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Start Over Author "Jonsson" Journal scandinavian journal of immunology
459 results on '"Jonsson"'

1. No signs of mast cell involvement in long‐COVID: A case–control study.

Author

Lenning, Ole Bernt, Jonsson, Grete, Grimstad, Tore, Janssen, Emiel A. M., Braut, Geir Sverre, Berven, Frode, and Omdal, Roald

Subjects
*MAST cells, *PROTEOLYTIC enzymes, *CONTROL groups, *IMMUNOASSAY, *DISEASE complications
Abstract

Long‐COVID caused by SARS‐CoV‐2 infection has significant and increasing effects on human health worldwide. Although a unifying molecular or biological explanation is lacking, several pathophysiological mechanisms have been proposed. Involvement of mast cells—evolutionary old "multipurpose" innate immune cells—was reported recently in studies of acute infection and post‐acute‐COVID‐19 syndrome. Mast cell activity has been suggested in long‐COVID. In this case–control study, we compared data from 24 individuals with long‐COVID (according to the NICE criteria) and 24 age‐ and sex‐matched healthy individuals with a history of SARS‐CoV‐2 infection without developing sequelae. Serum levels of the proteases beta‐tryptase (TPSB2) and carboxypeptidase (CPA3), which are mast cell specific, were measured using immunoassays. The values were compared between the two groups and correlated to measures of physical exertional intolerance. TPSB2 and CPA3 levels were median (range) 26.9 (2.0–1000) and 5.8 (1.5–14.0) ng/mL, respectively, in the long‐COVID group. The corresponding values in the control group were 10.9 (2.0–1000) (p = 0.93) and 5.3 (3.5–12.9) ng/mL (p = 0.82). No significant correlations between TPSB2 or CPA3 levels and scores on the ten physical subscales of SF‐36, 3.1–3.10 were revealed. We found no significant differences in the levels of mast cell activation markers TPSB2 and CPA3 between the long‐COVID and control groups and no correlations with proxy markers of exercise intolerance. Mast cell activation does not appear to be part of long‐term pathogenesis of long‐COVID, at least in the majority of patients. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Association of Genes in the NF-κB Pathway with Antibody-Positive Primary Sjögrenʼs Syndrome

Author

Nordmark, Gunnel, Wang, Chuan, Vasaitis, Lilian, Eriksson, Per, Theander, Elke, Kvarnström, Marika, Forsblad-dʼElia, Helena, Jazebi, Helmi, Sjöwall, Christopher, Reksten, Tove Ragna, Brun, Johan G., Jonsson, Malin V., Johnsen, Svein J., Wahren-Herlenius, Marie, Omdal, Roald, Jonsson, Roland, Bowman, Simon, Ng, Wan-Fai, Eloranta, Maija-Leena, and Syvänen, Ann-Christine

Published
2013
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25. Covid‐19, SSI 50 years and Nobel: Three immunological reasons to remember 2020

Author

Roland Jonsson, Hans-Gustaf Ljunggren, and Petter Höglund

Subjects
2019-20 coronavirus outbreak, Editorial, Coronavirus disease 2019 (COVID-19), business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Immunology, MEDLINE, Medicine, General Medicine, business, Virology
Published
2020

29. Low Protein A20 in Minor Salivary Glands is Associated with Lymphoma in Primary Sjögren's Syndrome

Author

Roland Jonsson, Einar Gudlaugsson, Emiel A. M. Janssen, Ellen Berget, Roald Omdal, Lars Helgeland, Svein Joar Auglænd Johnsen, Malin V. Jonsson, and Ivar Skaland

Subjects
Adult, Male, 0301 basic medicine, Pathology, medicine.medical_specialty, Low protein, Immunology, Salivary Glands, 03 medical and health sciences, 0302 clinical medicine, immune system diseases, hemic and lymphatic diseases, Humans, Medicine, Nuclear protein, Tumor Necrosis Factor alpha-Induced Protein 3, B cell, Aged, Aged, 80 and over, 030203 arthritis & rheumatology, B-Lymphocytes, business.industry, Intracellular Signaling Peptides and Proteins, NF-kappa B, Nuclear Proteins, Germinal center, MALT lymphoma, Lymphoma, B-Cell, Marginal Zone, General Medicine, Middle Aged, Germinal Center, medicine.disease, Immunohistochemistry, Lymphoma, DNA-Binding Proteins, Sjogren's Syndrome, 030104 developmental biology, Lymphatic system, medicine.anatomical_structure, Female, business
Abstract

