1. Concise two-step chemical synthesis of molnupiravir
- Author
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Vinícius R. D. Pereira, Marco A. M. Bezerra, Mauro R. B. P. Gomez, Guilherme M. Martins, Adilson D. da Silva, Kleber T. de Oliveira, Rodrigo O. M. A. de Souza, and Giovanni W. Amarante
- Subjects
General Chemical Engineering ,General Chemistry - Abstract
A concise synthesis of molnupiravir in a one-pot two-step approach starting from uridine is described. Formally, herein, two sets of one-pot two-reaction steps introducing simplicity for purifications and using chemically available reagents are presented. In this context, molnupiravir was obtained in up to 68% overall yield and multigram-scale. In addition, HPLC analysis showed the molnupiravir purity above 99%.
- Published
- 2022