Gauthier, additional, Naredo, Esperanza, additional, Naylor, Kim E., additional, Nelson, Amanda E., additional, Newman, Stanton P., additional, Nordal, Ellen, additional, Nöth, Ulrich, additional, Ntatsaki, Eleana, additional, O'Shea, John J., additional, Oddis, Chester V., additional, Olivé, Alejandro, additional, Omair, Mohammed A., additional, Ombrello, Michael J., additional, Omisade, Antonina, additional, Ong, Voon H., additional, Önnerfjord, Patrik, additional, Orcel, Philippe, additional, Ospelt, Caroline, additional, Ozen, Seza, additional, Paget, Stephen A., additional, Patel, Dipak R., additional, Patrono, Carlo, additional, Pelletier, Jean-Pierre, additional, Pereira, Rosa Maria Rodrigues, additional, Pilkington, Clarissa A., additional, Pillinger, Michael H., additional, Pineda, Carlos, additional, Plenge, Robert M., additional, Price, Andrew, additional, Pricop, Luminita, additional, Rackwitz, Lars, additional, Ravelli, Angelo, additional, Redmond, Anthony C., additional, Reeves, Westley H., additional, Remmers, Elaine F., additional, Requena, Luis, additional, Ribbens, Clio, additional, Richardson, Bruce C., additional, Riera Alonso, Elena, additional, Riley, Graham, additional, Ritchlin, Christopher, additional, Ritter, Susan Y., additional, Rosas, Ivan O., additional, Rowan, Drew D., additional, Rudwaleit, Martin, additional, Rull, Marina, additional, Rygg, Marite, additional, Saag, Kenneth G., additional, Salmon, Jane E., additional, Salter, Donald M., additional, Salzberg, Daniel J., additional, Sambrook, Philip N., additional, Saxne, Tore, additional, Schaible, Hans-Georg, additional, Scher, Jose U., additional, Schett, Georg, additional, Schmitz, Nicole, additional, Schreiber, Benjamin, additional, Schumacher, H. Ralph, additional, Schwartz, Daniella Muallem, additional, Scott, David G.I., additional, Seton, Margaret, additional, Shapiro, Lauren M., additional, Sharby, Nancy, additional, Siegel, Jeffrey, additional, Siegel, Richard M., additional, Sieper, Joachim, additional, Silver, Richard M., additional, Silverberg, Shonni J., additional, Simard, Julia F., additional, Simmons, Barry P., additional, Simms, Robert W., additional, Singer, Nora G., additional, Smith, Malcolm D., additional, Smith, Stacy E., additional, Smolen, Josef S., additional, Spector, Tim D., additional, Steen, Virginia D., additional, Steere, Allen C., additional, Steiner, Günter, additional, Steinert, Andre F., additional, Stojan, George, additional, Stone, John H., additional, Strand, Vibeke, additional, Straub, Rainer H., additional, Streeten, Elizabeth A., additional, Superti-Furga, Giulio, additional, Symmons, Deborah P.M., additional, Szekanecz, Zoltan, additional, Tak, Paul P., additional, Tavoni, Antonio, additional, Taylor, Peter C., additional, Terkeltaub, Robert, additional, Thomas, Sarah S., additional, Thorne, Jennifer E., additional, Tobias, Jonathan H., additional, Tremoulet, Adriana H., additional, Tsokos, George C., additional, Tuan, Rocky S., additional, Turesson, Carl, additional, Unizony, Sebastian H., additional, Valdes, Ana M., additional, van den Berg, Wim B., additional, van der Heijde, Désirée, additional, van Vollenhoven, Ronald Frits, additional, Varga, John, additional, Vassilopoulos, Dimitrios, additional, Vital, Edward M., additional, Walker-Bone, Karen, additional, Wallace, Daniel J., additional, Warburton, Gary, additional, Ward, Robert J., additional, Watts, Richard, additional, Wechalekar, Mihir D., additional, Wedderburn, Lucy R., additional, Weinblatt, Michael E., additional, Weir, Matthew R., additional, Wenham, Claire Y.J., additional, West, Sterling G., additional, Weyand, Cornelia M., additional, White, Kenneth E., additional, Winthrop, Kevin L., additional, Wong, John B., additional, Woolf, Anthony D., additional, Worthington, Jane, additional, Xu, Huji, additional, Yazici, Hasan, additional, Young, D.A., additional, Yurdakul, Sebahattin, additional, Zhang, Yuqing, additional, and Zhuang, Haoyang, additional

