1. A novel ECG-biomarker for cardiac arrest during hypothermia
- Author
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Torkjel Tveita, Rachel C. Myles, Erik Sveberg Dietrichs, and Godfrey L. Smith
- Subjects
Male ,medicine.medical_specialty ,Accidental hypothermia ,Hypothermia ,Critical Care and Intensive Care Medicine ,QT interval ,Electrocardiography ,03 medical and health sciences ,QRS complex ,Ventricular arrhythmias ,0302 clinical medicine ,Hypothermia, Induced ,Internal medicine ,medicine ,Animals ,Humans ,Therapeutic hypothermia ,VDP::Medisinske Fag: 700 ,cardiovascular diseases ,030212 general & internal medicine ,New zealand white ,Rewarming ,business.industry ,lcsh:Medical emergencies. Critical care. Intensive care. First aid ,030208 emergency & critical care medicine ,lcsh:RC86-88.9 ,Cardiac arrest ,medicine.disease ,Heart Arrest ,Electrophysiology ,VDP::Medical disciplines: 700 ,Disease Models, Animal ,Ventricular Fibrillation ,Ventricular fibrillation ,Commentary ,cardiovascular system ,Emergency Medicine ,Cardiology ,Biomarker (medicine) ,Female ,Rabbits ,medicine.symptom ,business ,Biomarkers ,circulatory and respiratory physiology - Abstract
Background Treatment of arrhythmias evoked by accidental or therapeutic hypothermia and rewarming remains challenging. We aim to find an ECG-biomarker that can predict ventricular arrhythmias at temperatures occurring in therapeutic and accidental hypothermia. Main body Evaluation of ECG-data from accidental and therapeutic hypothermia patients and experimental data on ECG and ventricular fibrillation (VF) threshold in hypothermic New Zealand White Rabbits. VF threshold was measured in rabbit hearts cooled to moderate (31 °C) and severe (17 °C) hypothermia. QRS-interval divided by corrected QT-interval (QTc) was calculated at same temperatures. Clinical QRS/QTc data were obtained after a systematic literature review. Rabbit QRS/QTc values correlated with risk for VF (correlation coefficient: 0.97). Human QRS/QTc values from hypothermic patients, showed similar correlation with risk for ventricular fibrillation in the experimental data (correlation coefficient: 1.00). Conclusions These calculations indicate that QRS/QTc has potential as novel biomarker for predicting risk of hypothermia-induced cardiac arrest. Our findings apply both to victims of accidental hypothermia and to patients undergoing therapeutic hypothermia during surgery or after e.g. cardiac arrest.
- Published
- 2020
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