Patients with primary Sjogren's syndrome (pSS) have an increased risk of developing lymphomas, particularly the subtype mucosa-associated lymphoid tissue (MALT) lymphoma. Chronic antigen stimulation and increased activation of nuclear factor-κB (NF-κB) are important factors for the pathogenesis of MALT lymphomas. Protein A20 is an inhibitor of NF-κB. A recent study of pSS-associated MALT lymphomas identified potential functional abnormalities in the TNFAIP3 gene, which encodes protein A20. The present study aimed to assess protein A20 by immunohistochemistry (IHC) in minor salivary glands (MSGs) and lymphoma tissue sections of patients with pSS and investigate a potential association with lymphoma development. Protein A20 staining in lymphocytes was scored in four categories (0 = negative, 1 = weak, 2 = moderate and 3 = strong). For statistical purposes, these scores were simplified into negative (scores 0-1) and positive (scores 2-3). We investigated associations between protein A20-staining, focus scores, germinal centre (GC)-like structures and monoclonal B-cell infiltration in MSGs. MSG protein A20 staining was weaker in pSS patients with lymphomas than in those without lymphomas (P = 0.01). Weak protein A20 staining was also highly associated with a lack of GC formation (P

Published
2016

43. Expression of Toll-Like Receptors in Peripheral Blood Mononuclear Cells of Patients with Primary Sjögren's Syndrome

Author

Marie Karlsen, Roland Jonsson, Silke Appel, Torbjørn Hansen, Daniel Hammenfors, and Kjerstin Jakobsen

Subjects
Adult, Male, musculoskeletal diseases, 0301 basic medicine, Immunology, Autoantigens, Peripheral blood mononuclear cell, 03 medical and health sciences, 0302 clinical medicine, stomatognathic system, Humans, Medicine, RNA, Messenger, Receptor, Aged, Autoantibodies, 030203 arthritis & rheumatology, Autoimmune disease, business.industry, Toll-Like Receptors, Pattern recognition receptor, Autoantibody, TLR9, General Medicine, TLR7, Middle Aged, TLR8, medicine.disease, eye diseases, stomatognathic diseases, Sjogren's Syndrome, 030104 developmental biology, Leukocytes, Mononuclear, Female, business
Abstract

Toll-like receptors (TLRs) are pattern recognition receptors important for the detection of pathogen-associated molecular patterns. They are localized on cellular membranes, on either the cell surface or the endosomes. Primary Sjögren's syndrome (pSS) is a systemic rheumatic autoimmune disease characterized by lymphocytic infiltrations in exocrine glands resulting in dryness in eyes and mouth. In a majority of patients, autoantibodies against Ro/SSA and/or La/SSB are present. Here we analysed mRNA levels of TLR1-10 and protein expression levels of most of them in human peripheral blood mononuclear cells from 20 patients with pSS and 20 healthy controls. Patients with pSS showed significantly higher mRNA levels of TLR8 than controls, while transcript levels of TLR9 were significantly lower. At the protein level, patients with pSS expressed significantly less TLR5 and significantly more TLR7 compared with healthy controls. TLR7 and 8 are encoded by genes localized on the X chromosome, which is especially interesting regarding the gender imbalance of pSS. The differential expression of various TLR in PBMC of patients with pSS might contribute to an altered recognition of nucleic acids, eventually resulting in the development of autoimmune disease.

Published
2017

48. Göran Möller 1936–2008

Author

Jonsson, Roland, Ljunggren, Hans-Gustaf, Natvig, Jacob B., and Örn, Anders

Published
2008

49. CD21

Author

Katrin, Thorarinsdottir, Alessandro, Camponeschi, Charlotte, Jonsson, Karin, Granhagen Önnheim, Jenny, Nilsson, Kristina, Forslind, Marcella, Visentini, Lennart, Jacobsson, Inga-Lill, Mårtensson, and Inger, Gjertsson

Subjects
Adult, Male, Receptors, CXCR3, RANK Ligand, B-Lymphocyte Subsets, Immunoglobulin D, Middle Aged, Chemokine CXCL9, Tumor Necrosis Factor Receptor Superfamily, Member 7, Arthritis, Rheumatoid, Chemokine CXCL10, Synovial Fluid, Humans, Female, Joints, Receptors, Complement 3d
Abstract

Depletion of B cells is beneficial in rheumatoid arthritis (RA) patients with autoantibodies to citrullinated proteins (ACPA) and/or the Fc portion of immunoglobulins (rheumatoid factor [RF]), suggesting a role for B cells in disease pathogenesis. To date, however, the identity of specifically pathogenic B cell subsets has not been discovered. One candidate population is identified by the low expression or absence of complement receptor 2 (CD21

Published
2019

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