Published
2015
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7. 090 DNA methylation and its relationship with musculoskeletal health in older adults from the Hertfordshire Cohort Study: findings from an epigenome-wide association study

Author

Curtis, Elizabeth M, primary, Titcombe, Philip, additional, Edwards, Mark, additional, Barton, Sheila, additional, Tsai, Pei-Chien, additional, Dennison, Elaine M, additional, Bell, Jordana, additional, Spector, Tim, additional, Valdes, Ana M, additional, Bell, Christopher G, additional, Harvey, Nicholas C, additional, and Cooper, Cyrus, additional

Published
2018
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9. Contributors

Author

Abelson, Abby G., Abramson, Steven B., Adachi, Jonathan D., Adams, Michael A., Aggarwal, Rohit, Aigner, Thomas, Akira, Shizuo, Albert, Daniel A., Aletaha, Daniel, Alevizos, Ilias, Allem, Kavitta B., Almehthel, Mohammed, Almohaya, Mohamed, Alonso, Elena Riera, Amigo, Mary-Carmen, Arden, Nigel K., Aringer, Martin, Arkema, Elizabeth V., Ascherman, Dana P., Atamas, Sergei P., Atkinson, Timothy J., Azeez, Maha A., Azevedo, Pedro M., Baer, Alan N., Baeten, Dominique, Baines, Colin P., Balsa, Alejandro, Baraliakos, Xenofon, Bardin, Thomas, Barnes, Jammie K., Barnsley, Les, Barr, Andrew J., Bathon, Joan M., Bauch, Angela, Bay-Jensen, Anne-Christine, Belch, Jill J.F., Bellamy, Nicholas, Bellido, Teresita, Benjamin, Michael, Bennell, Kim L., Beresford, Michael W., Berman, Brian, Bermas, Bonnie L., Bertsias, George, Bhalla, Sonal, Bilginer, Yelda, Birnbaum, Julius, Bleasel, Jane F., Block, Joel A., Blom, Ashley W., Böhm, Markus, Bonelli, Michael, Borchert, Grace, Boros, Christina A., Boumpas, Dimitrios T., Bozec, Aline, Brasington, Richard D., Jr., Braun, Jürgen, Brouwer, Elisabeth, Brown, Jacques P., Brown, Matthew A., Bruce, Ian N., Buch, Maya H., Buckley, Christopher D., Bugbee, William D., Burmester, Gerd-Rüdiger, Burns, Jane C., Burr, David B., Buttgereit, Frank, Bykerk, Vivian P., Calabrese, Leonard H., Callen, Jeffrey P., Carr, Andrew J., Carroll, Graeme J., Cavallo, Sabrina, Cervera, Ricard, Chaudhary, Prateek, Choi, Hyon K., Choy, Ernest H., Christopher-Stine, Lisa, Chu, Alvina D., Chung, Lorinda, Ciccia, Francesco, Clauw, Daniel J., Clinch, Jacqui, Clowse, Megan E.B., Coghlan, J. Gerard, Colbert, Robert A., Conaghan, Philip G., Cooper, Cyrus, Cooper, Robert G., Costenbader, Karen H., Cox, George L.D., Creamer, Paul, Cronstein, Bruce N., Cross, Raymond, Cutolo, Maurizio, D’Adamo, Chris, D’Agati, Vivette D., Daikh, David I., Dakin, Stephanie G., Dalbeth, Nicola, Davis, Aileen M., D’Cruz, David P., Ceulaer, Karel De, Rheum, Dipl, de Jesus, Adriana A., De Vita, Salvatore, de Wit, Maarten, Deal, Chad L., Deane, Kevin D., Dellaripa, Paul F., Dennison, Elaine, Denton, Christopher P., Dieppe, Paul, Dolan, Patricia, Doyle, Tracy J., Dyer, George S.M., Emery, Paul, Espinosa, Gerard, Espinoza, Luis