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Start Over Author "Armanetti, P." Journal rsc advances
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2. Phosphorescent iridium-containing nanomicelles: synthesis, characterization and preliminary applications in nanomedical imaging

Author

Paolo Armanetti, M. Comes Franchini, Paolo Zani, Andrea Baschieri, Erica Locatelli, Letizia Sambri, Luca Menichetti, Elia Matteucci, Ilaria Monaco, Mirko Maturi, Monaco, I., Maturi, M., Matteucci, E., Locatelli, E., Baschieri, A., Zani, P., Armanetti, P., Menichetti, L., Sambri, L., and Comes Franchini, M.

Subjects
Materials science, General Chemical Engineering, Nanoparticle, chemistry.chemical_element, Nanotechnology, 02 engineering and technology, General Chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, Polymeric nanoparticles, Biocompatible material, 01 natural sciences, 0104 chemical sciences, Characterization (materials science), chemistry, Nanomedicine, Iridium, Imaging, Ir-complexes, Nanomedicine, organic ligands, 0210 nano-technology, Phosphorescence
Abstract

Diagnostic nanomedicine constantly requires the development of novel contrast agents with intrinsic imaging capabilities. Phosphorescent Ir(III)-complexes represent good candidates when delivered through polymeric nanoparticles. In this work, we propose a biocompatible nanoparticle made from an intrinsically phosphorescent copolymer, synthesized directly with an imaging tag present on its backbone. Polymeric nanoparticles can be obtained with the exact amount of phosphorescent moieties needed to maximize their output signal. Complete characterization and ex vivo studies confirmed that this nanosystem is suitable as a future diagnostic tool.

Published
2018

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