1. Chan–Lam N-Arylation of Adamantane-Containing Amines.
- Author
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Kuliukhina, D. S., Malysheva, A. S., Averin, A. D., Savelyev, E. N., Orlinson, B. S., Novakov, I. A., and Beletskaya, I. P.
- Subjects
ADAMANTANE derivatives ,DIAMINES ,AMINES ,AMINO group ,COPPER ,STERIC hindrance ,AMINE derivatives - Abstract
The Chan–Lam reaction conditions were optimized for the synthesis of N-aryl derivatives of adamantane-containing amines. A number of adamantane-containing amines and diamines with different steric hindrances at the primary amino groups were reacted with p-tolylboronic acid under the optimized conditions [0.1 M solution of amine in MeCN, p-tolylboronic acid (2 equiv), DBU (2 equiv), copper(II) acetate (20 mol %), 25°C, 24 h]. The reactivity of the amines was found to strongly depend on their structure, and the maximum yield of the target products reached 74% from the monoamines and 66% from the diamines. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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