1. SMN - A chaperone for nuclear RNP social occasions?
- Author
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Raimer AC, Gray KM, and Matera AG
- Subjects
- Animals, Cell Nucleus metabolism, Coiled Bodies metabolism, Disease Susceptibility, Humans, Molecular Chaperones metabolism, Protein Binding, Protein Transport, RNA, Small Nuclear genetics, RNA, Small Nuclear metabolism, Spliceosomes metabolism, Transcription, Genetic, Ribonucleoproteins, Small Nuclear metabolism, SMN Complex Proteins metabolism
- Abstract
Survival Motor Neuron (SMN) protein localizes to both the nucleus and the cytoplasm. Cytoplasmic SMN is diffusely localized in large oligomeric complexes with core member proteins, called Gemins. Biochemical and cell biological studies have demonstrated that the SMN complex is required for the cytoplasmic assembly and nuclear transport of Sm-class ribonucleoproteins (RNPs). Nuclear SMN accumulates with spliceosomal small nuclear (sn)RNPs in Cajal bodies, sub-domains involved in multiple facets of snRNP maturation. Thus, the SMN complex forms stable associations with both nuclear and cytoplasmic snRNPs, and plays a critical role in their biogenesis. In this review, we focus on potential functions of the nuclear SMN complex, with particular emphasis on its role within the Cajal body.
- Published
- 2017
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