1. Copper complexes: cytotoxicity and transport possibilities
- Author
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A. P. Orlov, Tatiana P. Trofimova, A. S. Borodkov, Alexander A. Yaroslavov, Alexey N. Proshin, N. S. Zolotova, V. V. Spiridonov, I. A. Ivanov, and Marina A. Orlova
- Subjects
Copper complex ,medicine.diagnostic_test ,010405 organic chemistry ,chemistry.chemical_element ,General Chemistry ,010402 general chemistry ,Mass spectrometry ,01 natural sciences ,Copper ,Jurkat cells ,0104 chemical sciences ,Flow cytometry ,chemistry.chemical_compound ,chemistry ,Elemental analysis ,medicine ,Benzamide ,Cytotoxicity ,Nuclear chemistry - Abstract
A copper complex with N-(5,6-dihydro-4H-1,3-thiazin-2-yl)benzamide was synthesized for the first time and characterized by 1H NMR spectroscopy, LETDY mass spectrometry, and elemental analysis. A comparative study of the obtained complex and copper 2-aminopyrimidine complex was performed by flow cytometry on normal lymphocytes and Jurkat cells. Complexes with radionuclides 64,67Cu (with and wihout a carrier) were prepared, and distribution of the labeled complexes in the organs of mice was considered. Packing in carboxymethylcellulose-based microgels was proposed as a transport form for the complexes. The results show a promise of the obtained materials as potential radiopharmaceutical agents.
- Published
- 2019
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