R., Eyre, Stephen, Fanouriakis, Antonis C., Farber, Joshua, Fasth, Anders, Feist, Eugen, Feldman, Candace H., Feldman, Debbie, Filer, Andrew, Fiorentino, David F., Fisher, Benjamin A., Fisk, John D., Flores, Raymond H., Forbess, Lindsy, Fox, David A., Freemont, Anthony J., Fricka, Kevin B., Gabay, Cem, Gadina, Massimo, Gandolfo, Saviana, Gauntlett-Gilbert, Jeremy, Gay, Steffen, Gensler, Lianne S., Gerlag, Danielle M., Gold, Garry E., Goldbach-Mansky, Raphaela, Goldingay, Sarah J., Gómez-Puerta, José A., Goodman, Susan M., Gordon, Caroline, Gordon, Sharon M., Gorodkin, Rachel, Görtz, Simon, Grainger, Andrew J., Gravallese, Ellen M., Greenberg, Jeffrey D., Grieve, Sharon, Guilherme, Luiza, Gül, Ahmet, Gupta, Sarthak, Hagan, Matilda, Hagley, Karlene, Han, Shuhong, Hanly, John G., Hanson, Eric P., Haraoui, Boulos, Hardcastle, Sarah A., Harley, John B., Haroun, Tayseer G., Hashkes, Philip J., Hassan, Andrew Bassim, Haupt, Lukas, Hawker, Gillian A., Hawkins, Philip N., Heeringa, Peter, Heiberg, Turid, Heinegård, Dick, Helfgott, Simon M., Henriksen, Kim, Hinman, Rana S., Ho, Pauline Y.P., Hochberg, Marc C., Hoffmann, Markus H., Holick, Michael F., Holroyd, Christopher R., Holt, Cathy, Huizinga, Thomas W.J., Husni, M. Elaine, Inman, Robert D., Inoue, Dai, Isaac, Zacharia, Isaacs, John D., Iversen, Maura D., Jabs, Douglas A., Jaimungal, Sarada, James, Judith A., Javaid, M. Kassim, Javidan, Pooya, Javier, Rose-Marie, Jefferis, Roy, Johnsen, Alyssa K., Jordan, Joanne M., Joyce, Andrew A., Jung, Michelle, Kado, Ruba, Kaisho, Tsuneyasu, Kallenberg, Cees G.M., Kane, David, Kaplan, Mariana J., Karsdal, Morten Asser, Kassimos, Dimitrios G., Kastner, Daniel L., Kawano, Mitsuhiro, Kay, Jonathan, Keating, Richard M., Kelly, Jennifer A., Kendler, David, Khamashta, Munther A., Khan, Irfan R., Khanna, Dinesh, Klokkerud, Mari, Kolstad, Kathleen D., Kottyan, Leah, Kraus, Virginia Byers, Kvien, Tore K., Lafyatis, Robert, Landewé, Robert B.M., Langford, Carol A., Lau, Arthur N., Lavin, Robert A., Laxer, Ronald M., Learch, Thomas J., Leatherwood, Cianna, Lewis, Jennifer S., Lewith, George, Liao, Katherine P., Lightfoot, Adam P., Littlejohn, Geoffrey O., Lorenzo, Pilar, Lories, Rik J.U., Luger, Thomas A., Lundberg, Ingrid E., Luqmani, Raashid A., Lythgoe, Hanna M., MacDougall, Kristin J., MacKenzie, C. Ronald, Manasson, Julia, Mangham, David Charles, Mao, Rong, March, Lyn M., Marqués, Alejandro Olivé, Márquez, Javier, Martín-Mola, Emilio, Martínez-Lavín, Manuel, Matteson, Eric L., Matzat, Stephen J., Mayes, Maureen D., McAlindon, Timothy, McCabe, Candy S., McCarthy, Edward F., McCarthy, Geraldine M., McDermott, Michael F., McGonagle, Dennis, McLean, Lachy, Ian Melville, Andrew Robert, Michou, Laëtitia, Middleton, Rob, Mikdashi, Jamal A., Miller, Frederick W., Miller, Paul D., Minden, Kirsten, Miner, Jonathan J., Moe, Rikke Helene, Möller, Ingrid, Monach, Paul