Search

Your search keyword '"Ahmed R. Hamed"' showing total 3 results
Start Over Author "Ahmed R. Hamed" Journal rsc advances
3 results on '"Ahmed R. Hamed"'

1. Sarcoehrenbergilides D–F: cytotoxic cembrene diterpenoids from the soft coral Sarcophyton ehrenbergi

Author

Ahmed R. Hamed, Akemi Umeyama, Shinji Ohta, Thomas Efferth, Mohamed-Elamir F. Hegazy, Abdelsamed I. Elshamy, Mahmoud A. A. Ibrahim, Tarik A. Mohamed, and Paul W. Paré

Subjects
Circular dichroism, Chemistry, Stereochemistry, General Chemical Engineering, Coral, Sarcophyton ehrenbergi, 02 engineering and technology, General Chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Cytotoxic T cell, 0210 nano-technology, Cytotoxicity, Human cancer
Abstract

A solvent extract of the soft coral Sarcophyton ehrenbergi afforded cembrene diterpenoids, sarcoehrenbergilid D–F (1–3). Chemical structures were established by modern spectroscopic techniques with absolute stereochemistries determined by circular dichroism (CD) and time-dependent density functional theory electronic CD calculations (TDDFT-ECD). Cytotoxicity activities for 1–3 were evaluated against three human cancer cell lines: lung (A549), colon (Caco-2) and liver (HepG2).

Published
2019
Full Text
View/download PDF

3. Anti-inflammatory sesquiterpenes from the medicinal herb Tanacetum sinaicum

Author

Hisashi Matsuda, Paul W. Paré, Abdessamad Debbab, Tarik A. Mohamed, Ahmed R. Hamed, Mohamed-Elamir F. Hegazy, and Seikou Nakamura

Subjects
Traditional medicine, biology, Chemistry, Stereochemistry, medicine.drug_class, General Chemical Engineering, Ether, General Chemistry, Protein expression, Anti-inflammatory, Nitric oxide, Nitric oxide synthase, chemistry.chemical_compound, biology.protein, medicine, Medicinal herbs, No production, IC50
Abstract

New sesquiterpenes tanacetolide A–C (1–3) were isolated from a Tanacetum sinaicum extract together with known compounds (4–10). The structures were elucidated on the basis of MS and NMR spectroscopic data. All the compounds were evaluated for the inhibition of inducible nitric oxide (NO) production in a mouse peritoneal macrophage system. Iso-seco-tanapartholide-3-O-methyl ether (4) produced potent inhibition of NO production (IC50 = 1.0 μM). At the protein expression level, 4 elicited concentration-dependant down-regulation of inducible nitric oxide synthase.

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results