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Due to Brazil's huge extension and to different social, economic, demographic and cultural conditions, several regions in Brazil feature infectious and parasite diseases (IPDs). Current analysis assesses whether IPDs in the municipalities of the Health Regional Superintendence of Alfenas MG Brazil are related to specific risk factors. Current populated-based transversal, descriptive and quantitative study employs secondary data from the 2010 demographic census, by Pearson's co-relationship. All health and educational indicators significantly co-relate themselves with mortality due to IPDs, The water supply system and the number of sewerage and rainwater per network unit were the variables of basic sanitation indexes with the highest co-relation scores. In the case of economic indicators, the monthly income of half the minimum wage or without any monthly earnings significantly affected IPD-based mortality. Only the number of births weighing less than 2500g had any relationship to IPDs. Results showed environmental and sanitation conditions, coupled to the social and economic factors of residents in homes with such characteristics, plus the dissemination of basic measures for personal, home and community hygiene impact population's health. The latter influences morbidity and mortality by diseases of different etiologies, including IPDs. Knowledge on the prevalence and main associated variables may be a help in evaluating the problem and the planning and implementation of activities for the health and prevention of health-disease relationships. [ABSTRACT FROM AUTHOR]