A., Mons, Barend, Myasoedova, Elena, Nam, Jackie L., Namur, Gauthier, Naredo, Esperanza, Neerinckx, Barbara, Nelson, Amanda E., Nicolson, Philippa J.A., Nieves, César E. Fors, Nordal, Ellen B., Nöth, Ulrich, Ntatsaki, Eleana, Oddis, Chester V., Omar, Ahmed, Ombrello, Michael J., Omisade, Antonina, Ong, Voon H., Önnerfjord, Patrik, Orcel, Philippe, Orr, Carl, O'Shea, John J., Ospelt, Caroline, Özen, Seza, Parker, Matthew J.S., Patrono, Carlo, Pilkington, Clarissa A., Pillinger, Michael H., Pineda, Carlos, Pipitone, Nicolò, Poddubnyy, Denis, Pope, Janet E., Postolova, Anna, Price, Andrew, Quartuccio, Luca, Rackwitz, Lars, Radner, Helga, Raychaudhuri, Soumya, Redmond, Anthony C., Rees, Jonathan L., Reeves, Westley H., Rehaume, Linda M., Remmers, Elaine F., Requena, Luis, Reynolds, Gary, Ribbens, Clio, Richards, Bethan, Richardson, Bruce C., Richette, Pascal, Richter, Adrian, Ritchlin, Christopher T., Ritter, Susan Y., Robinson, William H., Rogers, Valerie, Rosas, Ivan O., Rosenthal, Ann K., Rowan, Andrew D., Rudwaleit, Martin, Rull, Marina, Rygg, Marite, Saag, Kenneth G., Salmon, Jane E., Salter, Donald M., Salvarani, Carlo, Sandell, Linda J., Sandigursky, Sabina, Saxne, Tore, Schaible, Hans-Georg, Scher, Jose U., Schett, Georg, Schiffenbauer, Adam I., Schiller, Alan L., Schlesinger, Naomi, Schreiber, Benjamin E., Schwartz, Daniella Muallem, Shapiro, Lauren M., Sharma, Leena, Siaton, Bernadette C., Siegel, Richard M., Sieper, Joachim, Simard, Julia Fridman, Simmons, Barry P., Simms, Robert W., Singer, Nora G., Smith, Judith A., Smith, Stacy E., Smolen, Josef S., Solomon, Daniel H., Stack, John, Stanley, David, Steen, Virginia D., Steere, Allen C., Steiner, Günter, Steinert, Andre F., Stojan, George, Strand, Vibeke, Straub, Rainer H., Streeten, Elizabeth A., Superti-Furga, Giulio, Tak, Paul P., Tang, Chen, Taylor, Peter C., Terkeltaub, Robert, Thomas, Beje, Thomas, Ranjeny, Thorne, Jennifer E., Tobias, Jonathan H., Tremoulet, Adriana H., Trouw, Leendert A., Tuan, Rocky S., Turesson, Carl, Umehara, Hisanori, Valdes, Ana M., van der Heijde, Désirée, van Vollenhoven, Ronald F., Vanderstukken, Joke, Varga, John, Vassilopoulos, Dimitrios, Veale, Douglas J., Viatte, Sebastien, Vincent, Tonia, Vital, Edward M., von Loga, Isabell S., Wallace, Daniel J., Walsh, Nicola, Warber, Sara L., Warburton, Gary, Ward, Robert J., Watts, Laura, Watts, Richard A., Wedderburn, Lucy R., Weinblatt, Michael E., Weir, Matthew R., Sr., Weisman, Michael H., Weiss, Pamela F., Wenham, Claire Y.J., West, Sterling G., White, Harriet Branford, White, Kenneth E., Wilkinson, David J., Williams, David E., Williams, Richard, Wilson, Hannah, Winthrop, Kevin L., Witt, Claudia M., Witzmann, Gerhard, Wong, John B., Woolf, Anthony D., Wordsworth, Paul B., Worthington, Jane, Wysham, Katherine D., Xu, Huji, Young, David A., Young, Stephen P., Yusof, Md Yuzaiful Md, Zhuang, Haoyang, and Zink, Angela

