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Participants with a positive faecal immunochemical test (FIT) in screening programs for colorectal cancer (CRC) have a high risk for colorectal cancer and advanced adenomas. They are therefore recommended follow-up by colonoscopy. However, more than ten percent of positively screened persons do not adhere to this advice. To investigate FIT-positive individuals’ motives for non-adherence to colonoscopy advice in the Dutch CRC screening program. Non-adherent FIT-positive participants of the Dutch CRC screening program. We conducted semi structured in-depth interviews with 17 persons who did not undergo colonoscopy within 6 months after a positive FIT. Interviews were undertaken face-to-face and data were analysed thematically with open coding and constant comparison. All participants had multifactorial motives for non-adherence. A preference for more personalised care was described with the following themes: aversion against the design of the screening program, expectations of personalised care, emotions associated with experiences of impersonal care and a desire for counselling where options other than colonoscopy could be discussed. Furthermore, intrinsic motives were: having a perception of low risk for CRC (described by all participants), aversion and fear of colonoscopy, distrust, reluctant attitude to the treatment of cancer and cancer fatalism. Extrinsic motives were: having other health issues or priorities, practical barriers, advice from a general practitioner (GP) and financial reasons. Personalised screening counselling might have helped to improve the interviewees’ experiences with the screening program as well as their knowledge on CRC and CRC screening. Future studies should explore whether personalised screening counselling also has potential to increase adherence rates.Key pointsParticipants with a positive FIT in two-step colorectal cancer (CRC) screening programs are at high risk for colorectal cancer and advanced adenomas. Non-adherence after an unfavourable screening result happens in all CRC programs worldwide with the consequence that many of the participants do not undergo colonoscopy for the definitive assessment of the presence of colorectal cancer. Little qualitative research has been done to study the reasons why individuals participate in the first step of the screening but not in the second step. We found a preference for more personalised care, which was not reported in previous literature on this subject. Furthermore, intrinsic factors, such as a low risk perception and distrust, and extrinsic factors, such as the presence of other health issues and GP advice, may also play a role in non-adherence. A person-centred approach in the form of a screening counselling session may be beneficial for this group of CRC screening participants. Participants with a positive FIT in two-step colorectal cancer (CRC) screening programs are at high risk for colorectal cancer and advanced adenomas. Non-adherence after an unfavourable screening result happens in all CRC programs worldwide with the consequence that many of the participants do not undergo colonoscopy for the definitive assessment of the presence of colorectal cancer. Little qualitative research has been done to study the reasons why individuals participate in the first step of the screening but not in the second step. We found a preference for more personalised care, which was not reported in previous literature on this subject. Furthermore, intrinsic factors, such as a low risk perception and distrust, and extrinsic factors, such as the presence of other health issues and GP advice, may also play a role in non-adherence. A person-centred approach in the form of a screening counselling session may be beneficial for this group of CRC screening participants.

Objective - To identify medical and psychosocial indicators of childhood adversity in somatising patients in primary care. Design - Retrospective questionnaires and interviews. Setting - Primary health care in The Netherlands. Subjects - Three-hundred-and-seventy-four somatising frequent attenders in 27 general practices between 20 and 45 years of age. Main outcome measures - Major problems in childhood. Results - The questionnaire on childhood problems reflected acceptable validity against a structured interview in 77 patients (correlation 0.69); however, the item ''abuse'' was underreported in the questionnaire. Four out of five patients reported one or more major childhood problems. Childhood adversity was indicated independently by chronic difficulties in present relations and by genital-sexual symptoms of patients. Conclusion - When GPs want to take a more active approach towards somatisers they may show interest in the childhood and life story of patients, especially when patients are known with chr...

Objectives - To describe the risk-factor profile and cardiovascular comorbidity of asymptomatic peripheral arterial occlusive disease (PAOD). Design - A cross-sectional survey. Asymptomatic PAOD wa...

In the Netherlands, as in other countries, the prevalence of long-term use of benzodiazepines is high. There was a high correlation between long-term use of benzodiazepines on the one hand and age and psychic condition on the other. The use was much higher in women than in men. Health problems were mentioned most (patient's view) as causing the use. Objective &#114 - &#114 To know more about the characteristics of long-term users of hypnotic and tranquillising drugs in a primary health care area in The Netherlands. Design &#114 - &#114 A questionnaire was applied to users of benzodiazepines and the computerised medical records were analysed. Setting &#114 - &#114 Nine general practices affiliated to the Registration Network Family Practices (RNH) of the University of Maastricht (UM). Subjects &#114 - &#114 A sample of 506 users, aged &#85 30 years, was divided into four categories: short-term (

To study the occurrence and distribution of arrhythmias in patients with symptoms possibly caused by arrhythmias, in order to support the diagnostic process in general practice.From 1989-1991 all patients who consulted their general practitioner with symptoms or signs possibly indicating an arrhythmia had a transtelephonic electrocardiogram, which was sent to the Department of Cardiology for interpretation.20 Dutch general practices, serving a population of nearly 50,000 inhabitants.A total of 868 patients were included in the study.An arrhythmia was documented by ECG in 32% of the patients. Of these, 31% clinically more relevant arrhythmias needed medical attention. An incidence of 2.6 arrhythmias per 1000 listed patients was calculated. There was a highly positive correlation between the occurrence of arrhythmias and age. Relatively more arrhythmias were seen in men, in patients with occasional findings, and when there were symptoms that possibly indicated haemodynamic imbalance.Clinically relevant arrhythmias can be detected in general practice with 12-lead ECG recording in a significant proportion of patients with symptoms and physical findings suggesting an arrhythmia. The distribution of arrhythmias described in this study can help general practitioners in their diagnostic management.

We investigated the ability of the leucocyte count to discriminate between "inflammatory diseases and malignancies" on the one hand and other, often harmless and self-limiting diseases on the other, and compared this ability with that of the erythrocyte sedimentation rate (ESR) in general practice. In cooperation with nine general practitioners (GP) we prospectively followed 151 patients who were seen by their GP because of a new complaint for which the GP wanted to know their ESR. ESR and one leucocyte count measurement (Technicon H6000) were performed at the local hospital laboratory. The patients were seen again after three months, to determine the follow-up diagnoses. By comparing the test results with the follow-up diagnoses, ESR was found to have a better discriminating ability than the leucocyte count test (ESR: sensitivity = 53%, specificity = 84%, positive predictive value = 29%, negative predictive value = 93%, Odds Ratio = 5.73). Using Receiver Operating Characteristic analysis, this conclusion could be shown to be independent of the chosen reference values. We conclude that the determination of the leucocyte count is not a clinically interesting alternative to ESR.

One of the non-invasive techniques used in the diagnosis of patients with peripheral arterial occlusive disease is the measurement of the Ankle-Arm Systolic Pressure Ratio ("AA-Ratio"). The magnitude of different sources of measurement variation, relevant to clinical practice as well as multi-observer studies, was estimated from a random effects analysis of variance model. Thirty-five GPs and 24 practice assistants performed 503 AA-Ratio measurements on nine patients over a period of nine weeks, using pocket Doppler devices. When the AA-Ratio is used for diagnostic purposes, a 95% prediction interval consisting of the measured value +/- 15-20% AA-Ratio has to be taken into account. Furthermore, when the AA-Ratio is used in the follow-up of a patient with vascular disease, the difference between two subsequent measurements has to be at least 15.6-19.0% AA-Ratio to have an 80% certainty that this difference is not due to (intra-observer) measurement error.