1. [Immunosupressive effect of hypokinetic stress and sensitization of thymus to glucocorticoids].
- Author
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Tseĭlikman VÉ, Filimonova TA, Sibiriak SV, Sinitskiĭ AI, Kozochkin DA, and Strel'nikova LA
- Subjects
- Animals, Apoptosis drug effects, Cell Count, Cell Proliferation drug effects, Cell Separation, Cells, Cultured, Erythrocytes immunology, Hypersensitivity, Delayed immunology, Hypersensitivity, Delayed physiopathology, Hypokinesia physiopathology, Immune Tolerance, Immunity, Humoral drug effects, Immunization methods, Injections, Intraperitoneal, Mitosis drug effects, Rats, Rats, Wistar, Sheep, T-Lymphocytes cytology, Thymus Gland cytology, Glucocorticoids pharmacology, Hypokinesia immunology, Immunity, Cellular drug effects, T-Lymphocytes immunology, Thymus Gland immunology
- Abstract
24-hour hypokinetic stress expressed in decrease of sensitivity of cellular and humoral immu nity to subsequent immunization with sheep erythrocytes was studied. The development of this phenomenon is associated with sensitization of lymphoid tissue to hypoplasia effect of glycocorticoid hormones. In introduction of glycocorticoid stress, the animals revealed a more pronounced depression of proliferative activity of thymocytes compared with non stressed animals.
- Published
- 2011