Published
2019
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11. Intercritical circulating levels of neo-epitopes reflecting matrixmetalloprotease-driven degradation as markers of gout and frequent gout attacks

Author

Valdes, Ana M., primary, Manon-Jensen, Tina, additional, Abhishek, Abhishek, additional, Jenkins, Wendy, additional, Siebuhr, Anne Sofie, additional, Karsdal, Morten A., additional, Doherty, Sally, additional, Zhang, Weiya, additional, Richardson, Helen, additional, Doherty, Michael, additional, and Bay-Jensen, Anne-Christine, additional

Published
2016
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12. Familial aggregation of rheumatoid arthritis and co-aggregation of autoimmune diseases in affected families: a nationwide population-based study.

Author

Chang-Fu Kuo, Grainge, Matthew J., Valdes, Ana M., Lai-Chu See, Kuang-Hui Yu, Shaw, S. W. Steven, Shue-Fen Luo, Weiya Zhang, and Doherty, Michael

Subjects
GENETICS of autoimmune diseases, AUTOIMMUNE diseases, INFLAMMATORY bowel diseases, PSORIASIS, GENETICS of rheumatoid arthritis, RHEUMATOID arthritis risk factors, SYSTEMIC lupus erythematosus, MULTIPLE sclerosis risk factors, SYSTEMIC scleroderma, TYPE 1 diabetes, MYOSITIS, SIBLINGS, CONFIDENCE intervals, DATABASES, HEALTH insurance, PARENTS, TWINS, PHENOTYPES, RELATIVE medical risk, PROPORTIONAL hazards models, DESCRIPTIVE statistics, DISEASE risk factors, DIABETES risk factors
Abstract

Objective. The aim was to estimate familial relative risk (RR) for RA and other autoimmune diseases and the genetic contribution to RA phenotypic variance (heritability). Methods. This study used the Taiwan National Health Insurance Research Database to identify all National Health Insurance registered beneficiaries (n = 23 658 577) in 2010; among them, 37 482 individuals had RA. We estimated familial RRs and 95% CIs of RA and other autoimmune diseases using marginal Cox proportional models and heritability of RA using a threshold liability model. Results. The RR (95% CI) for RA was 328.27 (135.95, 795.63) for twins of RA patients; 11.97 (8.68, 16.52) for siblings; 4.86 (4.16, 5.67) for parents; 4.65 (3.92, 5.50) for offspring; and 2.32 (1.83, 2.95) for spouses. Using a threshold liability model, we estimated that familial transmission was 59.4% (95% CI: 50.3, 69.5%) and that heritability was 43.5% (33.9, 54.1%). The RR (95% CI) in individuals with a first-degree relative with RA was 2.91 (2.49, 3.42) for SLE; 2.92 (1.62, 5.25) for SSc; 3.13 (2.50, 3.93) for primary SS; 0.95 (0.36, 2.51) for idiopathic inflammatory myositis; 1.96 (1.54, 2.48) for type 1 diabetes mellitus; 3.32 (1.82, 5.95) for multiple sclerosis; 1.31 (1.31, 2.43) for IBD; 2.76 (2.46, 3.10) for AS; and 1.65 (1.54, 1.77) for psoriasis. Conclusion. The risks of RA and other autoimmune diseases increased in individuals with an RA family history. Approximately two-thirds of RA phenotypic variation is explained by familial factors. [ABSTRACT FROM AUTHOR]

Published
2017
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