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Your search keyword '"Korchagina, D."' showing total 15 results
Start Over Author "Korchagina, D." Journal russian chemical bulletin
15 results on '"Korchagina, D."'

7. Synthesis and analgesic activity of alkyl-substituted octahydro-2H-chromenols.

Author

Il'ina, I. V., Korchagina, D. V., Morozova, E. A., Tolstikova, T. G., Volcho, K. P., and Salakhutdinov, N. F.

Subjects
COLUMN chromatography, MONOTERPENOIDS, IN vivo studies, DIASTEREOISOMERS, ALDEHYDES
Abstract

A series of new compounds with hydrogenated 2H-chromene framework was synthesized starting from aliphatic aldehydes and available p-menthane monoterpenoid (−)-isopulegol in the presence of montmorillonite K10. These compounds were formed as a pair of diastereoisomers, which were isolated individually using column chromatography. Some of the compounds obtained were found to exhibit high analgesic activity in in vivo tests. [ABSTRACT FROM AUTHOR]

Published
2022
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9. Synthesis and analgesic activity of octahydro-2H-chromenols, derivatives of aliphatic ketones.

Author

Il'ina, I. V., Korchagina, D. V., Morozova, E. A., Tolstikova, T. G., Volcho, K. P., and Salakhutdinov, N. F.

Subjects
KETONE derivatives, IN vivo studies, KETONES, HETEROCYCLIC compounds, MONOTERPENOIDS
Abstract

A series of compounds with a hydrogenated 2H-chromene skeleton was synthesized by the reaction of ketones and available para-menthane monoterpenoid (—)-isopulegol. A condensation product of (—)-isopulegol with the monoterpene ketone l-menthone was synthesized for the first time. The synthesized heterocycles were tested for analgesic activity and compounds with high analgesic activity in the in vivo tests were identified. [ABSTRACT FROM AUTHOR]

Published
2019
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10. Synthesis and cytotoxic activity of substituted hexahydro-2H-4,6-(epoxymethano)chromen-8(5 H)-ones obtained from (-)-verbenone.

Author

Il'ina, I., Pokrovsky, M., Mikhalchenko, O., Korchagina, D., Volcho, K., Pokrovsky, A., and Salakhutdinov, N.

Subjects
CELL-mediated cytotoxicity, VERBENONE, AROMATIC aldehydes, MONOTERPENOIDS, CELL lines, METHOXY group
Abstract

A number of compounds with a substituted hexahydro-2 H-4,6-(epoxymethano)chromen8(5 H)-one framework was synthesized starting from monoterpenoid (-)-verbenone and aromatic aldehydes containing methoxy and hydroxy groups. Cytotoxic activity of these compounds on human tumor cell lines was studied for the first time. Compounds containing three methoxy groups in each aromatic ring were found to be the most promising for further studies. [ABSTRACT FROM AUTHOR]

Published
2015
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11. First synthesis of p-mentha-1,8-diene triol.

Author

Ardashov, O. V., Khaid, E. V., Mikhal’chenko, O. S., Korchagina, D. V., Volcho, K. P., and Salakhutdinov, N. F.

Subjects
MONOTERPENES, GLYCOLS, EPOXY compounds, VERBENONE, ISOMERIZATION, ACID catalysts, REARRANGEMENTS (Chemistry), MONTMORILLONITE, CHEMICAL synthesis
Abstract

The first synthesis of p-mentha-1,8-diene triol from (−)-verbenone included obtaining pinane epoxy diol and its subsequent acid-catalyzed rearrangement on montmorillonite clay as the key steps. [ABSTRACT FROM AUTHOR]

Published
2013
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12. Study of 9-R-9,10-dimethylphenanthrenonium ions by the method of nuclear magnetic resonance of carbon

Author

Rezvukhin, A. I., Korchagina, D. V., and Shubin, V. G.

Abstract

1.The13C NMR spectra of six 9-R-9,10-dimethylphenanthrenonium ions have been obtained for suppression of the {1H}-13C spin-spin bonding.2.The chemical shifts of the C10 atom (the carbonium center) of these ions are slightly sensitive to change in the substituent R.3.The value of the positive p charge at the carbonium center of the 9,9,10-trimethylphenanthrenonium ion (0.56 charge unit) has been estimated from the13C NMR spectra.4.The equilibrium concentration of ions of the phenonium type, which may participate as intermediate compounds in the degenerate regrouping of 9-X-phenyl-9,10-dimethylphenanthrenonium ions, does not exceed 3%

Published
1976
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13. Automerization of the 9,9,10-triethylphenanthrenonium ion

Author

Korchagina, D. V., Derendyaev, B. G., and Shubin, V. G.

Abstract

Employing the NMR method it was shown that the 9,9,10-triethylphenanthrenonium ion undergoes rapid automerization as the result of intramolecular transitions of the ethyl group between the C9 and C10 atoms. The kinetics of the automerization was studied.

Published
1971
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